DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and Sptbn5

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_038962422.1	Gene:	Sptbn5 / 296090	RGDID:	1311047	Length:	3602	Species:	Rattus norvegicus

Alignment Length:	857	Identity:	257/857 - (29%)
Similarity:	389/857 - (45%)	Gaps:	177/857 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MMENGLSM--EYGDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNS--HLRKAGTAIDNIEEDF 62
            ::.:.|:|  ||..|::.:         |.......|:|||..|.|:  .|.:.|..|.|:..:.
  Rat    50 LLSSSLAMDSEYEIGHVRK---------LQAQHTHMQEKTFINWINNIFRLGRVGIRIQNLYTEL 105

  Fly    63 RNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTL 127
            .:|..|:.|||:||||.||.|..|::|.|.:.|.:.||.|:.:| |.:..||.|.||||:..:.|
  Rat   106 ADGAHLLRLLELISGEALPAPSPGRLRVHFLENNSHALAFLRAK-VPVPFIGPENIVDGDQSLIL 169

  Fly   128 GMIWTIILRFAIQDISVEE---------MTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFC 183
            |::|.|||||.|..||::.         ::|||.||:||||:||.|.||::.:|..|:.|||||.
  Rat   170 GLLWVIILRFQISHISLDREEFGASAALLSAKEALLVWCQRQTASYSNVDITDFSRSWSDGLAFN 234

  Fly   184 ALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCY 248
            ||:|.|||||:||..||.|.||.||:.||.|||:.|.|.::||.:| :....||||:||||||.|
  Rat   235 ALLHAHRPDLLDYGSLSLDRPLYNLSFAFRVAEQQLGIAQLLDAED-VAARHPDERSIMTYVSQY 298

  Fly   249 YHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLE 313
            ||.|...||                      .:||..|:.|||...||.|.|..:||:||:|||.
  Rat   299 YHYFSRLQQ----------------------GQTARRRLAKVLLQLQETEVLQAQYEQLAADLLC 341

  Fly   314 WIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAY 378
            ||......|.::...:||..:::.|..:.::|.:.||||::|:...||....|||.||..||..:
  Rat   342 WIEEKQMQLEAQDFPDSLPAMRQLLSAFASFRAQEKPPRLQQQGASETLLFQLQTTLRAQNRRPF 406

  Fly   379 LPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQ 443
            ||.||...::::..|..||..|.:..:.:..:.::||||:.||::|:.||...|.:....|:||:
  Rat   407 LPREGLGPAELAQCWAELERVEASRSQAMQQKLLQLERLDTLARRFQCKASHRESFLNDAEQMLE 471

  Fly   444 SQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQW 508
            ...........::|..::....|:.|...:.|.:.:..:|..|...|||....|..|.:.|..:|
  Rat   472 QARASLTDPATVEAATQRLNMLEAGLLPQEGRFQALGEMADILQQEEYHSWADVACRQKEITGRW 536

  Fly   509 DRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQG-- 571
            .||....|..|..|...:.:|..:.  .:|.|                      ...:.|:||
  Rat   537 RRLLQCLQEERKCLAGTQAVLSLLQ--EVEAA----------------------TDQLGELQGLA 577

  Fly   572 --------------LIQAHDQFKATLGEADKEFNLIVNLVREVES---------------IVKQH 607
                          |:|:||..:|.:.......|.:|:...:::|               :.:.|
  Rat   578 GSTACEPQLAEVVLLLQSHDLLEAQVSAHRTHVNRLVHQTAQLDSSQGTSVQTLQTKALALDELH 642

  Fly   608 QIPGGLENPYTTLTANDMTR-----------KW-SDVRQLV----PQRDQT-LANELRKQQ--NN 653
            .....|.....||....:.|           .| .:.||||    |.||.| :||.|:|.:  ..
  Rat   643 HSLVSLVRTRRTLLEQTLQRAQFLHSCEEEEAWLQEHRQLVEKAAPGRDLTQIANALQKHKALET 707

  Fly   654 EMLRRQFA-----------------------EKANIV-GPW-------IERQMDAVTAIGMG--- 684
            |:.|.|..                       |:|..| |.|       ..|:....||:.:|
  Rat   708 ELHRHQAVCIDLMQRGRNLSVKEPLTQPDPLERAEAVQGIWQLLWTGAARRRTRLQTALLVGQYF 772

  Fly   685 --LQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLT 747
              |..:....|.|.|:.|.|.|..          .|:..|:::         .:.||:  ||.|.
  Rat   773 SDLAEAASWLLQRQKQLESASYGK----------DQSDSEALL---------QQHLRL--EQGLC 816

  Fly   748 SINRNINEVENQ 759
            :...::.|:|:|
  Rat   817 AFAVDLRELEDQ 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	42/105 (40%)
		CH_ACTN_rpt2	139..252	CDD:409065	64/121 (53%)
		SPEC	302..525	CDD:238103	67/222 (30%)
		SPEC	420..647	CDD:238103	57/274 (21%)
		SPEC	538..760	CDD:238103	60/308 (19%)
		EFh	775..842	CDD:238008
		EFhand_Ca_insen	847..913	CDD:400872
Sptbn5	XP_038962422.1	CH_SPTBN5_rpt1	57..181	CDD:409096	51/133 (38%)
		CH_SF	196..304	CDD:412120	62/108 (57%)
		SPEC	331..548	CDD:413338	65/216 (30%)
		SPEC	448..660	CDD:238103	45/235 (19%)
		SPEC	664..>831	CDD:238103	42/186 (23%)
		SPEC	770..1018	CDD:238103	17/80 (21%)
		SPEC	1126..1222	CDD:197544
		SPEC	1227..1432	CDD:238103
		SPEC	1333..1534	CDD:238103
		SPEC	1536..1738	CDD:238103
		SPEC	1742..1953	CDD:238103
		SPEC	1852..2058	CDD:238103
		SPEC	2059..2262	CDD:238103
		SPEC	2163..2368	CDD:238103
		SPEC	2371..2566	CDD:238103
		SPEC	2472..2681	CDD:238103
		SPEC	2684..2894	CDD:238103
		SPEC	2895..3106	CDD:238103
		SPEC	3001..3213	CDD:238103
		Spectrin	3213..3320	CDD:395348
		SPEC	3325..>3488	CDD:238103
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920