DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and Ehbp1

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_006251627.1	Gene:	Ehbp1 / 305556	RGDID:	1310604	Length:	1205	Species:	Rattus norvegicus

Alignment Length:	851	Identity:	182/851 - (21%)
Similarity:	307/851 - (36%)	Gaps:	223/851 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 EEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLN 209
            ::..|.:.||.||:..|..|:.|.:.||..|:::||:|||::|..|||||||..|:..:..||..
  Rat   421 QKPNASQSLLAWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNK 485

  Fly   210 TAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYV 274
            .|:| ....:.|.|:|:|.|::....||:..:|||:......|.|  |..||..:.|.:.:.||.
  Rat   486 KAYD-GFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSG--QELNVVQIEENSSKSTYK 547

  Fly   275 PNNYNAETAAN--------RICKVLKVNQ--------------------------ENERLMEEYE 305
            ..||..:|.::        .:..:...:|                          |:||...:..
  Rat   548 VGNYETDTNSSVDQEKFYAELSDLKPASQQPASGAVDLLSQDDSVFVTDSGVGESESERQTPDDH 612

  Fly   306 RLASDLLEWIRRTM--------------------PWL----NSRQA------------------D 328
            ...|....:.|||.                    |.|    :|.||                  |
  Rat   613 LSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGLSSSTDSAQALILLGKKRLPKAEDLELRD 677

  Fly   329 NSLAGVQKKLEEYRTYRRKHKP--PR--VEQKAKLETNFNTLQTKL---------RLSNRPAYLP 380
            ..::|.:|.:....||.:|.:|  ||  |||: |:| |..:|:.:|         ||| .|:.|.
  Rat   678 LYVSGKKKDVSLPSTYEQKLQPVNPRSDVEQE-KIE-NSRSLECRLDGELAIQKPRLS-PPSKLG 739

  Fly   381 TEGKTVSDISN----SWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEM 441
            ......:|.:|    |.:.:|....       |:...|...:|.::..:|:..:.::..:.:..:
  Rat   740 YSYNRDTDFTNKPCASLRQIESDPD-------ADKSTLNHADHASKPVQHRMLSRQEELKERARV 797

  Fly   442 LQSQDFRQCKLNELKALKKKHEAFESDLAAHQ-------DRVEQIAAIAQELNTLEYHDCVSVNA 499
            |..|..|..   ..||..|...:....|.:.|       :|..|:...|::|         ...|
  Rat   798 LLEQARRDA---AFKAGSKHGGSTAPALCSRQLNDRQDEERRRQLRERARQL---------IAEA 850

  Fly   500 RCQRICDQWDRLG-----ALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVD 559
            ||.....:....|     .|.:|.:.:.||.:.|  :||                   |.|:..:
  Rat   851 RCGVKMSELPSYGEMAAEKLKERSKASGDENDNI--EID-------------------TNEESPE 894

  Fly   560 MFIVHTMEEIQGLIQAHD-----------QFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGL 613
            .|:|...:|:..:....|           :.|..|....:..|.:.:..::..:...:.....|:
  Rat   895 GFVVGGGDELTNIESDLDTPEQNSKLVDLRLKKLLDAQPQVANSLSSAAQKAATDTSEQGEKNGM 959

  Fly   614 ENPYTTLTANDMTR--------KWSDVRQLVPQR-DQTLAN--ELRKQQN-NEMLRRQFAEKANI 666
            |:..|........|        |.|.||:...|. .|.:.|  |:::|:: .|...|...|||.|
  Rat   960 EDLRTERLQKATERFRNPVVFNKDSTVRKTQLQSFSQYVENRPEMKRQRSIQEDTERGDEEKAMI 1024

  Fly   667 VGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYT 731
            .....:...|.|...|             .|:..|.|......:|..:|  |....:.:.|.| .
  Rat  1025 TEAQRKPSEDEVLNKG-------------FKDTSQYVVGELAALENEQK--QIDTRAALVEKR-L 1073

  Fly   732 NYTMETLRVGWEQLLTSINRNINEVENQI----LTRDSKGISQEQLNEFRSSFNHFDKNRTGRLS 792
            .|.|:|            .||..|.|..:    :..:.|.....::|:........|..|...|.
  Rat  1074 RYLMDT------------GRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELL 1126

  Fly   793 PEEFKSCLVSLGY--SIGKDRQGDLDFQRILAVVDPNNTGYVHFDAF---LDFMTRESTDTD--- 849
            ..|.::.|....:  :..:.|:..|....::|:||..       ||.   ||...:::.:.|
  Rat  1127 NRELRAMLAIEDWQKTEAQKRREQLLLDELVALVDKR-------DALVRDLDAQEKQAEEEDEHL 1184

  Fly   850 --TAEQ 853
              |.||
  Rat  1185 ERTLEQ 1190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063
		CH_ACTN_rpt2	139..252	CDD:409065	39/106 (37%)
		SPEC	302..525	CDD:238103	58/293 (20%)
		SPEC	420..647	CDD:238103	44/260 (17%)
		SPEC	538..760	CDD:238103	46/244 (19%)
		EFh	775..842	CDD:238008	14/71 (20%)
		EFhand_Ca_insen	847..913	CDD:400872	4/12 (33%)
Ehbp1	XP_006251627.1	NT-C2	12..165	CDD:287345
		CH	427..523	CDD:278723	38/96 (40%)
		OHCU_decarbox	<928..1012	CDD:294768	15/83 (18%)
		DUF3585	1044..1184	CDD:288945	31/161 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900