DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and Actn2

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_150371.4	Gene:	Actn2 / 11472	MGIID:	109192	Length:	894	Species:	Mus musculus

Alignment Length:	918	Identity:	616/918 - (67%)
Similarity:	750/918 - (81%)	Gaps:	30/918 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MENGLSMEY---GDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRN 64
            :|.|:...|   .|.||.|||||:|:.||||||||||:||||||||||||||||.|:||||||||
Mouse     4 IEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRN 68

  Fly    65 GLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGM 129
            ||||||||||||||.||||||||||||||||||||||:||||||.|||||||||||||:||||||
Mouse    69 GLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGM 133

  Fly   130 IWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLI 194
            |||||||||||||||||.:||||||||||||||||:|||:||||.|:||||..||||||||||||
Mouse   134 IWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLI 198

  Fly   195 DYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVG 259
            ||:||:||:|:.|:|.|.::|||:||||:|||.:|::||||||||||||||||:||||.||:|
Mouse   199 DYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQ-- 261

  Fly   260 NVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNS 324
                                ||||||||||||.|||||||||||||||||:||||||||:|||.:
Mouse   262 --------------------AETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLEN 306

  Fly   325 RQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDI 389
            |..:.::..:|||||::|.||||||||:|::|.:||.||||||||||:|||||::|:|||.||||
Mouse   307 RTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDI 371

  Fly   390 SNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNE 454
            :.:|:.||.|||.:|||||.|..|||||||||:||:.||..||.|..|||::|..:|:....|.|
Mouse   372 AGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436

  Fly   455 LKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRR 519
            ::||.:|||||||||||||||||||||||||||.|:|||.|:||.|||:|||||||||.|||:||
Mouse   437 VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRR 501

  Fly   520 TALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLG 584
            .||:..|::||.||.|||||||||||||||::|..|||.||||||::||||.||.||:||||||.
Mouse   502 EALERTEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLP 566

  Fly   585 EADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRK 649
            |||.|...|:.:..|||.:::.:.|.....|||:|:|.:::..||..|:||||.|||:|..||.:
Mouse   567 EADGERQSILAIQNEVEKVIQSYSIRISSSNPYSTVTMDELRNKWDKVKQLVPVRDQSLQEELAR 631

  Fly   650 QQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELE 714
            |..||.||||||.:||.:||||:.:|:.:....:.:.|:||||:::||:||..:..||.||::||
Mouse   632 QHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLE 696

  Fly   715 KIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSS 779
            ..||.:||:::|:|::||||||.:|||||.|||:|.|.|||||.||||||:|||:|||:||||:|
Mouse   697 GDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRAS 761

  Fly   780 FNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAVVDPNNTGYVHFDAFLDFMTRE 844
            |||||:.:.|.:..|:|::||:|:||.:     |:.:|.||:.:||||..|.|.|.:|:||||||
Mouse   762 FNHFDRRKNGLMDHEDFRACLISMGYDL-----GEAEFARIMTLVDPNGQGTVTFQSFIDFMTRE 821

  Fly   845 STDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFST 909
            :.|||||||||.||||||:||||||.:|||||||||||:|||:|||||.||..|||||||.:||:
Mouse   822 TADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPPYSGPGSVPGALDYTAFSS 886

  Fly   910 ALYGETDL 917
            |||||:||
Mouse   887 ALYGESDL 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	96/103 (93%)
		CH_ACTN_rpt2	139..252	CDD:409065	87/112 (78%)
		SPEC	302..525	CDD:238103	151/222 (68%)
		SPEC	420..647	CDD:238103	140/226 (62%)
		SPEC	538..760	CDD:238103	121/221 (55%)
		EFh	775..842	CDD:238008	31/66 (47%)
		EFhand_Ca_insen	847..913	CDD:400872	53/65 (82%)
Actn2	NP_150371.4	Actin-binding	1..254		202/249 (81%)
		CH_ACTN_rpt1	35..139	CDD:409063	96/103 (93%)
		CH_ACTN_rpt2	143..257	CDD:409065	88/113 (78%)
		Spectrin 1	281..391		74/109 (68%)
		Spectrin	281..391	CDD:395348	74/109 (68%)
		Spectrin 2	401..506		72/104 (69%)
		SPEC	402..629	CDD:238103	140/226 (62%)
		Spectrin 3	516..627		64/110 (58%)
		Spectrin 4	637..740		54/102 (53%)
		Spectrin	637..739	CDD:395348	53/101 (52%)
		PTZ00184	747..>851	CDD:185504	64/108 (59%)
		EFhand_Ca_insen	824..890	CDD:400872	53/65 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I3084
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1284	1.000	Inparanoid score	I165
Isobase	1	0.950	-	0	Normalized mean entropy	S998
OMA	1	1.010	-	-		QHG54323
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	1	1.000	-	-		FOG0000815
OrthoInspector	1	1.000	-	-		otm43875
orthoMCL	1	0.900	-	-		OOG6_101135
Panther	1	1.100	-	-	O	PTHR11915
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R34
SonicParanoid	1	1.000	-	-		X512
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820