Protein Alignment usp and NR2C2

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: XP_011532360.1
• Gene: NR2C2 / 7182
• HGNCID: 7972
• Length: 648
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 141/501 - (28%)
• Similarity: 199/501 - (39%)
• Gaps: 182/501 - (36%)

  Fly   104 CSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCG 168
            |.:|||:|||:|||..|||||||||||:|||:|||:||.|::|||:|..|||||:||.:|||..|
Human   169 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMG 233

  Fly   169 MKREAVQEER-----QR----------------------------------GAR----------- 183
            ||.|:||.||     ||                                  |||
Human   234 MKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLV 298

  Fly   184 -------------------------NAAGRL------------SASGG----------------- 194
                                     .|.|.|            |.:.|
Human   299 NIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQPEDQSASEITR 363

  Fly   195 -------------GSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEA 246
                         .||.|....|..:.|||.                  .:.:|||.|.. |||.
Human   364 AFDTLAKALNTTDSSSSPSLADGIDTSGGGS------------------IHVISRDQSTP-IIEV 409

  Fly   247 EQRAETQCGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQV 311
            |   .....|..:||....|  :..|:|.. |..:|:..::.||..:.:||.:|.|..:..|...
Human   410 E---GPLLSDTHVTFKLTMP--SPMPEYLN-VHYICESASRLLFLSMHWARSIPAFQALGQDCNT 468

  Fly   312 ILLKAAWIELLIANVAWCS-IVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRN 375
            .|::|.|.||....:|.|: ::||                            ...|....::.:|
Human   469 SLVRACWNELFTLGLAQCAQVMSL----------------------------STILAAIVNHLQN 505

  Fly   376 SAIKAGVSAIFDRI---------LSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEM 431
            |..:..:|.  |||         |.|....|.:|::|..|.:.||||:|::||..|:.|.::||.
Human   506 SIQEDKLSG--DRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEK 568

  Fly   432 CREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLF 477
            .:||....|.::.:..:..|..|.|::|:||||||.:|....:.||
Human   569 FQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELF 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	50/73 (68%)
		NR_LBD_RXR_like	237..480	CDD:132741	70/251 (28%)
NR2C2	XP_011532360.1	NR_DBD_TR2_like	164..250	CDD:143525	52/80 (65%)
		NR_LBD_TR2_like	413..634	CDD:132750	64/235 (27%)