Protein Alignment Actn and SYNE1

DIOPT Version :10

• Sequence 1: NP_477485.1
• Gene: Actn / 31166
• FlyBaseID: FBgn0000667
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_006715470.1
• Gene: SYNE1 / 23345
• HGNCID: 17089
• Length: 8846
• Species: Homo sapiens
• Alignment Length: 1149
• Identity: 254/1149 - (22%)
• Similarity: 444/1149 - (38%)
• Gaps: 355/1149 - (30%)

  Fly    36 QKKTFTAWCNSHL--RKAGTAIDNIEEDFRNGLKLMLLLEVISGETLP-KPDRGKMRFHKIANVN 97
            ||:|||.|.||||  ||....:|::.||.::|:||:.||||:||:.|| :..|...|.|.:||:.
Human    29 QKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRRMKRIHAVANIG 93

  Fly    98 KALDFI-ASKGVH------LVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDI------------- 142
            .||.|: ..|.:|      ||:|.:.:|.||...:.||::|||||.|.|:::
Human    94 TALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSS 158

  Fly   143 --SVEEM--------------------TAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCAL 185
              ||:.:                    .||:.||.|.|........:.|::|..|::.|:||.::
Human   159 ASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSV 223

  Fly   186 IHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYH 250
            ||..||:|:|...:...:..|||..||.:||..|.|||:|||:| ::..||||::|||||:.:
Human   224 IHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPED-VDVDKPDEKSIMTYVAQF-- 285

  Fly   251 AFQGAQQVGNVTHVPEPTRQYT-------YVP---------NNYNAE------------------ 281
                      :.|.|:.....|       .:|         .|:..|
Human   286 ----------LKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERD 340

  Fly   282 -TAANRI----------CKVLKVNQENER----------------------LMEEYERLASDLLE 313
             |.|..:          .|..:|..|.:|                      :.:.::|:.|.|.:
Human   341 LTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFD 405

  Fly   314 W---IRRTMP--------WL-----------NSRQADNSLAG-VQKKLEEYR------------- 342
            |   :.:::|        ||           ..:|.....|. :|:|||:::
Human   406 WHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAF 470

  Fly   343 --TYRRKH------KPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELA 399
              .||.:.      .|.::|..|: ..:|.:..::|.|. :..:|..:.:.:|       .|.||
Human   471 HEIYRTRSVNGIPVPPDQLEDMAE-RFHFVSSTSELHLM-KMEFLELKYRLLS-------LLVLA 526

  Fly   400 EKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEA 464
            |...:.|:: :..|.|.:|.|.|.:....:             .|:.|.|.::. .:.||:..|.
Human   527 ESKLKSWII-KYGRRESVEQLLQNYVSFIE-------------NSKFFEQYEVT-YQILKQTAEM 576

  Fly   465 F-ESDLAAHQDRVEQIAAIAQELN--TLEYH----DCVSVNARCQRICDQWDRLGALTQRRRTAL 522
            : ::|     ..||:...:.:.:|  |.::.    :..||.:..:.:...|||.|......:..|
Human   577 YVKAD-----GSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWL 636

  Fly   523 DEAERILEKIDILHLEFAKRAAPFNN---WL-DGTREDLVDMFIVHTMEEI------QGLIQAHD 577
            ::||::|.:.:....:|      |.|   |: ..|..:....|::.|.:|:      |.|:..:.
Human   637 EDAEKMLNQSENAKKDF------FRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNG 695

  Fly   578 QFK---------ATLGEAD---KEF-NLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKW 629
            :::         |...|.|   ||: :.:|.|........|:...|..:......|...|:
Human   696 RWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDL---- 756

  Fly   630 SDVRQLVPQRD----------QTLANELRKQQNNEM------LRRQFAEKANIVGPW-------- 670
            .|:.|.||..|          ..:..|..:::..||      |:.|..:......|.
Human   757 EDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLL 821

  Fly   671 -----IERQM-----------DAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEE----LEK 715
                 :|:||           :.:|.:....|.|.     ..|:..|.:.|.:.|.::    :||
Human   822 IPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA-----LFKQKHQELLACQENCKKTLTLIEK 881

  Fly   716 IHQAVQESMIFENRYTNYTMETL----------------RVG-WEQLLTSINRNINEVE------ 757
            ..|:||:.:...|...::....|                :.| |::.:.:.:|.:.:.|
Human   882 GSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAEL 946

  Fly   758 NQILT-----RDSKGISQEQLNEFRSSFNHFDK----------NRTGRLSPEEFKSCL---VSLG 804
            .::|.     .:.||..:|.|......|:..|:          :....:.||:.:..|   |...
Human   947 EKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKL 1011

  Fly   805 YSIGKDRQG-----------DLDFQRILAVVDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSF 858
            :...||.||           |::..|.||.|:...|   ..|.....|.:|.     :|::|...
Human  1012 HKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRT---ELDRETKLMPQEG-----SEKIIKEH 1068

  Fly   859 RILAADK-PYILPDELRRELPPDQAEYCIQRMPPYKGP-NGVPG 900
            |:..:|| |:.| .|.|.:|   ..|.|::.  |.:.| ...||
Human  1069 RVFFSDKGPHHL-CEKRLQL---IEELCVKL--PVRDPVRDTPG 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_477485.1	CH_ACTN_rpt1	31..135	CDD:409063	47/108 (44%)
		CH_ACTN_rpt2	139..252	CDD:409065	45/147 (31%)
		SPEC	302..525	CDD:238103	51/273 (19%)
		SPEC	420..647	CDD:238103	49/266 (18%)
		SPEC	538..760	CDD:238103	53/311 (17%)
		EFh	775..842	CDD:238008	17/90 (19%)
		EFhand_Ca_insen	847..913	CDD:430177	16/56 (29%)
SYNE1	XP_006715470.1	CH_SYNE1_rpt1	24..143	CDD:409090	50/113 (44%)
		CH_SYNE1_rpt2	182..290	CDD:409092	43/120 (36%)
		SMC_prok_B	1256..>2073	CDD:274008
		SMC_prok_B	2340..3123	CDD:274008
		SPEC	2417..2622	CDD:238103
		SPEC	3072..3283	CDD:238103
		SPEC	3184..3395	CDD:238103
		SPEC	3397..3602	CDD:413338
		SPEC	3824..4042	CDD:238103
		SPEC	4148..4344	CDD:413338
		SPEC	4273..4459	CDD:413338
		SMC_prok_B	4970..5805	CDD:274008
		SMC_prok_B	5944..6730	CDD:274008
		SPEC	6808..7030	CDD:413338
		SPEC	6926..7137	CDD:238103
		SPEC	7046..7244	CDD:238103
		SPEC	7173..7361	CDD:413338
		SPEC	7365..7567	CDD:238103
		SPEC	7469..7680	CDD:238103
		COG4913	<7677..>7878	CDD:443941
		SPEC	7793..8008	CDD:238103
		SPEC	8012..8222	CDD:238103
		SPEC	8476..8709	CDD:238103
		KASH	<8814..8845	CDD:463142