DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and Ehbp1

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster

Alignment Length:	810	Identity:	184/810 - (22%)
Similarity:	297/810 - (36%)	Gaps:	222/810 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 SIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSF 176
            |||:.....|:|..:|..:..|:|:         |.|..:.||.||:..|..|.||.|.|...|:
  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487

  Fly   177 KDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAI 241
            ::|:||||:||...|:|||.:|||..:.:.|....||.||. |.|||:::|.|:.....||:.|:
  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551

  Fly   242 MTYVSCYYHAFQGAQ----QVGNVTHVPEPTRQYTYVPNNYNAET-AANRI----CKVLKVNQEN 297
            |||:......|.|.|    |:|:...      :.:||..:|.::. :.|||    .|.|.::|.:
  Fly   552 MTYLHQLRAHFTGKQLKIEQIGSTAD------ESSYVIGDYKSDNLSQNRINFSHPKSLLLHQNS 610

  Fly   298 ERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKK-LEEYRTYRRKHKPPRVEQKAKLET 361
              ..||                  :|.......|:...|| ::....|..|:...:|....|.:.
  Fly   611 --FDEE------------------INGSNKSEQLSPTSKKDVKNLILYNSKNILDKVLSPTKDKN 655

  Fly   362 NFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEK------------AFEEWLLAETMRL 414
            :.|..|.    :|:...|..:.....|.|.. ||.:...|            |.||   .:...|
  Fly   656 SINASQH----ANQSPMLSCQTTPPQDESLD-KGSQPGGKENSSITTIDPQAASEE---RQQRLL 712

  Fly   415 ERLEHLAQKFKHKADAH-EDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVE- 477
            |:...|..:.:.|:... |..||.|.|               :.:...|...|...|.|..::|
  Fly   713 EQARRLILETRVKSGGSIESPTRPKLE---------------RTISPIHNGAEEFYAEHAKKLEL 762

  Fly   478 -QIAAIAQELN---TLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKID--ILH 536
             :..:.:..|:   .|:     |.||..:|:..:.::.|.......:.|:..||..|.||  ..:
  Fly   763 KEPGSPSHRLSDPKVLQ-----SFNAIVERVSPKHEKRGDKLSYIDSELEALEREQEAIDQKASN 822

  Fly   537 LEFAKRAA----PFNNWLDGTREDLVDMFIVHTMEEIQG-------LIQAHDQ--FKATLG---- 584
            ||...||.    |.||...|.|..  :.|:......|.|       |:.:.|:  |....|
  Fly   823 LEAKLRAVMGGNPSNNRRGGARNS--NPFLRLIRNSIGGGDVIRIKLLDSDDESLFGGGAGSGGG 885

  Fly   585 ---------EADKEFNLIVNLVREVES------------IVKQHQ----IPGGLEN-------PY 617
                     :.|...:.:.|...|:.:            :.|.||    .|..|..       ||
  Fly   886 RSGACSEDDDRDTSSDSVCNSGDELHTRLRPRPRSHSCFVNKNHQSTINTPAHLRPHHVHHVVPY 950

  Fly   618 TTL------------TANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKAN----- 665
            |.:            ::.|.....||..:::.......|..||:||:....|||..|:.:
  Fly   951 THMLDSSPSALSSQQSSCDNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRERRSHLCHT 1015

  Fly   666 ------------IVGPW----------IERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKP 708
                        ::..|          :.|||                ||:.|::.:.....|..
  Fly  1016 PNHCETEETEEQLLSQWFTLVNKKNALLRRQM----------------QLNILEQEKDLERKYTM 1064

  Fly   709 NIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRN---INEVENQILTRDSKGISQ 770
            ..:|| :..|:|::.     |.|....|..|:..|:|:|.:::.   :..:.||       .|:.
  Fly  1065 LNQEL-RAAQSVEDW-----RKTEVQREKERLLLEELMTIVDKRDQLVQHLHNQ-------EIAI 1116

  Fly   771 EQLNEFRSSFNHFDKNRTGRLSPEEFKSCL 800
            |...|......|.|      :|.|:.|..|
  Fly  1117 EDDQEIARKLEHVD------ISAEKDKCVL 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	7/22 (32%)
		CH_ACTN_rpt2	139..252	CDD:409065	44/112 (39%)
		SPEC	302..525	CDD:238103	44/241 (18%)
		SPEC	420..647	CDD:238103	56/295 (19%)
		SPEC	538..760	CDD:238103	58/312 (19%)
		EFh	775..842	CDD:238008	7/26 (27%)
		EFhand_Ca_insen	847..913	CDD:400872
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	42/102 (41%)
		DUF3585	<1027..1122	CDD:288945	23/123 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0035
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810