DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment usp and rxrab

DIOPT Version :9

Sequence 1:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_009300230.1	Gene:	rxrab / 793011	ZFINID:	ZDB-GENE-990415-243	Length:	494	Species:	Danio rerio

Alignment Length:	493	Identity:	204/493 - (41%)
Similarity:	279/493 - (56%)	Gaps:	97/493 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SQLNDSNNSSFSPKAESPVPFMQAMSMVHVLPGSNSASSNNNSAGDAQMAQAPNSAGGSAAAAVQ 88
            |.::.|.....||....|.||....|.:    |.:|.|..::::...:.:.:|..:....|.:..
Zfish    77 STMSSSPGQLHSPINGLPSPFSTLSSPM----GHSSMSGPSSTSMSFRPSLSPQLSSPMNAVSSS 137

  Fly    89 QQYPPNHPLSG----------------SKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLT 137
            :...|...|:|                :||:|:|||||:||||||||||||||||||||||||||
Zfish   138 EDIKPPLGLNGVMKVPAQPIGTLSLSLTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLT 202

  Fly   138 YACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSV 202
            |.||:|::|:||||||||||||||||||..|||||||||||||    |..|..|..||.:
Zfish   203 YTCRDNKDCMIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQR----AKERSEAEFGGCA----- 258

  Fly   203 GGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFL--RVG 265
                                            :.|..:|:|:|||...|    .:..|::  .:.
Zfish   259 --------------------------------NEDMPVEKILEAELAVE----PKTETYVEANLS 287

  Fly   266 PYSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCS 330
            |.:....|   .|:.:||..:||||.:||:|:.:|||:.:|||||||||:|.|.|||||:.:..|
Zfish   288 PSANSPND---PVTNICQAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRS 349

  Fly   331 IVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSV 395
            | ::.||                          :.|......|||||..|||.|||||:|:||..
Zfish   350 I-AVKDG--------------------------ILLATGLHVHRNSAHTAGVGAIFDRVLTELVS 387

  Fly   396 KMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLL 460
            ||:.:.:|:.||.||:||:|:|||.:|:.:.:|:|..||:|||.|:.:|:.::|...||||:|||
Zfish   388 KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPSEVEALRERVYASLEAYCKHKYPDQPGRFAKLLL 452

  Fly   461 RLPALRSISLKCQDHLFLFRITSDRPLEELFLEQLEAP 498
            ||||||||.|||.:|||.|::..|.|::...:|.||||
Zfish   453 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	65/75 (87%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	105/244 (43%)
rxrab	XP_009300230.1	Nuc_recep-AF1	57..159	CDD:288658	16/85 (19%)
		NR_DBD_RXR	167..243	CDD:143514	65/75 (87%)
		NR_LBD_RXR_like	261..472	CDD:132741	105/244 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577465
Domainoid	1	1.000	188	1.000	Domainoid score	I3237
eggNOG	1	0.900	-	-		E33208_3BA8J
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	365	1.000	Inparanoid score	I2124
OMA	1	1.010	-	-		QHG45637
OrthoDB	1	1.010	-	-		D389616at33208
OrthoFinder	1	1.000	-	-		FOG0001500
OrthoInspector	1	1.000	-	-		otm25754
orthoMCL	1	0.900	-	-		OOG6_103349
Panther	1	1.100	-	-	O	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770