DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and Sptbn4

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_008757363.1	Gene:	Sptbn4 / 308458	RGDID:	1304682	Length:	2609	Species:	Rattus norvegicus

Alignment Length:	783	Identity:	267/783 - (34%)
Similarity:	388/783 - (49%)	Gaps:	128/783 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WERE------------------GLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKL 68
            |:||                  .|.|.. |..||||||.|.||||.:.|..|.::..|.|:|..|
  Rat    81 WDREPPAAANAAASLFECSRIKALADER-EAVQKKTFTKWVNSHLARVGCHIGDLYADLRDGFVL 144

  Fly    69 MLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTI 133
            ..||||:|||.||:|.||:||.|.:.||:|||.|:..:.|||.::|:.:|||||.::|||::|||
  Rat   145 TRLLEVLSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTI 209

  Fly   134 ILRFAIQDISV------EEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPD 192
            ||||.||.|.:      |..:||:.||||||.|||.|..||:|||..|::|||||.|||||||||
  Rat   210 ILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPD 274

  Fly   193 LIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQ 257
            |:|.:||:|.|...||..||..||::|.:.|:|||:| :|...|||::|:|||..:||.|...:.
  Rat   275 LVDLSKLTKSNANYNLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKA 338

  Fly   258 VGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWL 322
            :.                      ....||.|||....|.::::|.||.||::||.||.||:..:
  Rat   339 LA----------------------VEGKRIGKVLDQVLEVDKIIERYEELAAELLAWIHRTVDLI 381

  Fly   323 NSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVS 387
            ::::..|||:|||::|:.:..|....||.:.::|..||....::|:|||..||..::|.||..:.
  Rat   382 SNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRAHNRRLFVPREGCGIW 446

  Fly   388 DISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKL 452
            ||..:|..||.||...|..|.||.:|.|:||.|||:|.||....|.|. .:.:.|.|||....:|
  Rat   447 DIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWL-NENQRLVSQDNFGYEL 510

  Fly   453 NELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQR 517
            ..::|..|||||.|:|:||:::||:.:|.:||.|....|:|...|.|:...:..||..|..|...
  Rat   511 PAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDARRVAAQRDSVLRQWALLTGLVGA 575

  Fly   518 RRTALDEAERILEKI--DILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHD--- 577
            |||.| |....|:|:  :::::.         :|::..:..|:.......:.|...|:|.|.
  Rat   576 RRTRL-EQNLALQKVFQEMVYMV---------DWMEEMQTQLLSRECGQHLVEADDLLQKHGLLE 630

  Fly   578 ------------------QFKATLGEADKEFNLIVNLVREVESIVKQHQIPGG-----LE---NP 616
                              :|....|....:..:|.|.|..|...:.:.|....     ||   :.
  Rat   631 GDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLSELQEQAARRRAELEASRSL 695

  Fly   617 YTTLTANDMTRKW---------------------------SDVRQLVPQRDQTLANEL--RKQQN 652
            :..|...:....|                           |...:|:.|. :.|..||  |:...
  Rat   696 WALLQELEEAESWARDKERLLEATSGSGGAAGTAGGAHDLSSTARLLAQH-KILQGELGGRRALL 759

  Fly   653 NEMLRR--QFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEK 715
            .:.|||  :.|.....|||..|....|      ||.........|.:..|:|....:..::|...
  Rat   760 QQALRRGEELAAAGGSVGPGAEPLHLA------GLAERAASARRRWQRLEEAAARRERRLQEARA 818

  Fly   716 IHQ 718
            :||
  Rat   819 LHQ 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	54/103 (52%)
		CH_ACTN_rpt2	139..252	CDD:409065	64/118 (54%)
		SPEC	302..525	CDD:238103	89/222 (40%)
		SPEC	420..647	CDD:238103	65/284 (23%)
		SPEC	538..760	CDD:238103	41/241 (17%)
		EFh	775..842	CDD:238008
		EFhand_Ca_insen	847..913	CDD:400872
Sptbn4	XP_008757363.1	CH	111..214	CDD:237981	56/102 (55%)
		CH	230..333	CDD:237981	60/103 (58%)
		SPEC	361..584	CDD:238103	90/224 (40%)
		SPEC	479..693	CDD:238103	59/224 (26%)
		SPEC	819..1031	CDD:238103	2/3 (67%)
		SPEC	1135..1239	CDD:197544
		SPEC	1245..1453	CDD:238103
		SPEC	1351..1558	CDD:238103
		SPEC	1560..1771	CDD:238103
		SPEC	1666..1878	CDD:238103
		Spectrin	1878..1977	CDD:278843
		SPEC	1987..>2154	CDD:238103
		PH	2464..2566	CDD:278594
		PH_beta_spectrin	2466..2570	CDD:269975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920