DRSC/TRiP Functional Genomics Resources

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Protein Alignment Actn and EHBP1

DIOPT Version :9

Sequence 1:NP_001259165.1 Gene:Actn / 31166 FlyBaseID:FBgn0000667 Length:917 Species:Drosophila melanogaster
Sequence 2:NP_001341141.1 Gene:EHBP1 / 23301 HGNCID:29144 Length:1231 Species:Homo sapiens


Alignment Length:832 Identity:178/832 - (21%)
Similarity:321/832 - (38%) Gaps:226/832 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 AKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFD 213
            |.:.||:||:..|..|:.|.:.||..|:::||:|||::|..|||||||..|:..:..||...|:|
Human   445 ASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYD 509

  Fly   214 VAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNY 278
             ....:.|.|:|:|.|::....||:..:|||:......|.|  |..||..:.|.:.:.||...||
Human   510 -GFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSG--QELNVVQIEENSSKSTYKVGNY 571

  Fly   279 NAETAANRICKVLKVNQENERLMEEYERLAS-----DLLEWIRRTMPWLNSRQADNSL----AGV 334
            ..:|.::       |:||     :.|..|:.     :|.:.|...:.:|:.   |:|:    :||
Human   572 ETDTNSS-------VDQE-----KFYAELSDLKREPELQQPISGAVDFLSQ---DDSVFVNDSGV 621

  Fly   335 QKKLEEYRT------------YRRKHKPPRVEQKAK-------------LETNFNTLQTKLRLSN 374
            .:...|::|            |.|:.|.....||::             :.:|.::.|.::.|..
Human   622 GESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQVLLGK 686

  Fly   375 RPAYLPTEGKTVSD--ISNSWKGLE---LAEKAFEEWL----LAETMRLERLEHLAQKFKHKADA 430
            : ..|..|...:||  :|:..|.:.   :.|:..|:.|    :...:..|:||: ::..:.::|.
Human   687 K-RLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKEKLEN-SRSLECRSDP 749

  Fly   431 HEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAF---ESD---------------------LAA 471
            .....  |..:..:.........:|...||||.:.   |||                     |.:
Human   750 ESPIK--KTSLSPTSKLGYSYSRDLDLAKKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLS 812

  Fly   472 HQDRVEQIAAIAQE-------LNTLEYHDCVSVNARCQR-ICDQWD--RLGALTQRRRTALDEA- 525
            .|:.:::.|.:..|       |.....|:..:....|.| :.||.|  |...|.:|.|..:.|| 
Human   813 RQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEAR 877

  Fly   526 ------------ERILEKIDILHLEFAKRAAPFNNWLD-GTREDLVDMFIVHTMEEIQGLIQAHD 577
                        |...||:.    |.:|.:...|:.:: .|.|::.:.|:|...:|:..|....|
Human   878 SGVKMSELPSYGEMAAEKLK----ERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNLENDLD 938

  Fly   578 QFKATLGEADKEFNLIVNLVREVESIV---------------KQHQIPGGLE------------- 614
                |..:..|..:|.:..:.||:..|               .:..:..|.|             
Human   939 ----TPEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTER 999

  Fly   615 --NPYTTLTANDMTRKWSDV--------------RQLVPQRDQTLANE--------LRKQQNNEM 655
              ||  .:.:.|.|.:.:.:              ||...|.|....||        .||...:|:
Human  1000 FRNP--VVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEV 1062

  Fly   656 LRRQFAEKAN-IVGPWI-----ERQMDAVTAIG-------MGLQGSLEDQLHRLKEY------EQ 701
            |.:.|.:.:. :||...     ::|:|...|:.       |....:.|::...::|:      :.
Human  1063 LNKGFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKN 1127

  Fly   702 AVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRV-----GWEQ----------LLTSINR 751
            |:......:..|||.|.       .|.||.....| ||.     .|::          ||..:..
Human  1128 ALIRRMNQLSLLEKEHD-------LERRYELLNRE-LRAMLAIEDWQKTEAQKRREQLLLDELVA 1184

  Fly   752 NINEVENQILTRDSKGISQEQLNEFRSSFNHFDK---NRTGRLSPEEFKSCL 800
            .:|:.:..:...|::....|:.:|      |.::   ...|:::.:|.|..|
Human  1185 LVNKRDALVRDLDAQEKQAEEEDE------HLERTLEQNKGKMAKKEEKCVL 1230

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ActnNP_001259165.1 CH_ACTN_rpt1 31..135 CDD:409063
CH_ACTN_rpt2 139..252 CDD:409065 39/102 (38%)
SPEC 302..525 CDD:238103 56/299 (19%)
SPEC 420..647 CDD:238103 58/326 (18%)
SPEC 538..760 CDD:238103 56/308 (18%)
EFh 775..842 CDD:238008 6/29 (21%)
EFhand_Ca_insen 847..913 CDD:400872
EHBP1NP_001341141.1 NT-C2 12..165 CDD:313563
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..318
NPF <274..383 CDD:318744
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 358..440
CH 447..549 CDD:306753 39/102 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 616..675 9/58 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 737..764 4/29 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 777..800 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 837..865 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 895..941 12/53 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 960..996 3/35 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1065 10/39 (26%)
DUF3585 1074..1210 CDD:314926 26/149 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1198..1231 7/39 (18%)
CAAX motif. /evidence=ECO:0000305|PubMed:27552051 1228..1231 1/3 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0035
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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