DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and Dyb

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001097287.1	Gene:	Dyb / 36362	FlyBaseID:	FBgn0033739	Length:	816	Species:	Drosophila melanogaster

Alignment Length:	815	Identity:	152/815 - (18%)
Similarity:	252/815 - (30%)	Gaps:	306/815 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EEWEREGL--LDPAWEKQ--QKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETL 80
            |.:...||  |:|..|..  :.:|..:....:|.|.......:..|.:.||.|..||...:.:
  Fly    51 EAFRENGLNTLEPQSEVSVARLETLVSSLYHNLNKRLPTAQQVPVDSKAGLLLNWLLAAYTSD-- 113

  Fly    81 PKPDRGKMRFHKI---------ANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTI--I 134
               :.||:|...|         ..:...|.:|.|:    :|.||.::|          .|.:  .
  Fly   114 ---NSGKIRVFSIKVALATMCSGKLVDKLRYIFSQ----ISDGAGQLV----------AWKLGEF 161

  Fly   135 LR--FAIQDISVEEMT--AKEGLLLWCQRKTAPYKN-VNVQNF--HLSFKDG---LAFCALIHR- 188
            ||  .|:.....|..|  .||||    :.:..|.:| |.|.:|  .|..:.|   |.:..|:||
  Fly   162 LREVLALPAAVYESPTFHYKEGL----EEEIFPAENKVTVNDFMATLMSEPGPSCLVWLPLVHRL 222

  Fly   189 ---------------HRPDLIDY---------------------AKLSKDNPLE----------- 206
                           |:.:...:                     ..|:..|..|
  Fly   223 ATVETIVHPTVCSVCHKENFTGFRYRCQRCHAYQLCQECFWHGKTSLNHQNDHEVKEYSSYKSPS 287

  Fly   207 -----NLNTAFD-VAEKYLDI-PRMLD-PDDLIN-------TPKPDERAIMTYVSCYYHAFQGAQ 256
                 :|..:|. |.||.:.: ||..| |:..:|       :|.|.           ::.|....
  Fly   288 KQIGHSLRKSFRCVPEKTVQVLPRFPDQPEKTLNLSHIVPPSPLPS-----------HNGFSDPS 341

  Fly   257 QVGNVTHVPEPTRQYTYVPNNY-----------------------NAETAANRICKVLKVNQENE 298
            .:.:..|.|.|.     :|..:                       .|.|..:|:. ....|.|..
  Fly   342 GLVHGHHGPHPG-----LPGQHGLFDRSSTLDSRATGRSLDSASGTAGTTMSRVA-AASANDEEH 400

  Fly   299 RLMEEY-ERLASDLLEWIRRTMPWL----------NSRQADNSLAGVQKK----LEEYRTYRRKH 348
            ||:..| .|||.:     .|....|          |||.....:|.::.|    :.|....||:.
  Fly   401 RLIARYAARLAQE-----NRAPSNLPDNATPIGTDNSRAQRELIAQLESKNKEIMREIARLRRQQ 460

  Fly   349 KPPRV---------------EQKAKLETNFNTLQTKLR------------LSNR--------PAY 378
            :..::               ::|.:||.:...||...|            |.|:        |..
  Fly   461 ETEQMAPENPALINELRALRQRKGELEGHLGALQDSRRQLMEQLEGLMRMLKNQQTASPRSTPNS 525

  Fly   379 LPTEGKT-----------VSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHE 432
            .|..||:           .|.:|      .|..:..::..:|..:|..: :.|.|:.:.:|..|.
  Fly   526 SPRSGKSPPMPGGAGILGTSPMS------ALHAQQMQQHPMAGGVRASQ-QQLLQQQQQQAHGHG 583

  Fly   433 DWTRGKEEMLQ--SQDFRQC-------------------------KLN-------ELKALKKKHE 463
            .:::.:.|.|.  |.|.|..                         .||       .|....:.:|
  Fly   584 PFSQSQLEQLNQISSDMRSAFAANGSATPPPMRTTTATANVSAIPSLNPISNQNPNLNPDAELNE 648

  Fly   464 AFE----------SDLAAHQDRVEQI-----AAIAQE--LNTLEYHDCVSVNARCQRICDQWD-R 510
            |.:          |||.|.:.|.:|:     ::|.|.  :..||:.......:.....|:..| .
  Fly   649 AADHLTSAISHMVSDLNAGRGRAQQLGPQPASSIPQARFIMPLEFRHIEGGESEDSSQCECNDCE 713

  Fly   511 LGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQA 575
            .|...:..||..|             ||....||||.|              .:::....| :..
  Fly   714 CGEYEEVFRTDED-------------LECEGAAAPFGN--------------AYSLFPTSG-VHE 750

  Fly   576 HDQFKATLGEADK--EFNLIVNLVREVESIVKQHQ 608
            .|.|..|.|:.::  :.|.|:......|..:...|
  Fly   751 EDHFDYTFGQGEELSQVNRILGYRNHPELFIDDEQ 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	22/116 (19%)
		CH_ACTN_rpt2	139..252	CDD:409065	33/183 (18%)
		SPEC	302..525	CDD:238103	61/335 (18%)
		SPEC	420..647	CDD:238103	46/243 (19%)
		SPEC	538..760	CDD:238103	15/73 (21%)
		EFh	775..842	CDD:238008
		EFhand_Ca_insen	847..913	CDD:400872
Dyb	NP_001097287.1	EF-hand_2	7..131	CDD:286194	19/84 (23%)
		EF-hand_3	135..223	CDD:286195	28/105 (27%)
		ZZ_dystrophin	232..280	CDD:239074	4/47 (9%)
		Ribosomal_L29	436..482	CDD:279204	5/45 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439893
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930