Protein Alignment Actn and anc-1

DIOPT Version :9

• Sequence 1: NP_001259165.1
• Gene: Actn / 31166
• FlyBaseID: FBgn0000667
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_491353.2
• Gene: anc-1 / 172034
• WormBaseID: WBGene00000140
• Length: 8545
• Species: Caenorhabditis elegans
• Alignment Length: 1013
• Identity: 215/1013 - (21%)
• Similarity: 381/1013 - (37%)
• Gaps: 340/1013 - (33%)

  Fly    33 EKQQKKTFTAWCNSHLRKAGTA--IDNIEEDFRNGLKLMLLLEVISGETLP-KPDRGKMRFHKIA 94
            ||.||.|||.|.|.||.:..::  |:::.||.|:|:.|..|:||::||.|. ...|...|.|.||
 Worm    22 EKAQKNTFTRWINFHLEEHSSSGRIEDLFEDIRDGVLLCHLIEVLTGEALAVHKGRVSKRVHHIA 86

  Fly    95 NVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQD------------ISVEEM 147
            |:..||..:..:|:.|::..|.:|.|||.::.||:||.|||.|.|:.            ...||.
 Worm    87 NLTTALTVLRRRGLELINNNAADIADGNPRIVLGLIWQIILHFQIETNMILLREWGWAATGTEEP 151

  Fly   148 T------------------------------AKEGLLLWCQRKTAPYKN---------------- 166
            |                              :|..|....:..::|.:.
 Worm   152 TSSAQPEVVVTAPSPTPSSKKSHSKVSSLSGSKTSLASGEKAPSSPLRQRIASFLTPTKKAPKLT 216

  Fly   167 ---------------VN-----------VQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPL 205
                           :|           |:|....::||:.||||:.|.|||:|...:::..||.
 Worm   217 AQPVKQSVEQVFLRWINAEIGDLVGGRRVENMDKQWRDGILFCALVSRWRPDVISMREVTNANPR 281

  Fly   206 ENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAF------QGAQQVGNVTHV 264
            :||..||::|.::|.:.|:|..:|:: ..|||:|:::||||.:...|      ||.:|    ..:
 Worm   282 DNLELAFNLAHQHLGVRRLLAVEDMM-IEKPDKRSVITYVSQFVRMFGERSPMQGREQ----HEI 341

  Fly   265 PEPTRQYTYV---PNNYNAETAA-------------NRICKVLKVNQENERLME---EYERLASD 310
            .....:.||:   .:..|::..:             |.|. |.|||.:.|.|:|   :::.:...
 Worm   342 FLAWLEATYLLCTRHELNSQECSRIRREFIEHRPLFNTII-VTKVNYDVEELVEIEKKWDCIRET 405

  Fly   311 LLEWIRRT---MP--------W-------------LNSRQADNSLAGVQKKLEEYRTYRR----- 346
            |.::.||:   :|        |             |::..|..::..:||.:.|::.|..
 Worm   406 LEKYARRSERDLPEPFASIATWIAGAEHILSRPLDLDATDAKKTVTMLQKLISEHQKYMEDLPKR 470

  Fly   347 --------KH-----KP---------------------PRVEQKAKLETNFNTLQ---------- 367
                    ||     :|                     ||:.....|.|::..||
 Worm   471 QEDFEEAVKHGGLGGRPVAPEFSEPLRARFAQIEEENEPRISTLRILTTHYILLQYLQHIDEKII 535

  Fly   368 ------------------TKLRLSNRPA----YLPTEGKTVSDISNSWKGLE---------LAE- 400
                              |:|...|..|    |:.....|:::..||....|         .||
 Worm   536 LWRTADSVTLLLRWIKEYTQLNAENPQAKCASYINKITLTMANDQNSKLDKEAILNTSNEKTAET 600

  Fly   401 -KAFEE-WLLAETMRLERLE---HLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKK 460
             |.||. |:..:.:::|.:|   |::|               .||:::.:     :.|.:....:
 Worm   601 LKRFESLWIELKLLKVEWVEWETHVSQ---------------LEEIIEER-----RRNGVPPTPE 645

  Fly   461 KHEAFESDLAAHQDRVEQIAAIA-----QELNTLEY------HDCVSVNAR------------CQ 502
            ..:|.....|.......::.|.|     |.|:.|.:      ...:.:..|            ..
 Worm   646 DEQALAVITAGADQLAPKLGASARLSNNQRLDVLTHSFKKLTKTTIKIGGRLVVELEPSTSEQAS 710

  Fly   503 RICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDG--TREDLVDMFIVHT 565
            :|...|.....|.:......|..:|..:..|...||:  ||..|.|..|.  ..|.|.:::..|:
 Worm   711 KISYSWQASDELLKVEMQLRDRIQRDADSSDREQLEY--RAETFRNIRDKLIELERLNEIYDNHS 773

  Fly   566 MEEI----QGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMT 626
            .:::    :.||: ||......|....::...|:|........:.:|:|       ..||.|.::
 Worm   774 RDQVDTPNRNLIR-HDMGTIIYGLQAGQYANFVDLSCYAFVYDEYNQVP-------VNLTENVLS 830

  Fly   627 RKWSDVRQLVPQRDQTLANELRKQQNNEMLR---RQFAEKANIVGPWIERQMDAVTAIGMGLQGS 688
            ..:  ||::|.::...|.   |::.|.:.:|   |...|...|:..|...:::.:.|
 Worm   831 EDY--VREIVNRKKAILT---RRENNEDEIRESIRDMEECDRIIEGWQSTEIEELRA-------- 882

  Fly   689 LEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESM---------IFENRYTNYTME------TL 738
              :...:|.|:|    ::...::::|.:.|.:|..:         |.:.|  :|.::      ||
 Worm   883 --EWNIKLSEFE----SWHEMMQQVEVLSQTIQTRLDVTVIQTIWILKER--SYDIKHSELGGTL 939

  Fly   739 RVGWEQLL----TSINRNINEVENQILTRDSKGISQEQ 772
            |...|||.    ||:||::..:|          :|.||
 Worm   940 RESLEQLATTSETSVNRHLQNLE----------LSNEQ 967

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	43/104 (41%)
		CH_ACTN_rpt2	139..252	CDD:409065	40/196 (20%)
		SPEC	302..525	CDD:238103	55/358 (15%)
		SPEC	420..647	CDD:238103	44/255 (17%)
		SPEC	538..760	CDD:238103	53/249 (21%)
		EFh	775..842	CDD:238008
		EFhand_Ca_insen	847..913	CDD:400872
anc-1	NP_491353.2	CH	25..125	CDD:278723	40/99 (40%)
		CH	223..323	CDD:278723	33/100 (33%)
		mycoplas_twoTM	<1952..>2078	CDD:275320
		SbcC	2272..2886	CDD:223496
		DUF2317	<3180..3300	CDD:302887
		Smc	4938..5774	CDD:224117
		DUF2317	<5037..5157	CDD:302887
		Smc	5841..6677	CDD:224117
		DUF2317	<5940..6060	CDD:302887
		Smc	6744..7580	CDD:224117
		DUF2317	<6843..6963	CDD:302887
		Smc	7647..8391	CDD:224117
		DUF2317	<7746..7866	CDD:302887
		KASH	8492..8544	CDD:287506

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910