DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and Ehbp1

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_011241983.1	Gene:	Ehbp1 / 216565	MGIID:	2667252	Length:	1257	Species:	Mus musculus

Alignment Length:	870	Identity:	186/870 - (21%)
Similarity:	325/870 - (37%)	Gaps:	239/870 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 EEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLN 209
            ::..|.:.||.||:..|..|:.|.:.||..|:::||:|||::|..|||||||..|:..:..||..
Mouse   451 QKPNASQSLLAWCREVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNK 515

  Fly   210 TAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYV 274
            .|:| ....:.|.|:|:|.|::....||:..:|||:......|.|  |..||..:.|.:.:.||.
Mouse   516 KAYD-GFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSG--QELNVVQIEENSSKSTYK 577

  Fly   275 PNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQA------DNSL-- 331
            ..||..:|.::       |:|         |:..::|.:..|...|...:|.|      |:|:
Mouse   578 VGNYETDTNSS-------VDQ---------EKFYAELSDLKREPEPHQPARGAVDLLSQDDSVFV 626

  Fly   332 --AGVQKKLEEYRT------------YRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTE 382
              :||.:...|::|            |.|:.|.....||::        |:..|         |.
Mouse   627 TDSGVGESESEHQTPDDHLSPSTASPYYRRTKSDTEPQKSQ--------QSSAR---------TS 674

  Fly   383 GKTVSDISNSWKGLELAEKAFEEWLLAETMRL------------ERLEHLAQKFKHKADAHEDWT 435
            |.....:|:|....:......::.|.||.:.|            ..|....||.: ...|..|..
Mouse   675 GSDDPGLSSSTDSAQALASLGKKRLKAENLELSDLCVSDKKKDVSPLSAYEQKLQ-TVHASSDME 738

  Fly   436 RGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQD---RVEQIAAIAQ-------ELNTLE 490
            :||.|..:|   .:|:|:...|:.|.:.:..|.|..::|   ..:..|::.|       :.:||.
Mouse   739 QGKMEKSRS---LECRLDGELAITKPNVSSPSKLGYNRDTDFTKKPCASLRQIESDPDADKSTLN 800

  Fly   491 YHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAER-ILEKIDILHLEFAKRAAP------FNN 548
            :.|..:...:.:.:..|.:    |.:|.|..|::|.| ...|:...|   ...|||      .|:
Mouse   801 HADHPNKAVQHRMLSRQEE----LKERARVLLEQARRDAAFKVGSKH---GGSAAPALCSRQLND 858

  Fly   549 WLD-GTREDLVDMFIVHT-------MEEIQGLIQAHDQFKATLGEA------------------- 586
            ..: |.::..|  |.|:|       .::.:...|..::.:..:.||
Mouse   859 VRNTGCKKHTV--FTVNTAVMGRRGQQDEERRRQLRERARQLIAEARCGVKMSELPSYGEMAAEK 921

  Fly   587 ---------DKEFNLIVNLVREV-ESIVKQHQIPGG---------LENPYTTLTANDMTRK---- 628
                     |:..|:.::...|: |..|    :.||         |:||.......|:..|
Mouse   922 LKERSKASGDENDNIEIDTNEEIPEGFV----VGGGDELTNIESDLDNPEQNSKVVDLRLKKLLE 982

  Fly   629 -WSDVRQLVP---QRDQTLANELRKQQNNEMLRRQFAEKAN------IV---------------G 668
             ...|..|:|   |:..|.|:|..::...|.||.:..:||.      :|               .
Mouse   983 AQPQVANLLPSAAQKAVTEASEQGEKSGVEDLRTERLQKATERFRNPVVFNKDSTVRKTQLQSFS 1047

  Fly   669 PWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAV--YAYKPNIEEL------EKIHQAVQESMI 725
            .::|.:.:      |..|.|:::...|..|.:..:  ...||:.:|:      :.....|.|...
Mouse  1048 QYVENRPE------MKRQRSIQEDTKRGTEEKAEITETQRKPSEDEVLNKGFKDTSQYVVGELAA 1106

  Fly   726 FEN-------------RYTNYTMETLRVGWEQLLTSINRNINEVENQI----LTRDSKGISQEQL 773
            .||             :...|.|:|            .||..|.|..:    :..:.|.....::
Mouse  1107 LENEQKQIDTRAALVEKRLRYLMDT------------GRNTEEEEAMMQEWFMLVNKKNALIRRM 1159

  Fly   774 NEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGY--SIGKDRQGDLDFQRILAVVDPNNTGYVHFDA 836
            |:........|..|...|...|.::.|....:  :..:.|:..|....::|:||..       ||
Mouse  1160 NQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVDKR-------DA 1217

  Fly   837 F---LDFMTRESTDTD-----TAEQ 853
            .   ||...:::.:.|     |.||
Mouse  1218 LVRDLDAQEKQAEEEDEHLERTLEQ 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063
		CH_ACTN_rpt2	139..252	CDD:409065	39/106 (37%)
		SPEC	302..525	CDD:238103	53/266 (20%)
		SPEC	420..647	CDD:238103	59/297 (20%)
		SPEC	538..760	CDD:238103	57/323 (18%)
		EFh	775..842	CDD:238008	14/71 (20%)
		EFhand_Ca_insen	847..913	CDD:400872	4/12 (33%)
Ehbp1	XP_011241983.1	NT-C2	12..165	CDD:371003
		CH	457..559	CDD:366016	39/102 (38%)
		SbcC	<920..>1253	CDD:223496	65/352 (18%)
		DUF3585	1100..1236	CDD:371910	28/154 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900