DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment usp and RXRA

DIOPT Version :9

Sequence 1:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_002948.1	Gene:	RXRA / 6256	HGNCID:	10477	Length:	462	Species:	Homo sapiens

Alignment Length:	486	Identity:	210/486 - (43%)
Similarity:	276/486 - (56%)	Gaps:	88/486 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ISQLNDSNNSSFSPKA--ESPV-PFMQAMSMVHVL---PGSNSASSNNNSAGDAQMAQAPNSAGG 81
            ||.|:...|....|.:  .||: |...::.....|   .||...||..|....::..:.|....|
Human    51 ISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNG 115

  Fly    82 SAAAAVQQQYPPNHP----LSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRE 142
            ....       |.||    .|.:||:|:|||||:|||||||||||||||||||||||||||.||:
Human   116 VLKV-------PAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRD 173

  Fly   143 NRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSS 207
            |::|:||||||||||||||||||..||||||||||||||.
Human   174 NKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGK------------------------- 213

  Fly   208 QGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGPYSTVQP 272
                          ..|.::...|:|.:.|..:|||:|||...|.:........:.:.|.|...|
Human   214 --------------DRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDP 264

  Fly   273 DYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDG 337
                 |:.:||..:||||.:||:|:.:|||:::|||||||||:|.|.|||||:.:..|| ::.||
Human   265 -----VTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI-AVKDG 323

  Fly   338 GAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNL 402
                                      :.|......|||||..|||.|||||:|:||..||:.:.:
Human   324 --------------------------ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQM 362

  Fly   403 DRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRS 467
            |:.||.||:||:|:|||.:|:.:.||:|..||||||.|:.:|:.::|...||||:||||||||||
Human   363 DKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRS 427

  Fly   468 ISLKCQDHLFLFRITSDRPLEELFLEQLEAP 498
            |.|||.:|||.|::..|.|::...:|.||||
Human   428 IGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	65/75 (87%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	108/242 (45%)
RXRA	NP_002948.1	Modulating. /evidence=ECO:0000250	1..134		21/89 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107		14/55 (25%)
		Nuc_recep-AF1	17..126	CDD:403126	19/81 (23%)
		NR_DBD_RXR	133..209	CDD:143514	65/75 (87%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:12145331	160..165		4/4 (100%)
		Hinge	201..224		13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..228		10/60 (17%)
		NR_LBD_RXR_like	229..440	CDD:132741	108/242 (45%)
		Required for nuclear export. /evidence=ECO:0000269\|PubMed:15509776	348..368		8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144373
Domainoid	1	1.000	189	1.000	Domainoid score	I3290
eggNOG	1	0.900	-	-		E33208_3BA8J
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2220
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2165
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45637
OrthoDB	1	1.010	-	-		D389616at33208
OrthoFinder	1	1.000	-	-		FOG0001500
OrthoInspector	1	1.000	-	-		otm42314
orthoMCL	1	0.900	-	-		OOG6_103349
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770