DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and Sptb

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_038703.3	Gene:	Sptb / 20741	MGIID:	98387	Length:	2329	Species:	Mus musculus

Alignment Length:	1015	Identity:	324/1015 - (31%)
Similarity:	489/1015 - (48%)	Gaps:	244/1015 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WEREGLLDPAWEKQ--QKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPD 84
            :||..:...|.|::  ||||||.|.||||.:....|.::.:|.|:|..|:.||||:|||.||:|.
Mouse    40 FERSRIKALADEREVVQKKTFTKWVNSHLARVSCRISDLYKDLRDGRMLIKLLEVLSGEMLPRPT 104

  Fly    85 RGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----- 144
            :||||.|.:.||:|||.|:..:.|||.::|:.:|||||.::.||:||||||||.||||.|
Mouse   105 KGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169

  Fly   145 -EEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENL 208
             |..:||:.||||||.|||.|.:|||.||..|:||||||.||||:|||||||:.||...|...||
Mouse   170 RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNL 234

  Fly   209 NTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTY 273
            ..||||||:.|.|..:|||:|:. |..|||::|:|||..:||.|...:.:.
Mouse   235 EHAFDVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLA-------------- 284

  Fly   274 VPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKL 338
                    ....|:.||:....|.|:::|:|..||||||.||.:|:..||||:..|||:|||::|
Mouse   285 --------VEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTISVLNSRKFANSLSGVQQQL 341

  Fly   339 EEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAF 403
            :.:.|||...|||:.::|..||....|:|:::|.:|:..|.|.:||.||||:.:|:.||.||...
Mouse   342 QAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYQR 406

  Fly   404 EEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESD 468
            |..|.:|.:|.|:||.||::|..||...|.|. .:.:.|.:||.....|..::|.||||||.|:|
Mouse   407 ELALRSELIRQEKLEQLARRFDRKAAMRETWL-NENQRLVTQDNFGYDLAAVEAAKKKHEAIETD 470

  Fly   469 LAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKI- 532
            .||:::||:.:..:||||....|||...:.||...|...|..|..|.:.||..| ||...|:|:
Mouse   471 TAAYEERVKALEDLAQELEKENYHDQKRIIARKDNILRLWSYLQELLRSRRQRL-EATLALQKLF 534

  Fly   533 -DILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAH-----------DQFK----A 581
             |:||         ..:|:|..:..::.......:.|::.|:|.|           |:.|    |
Mouse   535 QDMLH---------SIDWMDEIKAHILSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAA 590

  Fly   582 TLGEADKE--------------------FNLIVNL--------------------VREVESIVKQ 606
            ||..|:.:                    |:.:.|:                    :.|.||.:|:
Mouse   591 TLQFAEGKGYQPCDPQVIQDRVSHLEQCFSELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKE 655

  Fly   607 HQIPGGLENPYTTLT-ANDMTRKWSDVRQLVPQR-DQTLANELRK---------QQNNEML-RRQ 659
            .      |..|::|. ..|:|      ..|:.|| .:...:|||.         |:.::|: ::|
Mouse   656 K------EQIYSSLDYGKDLT------SVLILQRKHKAFEDELRGLDAHLKQIFQEADDMVAQKQ 708

  Fly   660 FAEKANIVGPWIERQMDAVTAIGMGL--------------------QGSLED------QLHRL-- 696
            |..      |.||.::..|:|....|                    ||..:|      ..|||
Mouse   709 FGH------PQIETRVKEVSAQWDHLKELAAFRKKDLQDAENFFQFQGDADDLKAWLQDAHRLLS 767

  Fly   697 ----KEYEQAVYA----YKPNIEELEKI--------HQA------VQESMIFENRYTNYTMETLR 739
                .:.|.|..|    :|..:||||:.        |||      .::|....||     ::.||
Mouse   768 GEDVGQDEGATRALGKKHKEFLEELEESRGVMEHLEHQAQGFPEEFRDSPDVTNR-----LQALR 827

  Fly   740 VGWEQLLTSINRNINEVENQI---------------LTRDSKGISQ-------EQLNEFRSSFNH 782
            ..::|:||......::::..:               :|...|.:.|       |.|...:..|:.
Mouse   828 KLYQQVLTQAELRGHKLQEALDLYTVFGESDACELWMTEKGKWLDQMDIPNTLEDLEVVQHRFDI 892

  Fly   783 FDKNRTGRLSPEEFKSCLVSL-GYSI--------GKDRQGDL-DFQRILAVVDPNNTGYVHFDAF 837
            .|         :|.|:.:..: |.::        |..|.|:: .:|      |..|..:..|.|.
Mouse   893 LD---------QEMKTLMAQIDGVNLAANNLVESGHPRSGEVKQYQ------DRLNKRWQAFQAV 942

  Fly   838 LDFMTRESTDT------------DTAEQVIDSFRILAADK 865
            :. ..||:.|:            :|::.::|..:::.:.|
Mouse   943 VS-EQREAVDSALRVNNYCVDCEETSKWIMDKTKVVESTK 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	54/105 (51%)
		CH_ACTN_rpt2	139..252	CDD:409065	68/118 (58%)
		SPEC	302..525	CDD:238103	95/222 (43%)
		SPEC	420..647	CDD:238103	73/285 (26%)
		SPEC	538..760	CDD:238103	64/338 (19%)
		EFh	775..842	CDD:238008	13/76 (17%)
		EFhand_Ca_insen	847..913	CDD:400872	4/31 (13%)
Sptb	NP_038703.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Actin-binding	2..275		126/235 (54%)
		CH	55..158	CDD:237981	55/102 (54%)
		CH	177..273	CDD:214479	58/96 (60%)
		Spectrin	302..411	CDD:278843	49/108 (45%)
		Spectrin 1. /evidence=ECO:0000255	303..411		49/107 (46%)
		Spectrin	422..526	CDD:278843	40/105 (38%)
		Spectrin 3. /evidence=ECO:0000255	529..635		19/114 (17%)
		SPEC	530..742	CDD:238103	44/238 (18%)
		Spectrin 4. /evidence=ECO:0000255	638..741		25/120 (21%)
		SPEC	641..848	CDD:238103	50/229 (22%)
		Spectrin 5. /evidence=ECO:0000255	744..846		25/106 (24%)
		SPEC	745..954	CDD:238103	46/229 (20%)
		Spectrin 6. /evidence=ECO:0000255	853..950		20/112 (18%)
		Spectrin 7. /evidence=ECO:0000255	958..1058		3/24 (13%)
		SPEC	962..1168	CDD:238103	3/20 (15%)
		Spectrin 8. /evidence=ECO:0000255	1062..1165
		SPEC	1170..1379	CDD:238103
		Spectrin 9. /evidence=ECO:0000255	1170..1258
		Spectrin 10. /evidence=ECO:0000255	1275..1376
		SPEC	1385..1475	CDD:197544
		Spectrin 11. /evidence=ECO:0000255	1389..1463
		Spectrin 12. /evidence=ECO:0000255	1481..1582
		SPEC	1485..1690	CDD:238103
		Spectrin 13. /evidence=ECO:0000255	1584..1688
		SPEC	1691..1901	CDD:238103
		SPEC	1798..2005	CDD:238103
		Spectrin 15. /evidence=ECO:0000255	1798..1899
		Spectrin 16. /evidence=ECO:0000255	1906..2006
		Spectrin 17. /evidence=ECO:0000255	2013..2073
		Spectrin	2013..>2070	CDD:278843
		PH	2180..2288	CDD:278594
		PH_beta_spectrin	2182..2287	CDD:269975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920