DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment usp and rxrg

DIOPT Version :9

Sequence 1:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_004913829.2	Gene:	rxrg / 779621	XenbaseID:	XB-GENE-478493	Length:	535	Species:	Xenopus tropicalis

Alignment Length:	483	Identity:	203/483 - (42%)
Similarity:	267/483 - (55%)	Gaps:	94/483 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 NSSFSPKAESPVPFMQAMSMV--HVL--------PGSNSASSN--NNSAGDAQMAQAPNSAGGSA 83
            ||..||......|:....|.:  |.|        ||..|...|  ||.:....:...|..:  :.
Frog   128 NSLCSPGNNIGPPYRVIASSMGPHSLPSPTILNFPGHESPPFNLMNNISCSEDIKPPPGLS--NL 190

  Fly    84 AAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCII 148
            .:.....|..|.|.:.:||:|:|||||:||||||||||||||||||||:||||.|.||:.::|:|
Frog   191 GSPCMNNYSCNSPGALTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLVYTCRDTKDCLI 255

  Fly   149 DKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGG 213
            |||||||||||||||||..|||||||||||||....
Frog   256 DKRQRNRCQYCRYQKCLAMGMKREAVQEERQRSREK----------------------------- 291

  Fly   214 GGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQC---GDRALTFLRVGPYSTVQPDYK 275
                      :.::...|:|.|.:..:|||:|||...|.:.   ||..|      |.||..|
Frog   292 ----------SDTEAESTSSTSEEMPVERILEAELAVEPKIEAFGDAGL------PNSTNDP--- 337

  Fly   276 GAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAG 340
              |:.:|...:||||.:||:|:.:|||:.:||:||||||:|.|.|||||
Frog   338 --VTNICHAADKQLFTLVEWAKRIPHFSDLPLEDQVILLRAGWNELLIA---------------- 384

  Fly   341 GGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNLDRR 405
                      ||..||..:| ..:.|......||:||..|||.:||||:|:||..|||.:.:|:.
Frog   385 ----------SFSHRSVSVQ-DGILLATGLHVHRSSAHNAGVGSIFDRVLTELVSKMKDMEMDKS 438

  Fly   406 ELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISL 470
            ||.||:||:|:|||.:|:.:.||:|..||||||.|:.:.:.::|...||||:|||||||||||.|
Frog   439 ELGCLRAIVLFNPDAKGLSNAAEVEALREKVYATLESYTKQKYPEQPGRFAKLLLRLPALRSIGL 503

  Fly   471 KCQDHLFLFRITSDRPLEELFLEQLEAP 498
            ||.:|||.|::..|.|::...:|.||.|
Frog   504 KCLEHLFFFKLIGDTPIDTFLMEMLETP 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	62/75 (83%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	108/245 (44%)
rxrg	XP_004913829.2	Nuc_recep-AF1	99..205	CDD:371746	18/78 (23%)
		NR_DBD_RXR	209..285	CDD:143514	62/75 (83%)
		NR_LBD_RXR_like	305..513	CDD:132741	108/245 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3247
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2229
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D389616at33208
OrthoFinder	1	1.000	-	-		FOG0001500
OrthoInspector	1	1.000	-	-		otm49544
Panther	1	1.100	-	-	O	PTHR24083
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160