Protein Alignment Actn and Ehbp1l1

DIOPT Version :10

• Sequence 1: NP_477485.1
• Gene: Actn / 31166
• FlyBaseID: FBgn0000667
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_030106561.1
• Gene: Ehbp1l1 / 114601
• MGIID: 3612340
• Length: 1730
• Species: Mus musculus
• Alignment Length: 517
• Identity: 114/517 - (22%)
• Similarity: 188/517 - (36%)
• Gaps: 167/517 - (32%)

  Fly   147 MTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTA 211
            :::.:.||.|||..|..|:.|.:.||..|:::||||||::||..||.|||..|...|..:|...|
Mouse  1222 VSSSQSLLEWCQEVTNGYRGVCITNFTTSWRNGLAFCAILHRFYPDKIDYFSLDPLNIKQNNKQA 1286

  Fly   212 FDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAF----------------QGAQQVGN 260
            || ....|.:.|:|:|.|::....||:..:|||: |...||                .|..:|||
Mouse  1287 FD-GFAALGVSRLLEPADMVLLSVPDKLIVMTYL-CQIRAFCTGQELQLVQLEGGGGSGTYRVGN 1349

  Fly   261 VTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRR---TMPWL 322
            .    :|:     :|:..:|...|             :||.|....:.::..|.:.|   .:|.:
Mouse  1350 A----QPS-----LPDCLDAGDLA-------------QRLREHGAEVPTEPKEAVNRGTGAIPKV 1392

  Fly   323 NSRQADNS------------------------------------------------LAGVQKKLE 339
            .||..|.|                                                ::||:.:..
Mouse  1393 ASRDTDLSCSSKDGEAEVAQEAIPQEAPTDGPRARSSTTPVVPAEGLVNGVGASGGVSGVRLRRS 1457

  Fly   340 EYRTYRRKHKPPRVEQKAKLETNFNTL---QTKLRLSNR-------------------------- 375
            ..........|||.........:.:.|   :::||.||.
Mouse  1458 SVNGEAGPVPPPRAHGSFSHVRDADLLKKRRSRLRNSNSFSVDDQDSGAAVGAGPAGPGAVEGPN 1522

  Fly   376 ----------PAYLPTE---GKTVSDISNSWKGLELAEKAFE---EWLLAETMRLER-------- 416
                      ||..|.:   |...::.|:...|.|...:.|:   :::.||...||:
Mouse  1523 PASSPDANPLPAPAPQQPPGGPPPTEESSPSLGEETGLQRFQDTSQYVCAELQALEQEQGQIDGR 1587

  Fly   417 -----------LEHLAQKFKHKADAHEDWT--RGKEEMLQSQDFRQCKLNELKALKKKHEAFESD 468
                       :|..|.:.:.:....|.:|  ..|..:::.||..|..:.| :.|:::.|....:
Mouse  1588 AAEVEKQLRSLMESGANRLQEEVLIQEWFTLVNKKNALIRRQDQLQLLIEE-QDLERRFELLSRE 1651

  Fly   469 LAAHQDRVEQIAAIAQE-LNTLEYHDCVS-VNARCQRICDQWDRLGALTQRRRTALDEAERI 528
            |.|.....|....:||: ...|...:.|| ||.|.:.:.|       |.|:.|.||:|.||:
Mouse  1652 LRAMLAIEEWQKTVAQQHREQLLLEELVSLVNQRDELVRD-------LDQKERIALEEDERL 1706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_477485.1	CH_ACTN_rpt1	31..135	CDD:409063
		CH_ACTN_rpt2	139..252	CDD:409065	41/104 (39%)
		SPEC	302..525	CDD:238103	58/341 (17%)
		SPEC	420..647	CDD:238103	30/113 (27%)
		SPEC	538..760	CDD:238103
		EFh	775..842	CDD:238008
		EFhand_Ca_insen	847..913	CDD:430177
Ehbp1l1	XP_030106561.1	NT-C2	12..164	CDD:463058
		PHA03307	185..>538	CDD:223039
		CH_EHBP1L1	1223..1327	CDD:409104	43/105 (41%)
		bMERB_dom	1573..1706	CDD:463467	33/140 (24%)