DRSC/TRiP Functional Genomics Resources

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Protein Alignment Actn and Sptbn2

DIOPT Version :9

Sequence 1:NP_001259165.1 Gene:Actn / 31166 FlyBaseID:FBgn0000667 Length:917 Species:Drosophila melanogaster
Sequence 2:NP_067262.1 Gene:Sptbn2 / 20743 MGIID:1313261 Length:2388 Species:Mus musculus


Alignment Length:855 Identity:293/855 - (34%)
Similarity:423/855 - (49%) Gaps:162/855 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 SMEYGDGYMEQEEEWEREGLLDPAW----------------------EKQQKKTFTAWCNSHLRK 50
            |:|....|.:....|:   |.|..|                      |..||||||.|.||||.:
Mouse    12 SLEIQGQYSDINNRWD---LPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLAR 73

  Fly    51 AGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGA 115
            ....:.::..|.|:|..|:.||||:||||||||.:|:||.|.:.||:|||.|:..:.|||.::|:
Mouse    74 VTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGS 138

  Fly   116 EEIVDGNLKMTLGMIWTIILRFAIQDISV------EEMTAKEGLLLWCQRKTAPYKNVNVQNFHL 174
            .:|||||.::|||::|||||||.||||||      |:.:||:.||||||.|||.|.||||.||..
Mouse   139 HDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTT 203

  Fly   175 SFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDER 239
            |::|||||.|::|:|||||:|:..|.|.|...||..||::|||.|.:.::|||:| :|..:|||:
Mouse   204 SWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPED-VNVDQPDEK 267

  Fly   240 AIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEY 304
            :|:|||:.|||.|...:.:.                      ....||.|||....|.|.|:|:|
Mouse   268 SIITYVATYYHYFSKMKALA----------------------VEGKRIGKVLDHAMEAEHLVEKY 310

  Fly   305 ERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTK 369
            |.|||:||:||.:|:..||.||..|||:|||.:|:.:.:||...|||:..:|..||....|:|:|
Mouse   311 ESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSK 375

  Fly   370 LRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDW 434
            ||.:|:..|.|.||:.:|||:.:|:.||.||...|..|..|.:|.|:||.||.:|..||...|.|
Mouse   376 LRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETW 440

  Fly   435 TRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNA 499
            . .:.:.|.|||....:|..::|..:||||.|:|:.|:..||:.:.|:|.||....|||...:.|
Mouse   441 L-SENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAEHYHDIKRIAA 504

  Fly   500 RCQRICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVH 564
            |...:...||.|..:...||      ||:|     |:||..|           ..:||  ::::.
Mouse   505 RQNNVARLWDFLRQMVAARR------ERLL-----LNLELQK-----------VFQDL--LYLMD 545

  Fly   565 TMEEIQGLIQAHDQFKATLGEAD-------KEFNLIVNL--VREVESIVKQHQIPGGLENPYTTL 620
            .|.|::|.:|:.|..|...|..|       .|.::.|..  ||.|.:...:...||....|... 
Mouse   546 WMAEMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYRPCDP- 609

  Fly   621 TANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEML-------RRQFAEKANI------VG---P 669
                         |||.:|..||      :|:.|.|       |.:..|...:      ||   .
Mouse   610 -------------QLVSERVATL------EQSYEALCELAATRRARLEESRRLWRFLWEVGEAEA 655

  Fly   670 WIERQMDAVTAIGMG---------------LQGSLEDQLHRLK----EYEQAVYAYKP------- 708
            |:..|...:.:...|               |:|.:..:|..||    :.:|.|....|       
Mouse   656 WVREQQHLLASADTGRDLTGVLRLLNKHAALRGEMSGRLGPLKLTLEQGQQLVAEGHPGANQAST 720

  Fly   709 ----------NIEEL--EKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQIL 761
                      .:|.|  |:..|..|.:.:::.:.....||...|...:|::|.....:|...|.|
Mouse   721 RAAELQAQWERLEALAEERAQQLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQAL 785

  Fly   762 TRDSKGISQE 771
            .|..:.:.:|
Mouse   786 ARQHRALEEE 795

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ActnNP_001259165.1 CH_ACTN_rpt1 31..135 CDD:409063 54/125 (43%)
CH_ACTN_rpt2 139..252 CDD:409065 65/118 (55%)
SPEC 302..525 CDD:238103 91/222 (41%)
SPEC 420..647 CDD:238103 67/235 (29%)
SPEC 538..760 CDD:238103 55/284 (19%)
EFh 775..842 CDD:238008
EFhand_Ca_insen 847..913 CDD:400872
Sptbn2NP_067262.1 SAC6 51..>441 CDD:227401 192/412 (47%)
Spectrin 429..522 CDD:334073 32/93 (34%)
SPEC 534..746 CDD:238103 47/244 (19%)
SPEC 749..958 CDD:238103 10/47 (21%)
SPEC 961..1172 CDD:238103
SPEC 1174..1383 CDD:238103
SPEC 1384..1588 CDD:238103
SPEC 1589..1801 CDD:238103
SPEC 1802..2010 CDD:238103
SPEC 2018..>2075 CDD:197544
PH_beta_spectrin 2221..2326 CDD:269975
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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