DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment usp and Rxrg

DIOPT Version :9

Sequence 1:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_038947050.1	Gene:	Rxrg / 83574	RGDID:	620046	Length:	464	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	200/484 - (41%)
Similarity:	258/484 - (53%)	Gaps:	120/484 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VKPDISQLNDSNNSSFSPKAESPVPFMQAMSMVHVLPGSNSASSNNNSAGDAQMAQAPNSAGGSA 83
            |.|..||||..|:.|.|...: |:|         .|||..:
  Rat    93 VVPPSSQLNVVNSVSSSEDIK-PLP---------GLPGIGN------------------------ 123

  Fly    84 AAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCII 148
                 ..||...|.|..||:|:|||||:||||||||||||||||||||:||||.|.||:|::|:|
  Rat   124 -----MNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLI 183

  Fly   149 DKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGG 213
            |||||||||||||||||..|||||||||||||....|......:..|
  Rat   184 DKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECASTG------------------ 230

  Fly   214 GGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQC---GDRALTFLRVGPYSTVQPDYK 275
                                 ..|..:|||:|||...|.:.   ||.::      ..||..|
  Rat   231 ---------------------HEDMPVERILEAELAVEPKTESYGDMSV------ESSTNDP--- 265

  Fly   276 GAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAG 340
              |:.:|...:||||.:||:|:.:|||:.:.|:||||||:|.|.|||||
  Rat   266 --VTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIA---------------- 312

  Fly   341 GGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFD-RILSELSVKMKRLNLDR 404
                      ||..||..:| ..:.|......||:||..|||.:||| |:|:||..|||.:.:|:
  Rat   313 ----------SFSHRSVSVQ-DGILLATGLHVHRSSAHSAGVGSIFDSRVLTELVSKMKDMRMDK 366

  Fly   405 RELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSIS 469
            .||.||:||:|:|||.:|:.:.:|:|..||||||.|:.:.:.::|...||||:|||||||||||.
  Rat   367 SELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIG 431

  Fly   470 LKCQDHLFLFRITSDRPLEELFLEQLEAP 498
            |||.:|||.|::..|.|::...:|.||.|
  Rat   432 LKCLEHLFFFKLIGDTPIDTFLMEMLETP 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	63/75 (84%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	105/246 (43%)
Rxrg	XP_038947050.1	Nuc_recep-AF1	25..133	CDD:403126	17/78 (22%)
		NR_DBD_RXR	137..213	CDD:143514	63/75 (84%)
		NR_LBD_RXR_like	233..442	CDD:132741	105/246 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338083
Domainoid	1	1.000	189	1.000	Domainoid score	I3200
eggNOG	1	0.900	-	-		E33208_3BA8J
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2108
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D389616at33208
OrthoFinder	1	1.000	-	-		FOG0001500
OrthoInspector	1	1.000	-	-		otm46466
orthoMCL	1	0.900	-	-		OOG6_103349
Panther	1	1.100	-	-	O	PTHR24083
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760