DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and actn3

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001135513.1	Gene:	actn3 / 100216053	XenbaseID:	XB-GENE-920242	Length:	896	Species:	Xenopus tropicalis

Alignment Length:	913	Identity:	632/913 - (69%)
Similarity:	754/913 - (82%)	Gaps:	28/913 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NGLSMEYGDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLM 69
            |..:|...| ||.|||:|:|:.||||||||||:||||||||||||||||.|:|||||||||||||
Frog    12 NSYNMTEED-YMVQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLM 75

  Fly    70 LLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTII 134
            |||||||||.|||||:|||||||||||||||||||||||.|||||||||||||||||||||||||
Frog    76 LLLEVISGERLPKPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTII 140

  Fly   135 LRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKL 199
            ||||||||||||.:||||||||||||||||:||||||||:|:|||||.||||||||||||||:||
Frog   141 LRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHISWKDGLALCALIHRHRPDLIDYSKL 205

  Fly   200 SKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHV 264
            .||:|:.||||||||||||||||:|||.:|::|||||||:||||||||:||||.||:|
Frog   206 RKDDPIGNLNTAFDVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQ------- 263

  Fly   265 PEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADN 329
                           ||||||||||||.||||||:||||||:|||:||||||||:|||.:|..:.
Frog   264 ---------------AETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTIPWLENRTPEK 313

  Fly   330 SLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWK 394
            ::..:|||||::|.|||.||||||::|.:||.||||||||||||||||::|:|||.||||:|:||
Frog   314 NMGAMQKKLEDFRDYRRVHKPPRVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDIANAWK 378

  Fly   395 GLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALK 459
            |||..||.:|||||.|..|||||||||:|||.||..||.|||||||:|..:|:....|.|::||.
Frog   379 GLEQVEKGYEEWLLLEIRRLERLEHLAEKFKQKASLHESWTRGKEELLTQRDYESASLMEIRALV 443

  Fly   460 KKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDE 524
            :|||||||||||||||||||||||||||.|:|||..|||:|||.||||||.||.|||:||.||:.
Frog   444 RKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAASVNSRCQAICDQWDNLGTLTQKRRDALER 508

  Fly   525 AERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKE 589
            .|::||.||.|:|||||||||||||:||..|||.||||||::||||.||.||:||||||.|||||
Frog   509 VEKLLETIDQLYLEFAKRAAPFNNWMDGAVEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADKE 573

  Fly   590 FNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNE 654
            ...|:.:..|::.|.:.:.|.....||||.||..|::.||..|:||||.|||||..||.:||.||
Frog   574 KMSILGIQAEIQKIAQTYGIKLSGINPYTNLTHLDISNKWETVKQLVPHRDQTLQEELARQQANE 638

  Fly   655 MLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQA 719
            .||||||.:||::||||:.:|:.:..|.:.:..|||||::.||:|||.:.:||.||::||..||.
Frog   639 RLRRQFAAQANVIGPWIQSKMEEIGRISVDISASLEDQMNHLKQYEQNIISYKSNIDKLEGDHQL 703

  Fly   720 VQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFD 784
            :|||:||:|::|||:||.:|||||||||:|.|.||||||||||||:|||||||:||||:||||||
Frog   704 IQESLIFDNKHTNYSMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFD 768

  Fly   785 KNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAVVDPNNTGYVHFDAFLDFMTRESTDTD 849
            :.|.|.:.|::|::||:|:||.:     |:::|.||:.:|||||||.|.|.||:||||||:.:||
Frog   769 RKRNGMMDPDDFRACLISMGYDL-----GEVEFARIMTLVDPNNTGVVTFQAFIDFMTRETAETD 828

  Fly   850 TAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFSTALYGE 914
            |||||:.||:|||:||.||..:||||||||:||||||.||..|.|.:.:.|||||||||:|||||
Frog   829 TAEQVMASFKILASDKSYITIEELRRELPPEQAEYCITRMTKYTGADAISGALDYMSFSSALYGE 893

  Fly   915 TDL 917
            :||
Frog   894 SDL 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	97/103 (94%)
		CH_ACTN_rpt2	139..252	CDD:409065	94/112 (84%)
		SPEC	302..525	CDD:238103	156/222 (70%)
		SPEC	420..647	CDD:238103	146/226 (65%)
		SPEC	538..760	CDD:238103	131/221 (59%)
		EFh	775..842	CDD:238008	35/66 (53%)
		EFhand_Ca_insen	847..913	CDD:400872	45/65 (69%)
actn3	NP_001135513.1	SAC6	38..>378	CDD:227401	282/361 (78%)
		SPEC	404..631	CDD:238103	146/226 (65%)
		Spectrin	639..741	CDD:334073	57/101 (56%)
		FRQ1	752..862	CDD:227455	70/114 (61%)
		EFhand_Ca_insen	826..892	CDD:312305	45/65 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3005
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H862
Inparanoid	1	1.050	1299	1.000	Inparanoid score	I158
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	1	1.000	-	-		FOG0000815
OrthoInspector	1	1.000	-	-		otm49049
Panther	1	1.100	-	-	LDO	PTHR11915
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X512
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160