DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment usp and NR1D2

DIOPT Version :10

Sequence 1:NP_476781.1 Gene:usp / 31165 FlyBaseID:FBgn0003964 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_005117.3 Gene:NR1D2 / 9975 HGNCID:7963 Length:579 Species:Homo sapiens


Alignment Length:625 Identity:145/625 - (23%)
Similarity:217/625 - (34%) Gaps:233/625 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 SNNSSFSPKA----ESPVPFMQAMSMVHVLPGSNSASSNNNSAG---------------DAQMAQ 74
            |::|:.||.:    .|...|..:.|.|...|.|:::.:|.|...               |..|..
Human    14 SSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDLANIEGILKNDRIDCSMKT 78

  Fly    75 APNSAGGSAAAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTY- 138
            :.:||.|     :.:.:......||...||.:|||.|||.||||::||||||||:|::::::.| 
Human    79 SKSSAPG-----MTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYK 138

  Fly   139 ACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAV------QEERQR------GARNAAGRLSA 191
            .|.:|.||.|.:..|||||.||::|||:.||.|:||      :.|:||      .|.........
Human   139 KCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQF 203

  Fly   192 SGG--------------------------------GSSGPGSVGGSSSQGGGGGGGVSGGMGSGN 224
            ||.                                .||.|.|...:..:        ..||.:..
Human   204 SGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEE--------VIGMVTRA 260

  Fly   225 GSDDFMTNSVSRDFSIERIIEAEQRAE-------------TQCGDRALTFLRVGPYSTVQPDYKG 276
            ..|.||.|...::.|.|.:  ..||.|             ..||:...:..   |.|..|....|
Human   261 HKDTFMYNQEQQENSAESM--QPQRGERIPKNMEQYNLNHDHCGNGLSSHF---PCSESQQHLNG 320

  Fly   277 AVS-----------ALC---------------------------QVVNKQLF------------- 290
            ...           |:|                           |..||..:             
Human   321 QFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCNTGGRMHLVCP 385

  Fly   291 -----------------------------QMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANV 326
                                         ::||:|:.:|.|..:...|||.||||...|:|:  |
Human   386 MSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLM--V 448

  Fly   327 AWCSI---------------VSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNS 376
            .:.|:               .|:||..:.|.|.                    .||..|      
Human   449 RFASLFDAKERTVTFLSGKKYSVDDLHSMGAGD--------------------LLNSMF------ 487

  Fly   377 AIKAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLD 441
                           |.|.|:..|.|...|:|...|::|.:.|..||::...:|..:|.:...|.
Human   488 ---------------EFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALR 537

  Fly   442 EHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRI 481
            ......||.:...|.:|||:||.|||::....:.|..|::
Human   538 TLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uspNP_476781.1 NR_DBD_RXR 102..178 CDD:143514 42/82 (51%)
NR_LBD_RXR_like 237..480 CDD:132741 67/350 (19%)
NR1D2NP_005117.3 Modulating 1..99 18/89 (20%)
Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250|UniProtKB:Q60674 1..60 12/45 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 13..61 12/46 (26%)
NR_DBD_REV_ERB 98..186 CDD:143540 44/87 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 222..250 4/27 (15%)
NR_LBD_REV_ERB 389..577 CDD:132738 52/230 (23%)
Interaction with ZNHIT1. /evidence=ECO:0000269|PubMed:17892483 397..579 52/224 (23%)

Return to query results.
Submit another query.