Protein Alignment usp and nr1d4b

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001272462.1
• Gene: nr1d4b / 571948
• ZFINID: ZDB-GENE-080403-6
• Length: 576
• Species: Danio rerio
• Alignment Length: 599
• Identity: 136/599 - (22%)
• Similarity: 223/599 - (37%)
• Gaps: 185/599 - (30%)

  Fly    30 NNSSFSPKAESPVPFMQAMSMVHVLPGSNSAS---------------SNNNSAGDAQMAQAPNSA 79
            :..|.||...||....|..|     |.|..:|               |:..:.|:..:.|.|..:
Zfish    14 STGSASPSPGSPSSGYQTQS-----PSSQPSSPEEVSFTGLGALKKHSSGGNGGNKLVFQFPEVS 73

  Fly    80 GGSAAAAV--------QQQYPPNHPLSGSKH---------------LCSICGDRASGKHYGVYSC 121
            ..:...||        |..|  :||:.|.:.               ||.:|||.|||.||||::|
Zfish    74 SANTVNAVTPTVTSSGQNSY--SHPMVGRRPTGFTGTFTKTGGMVLLCKVCGDIASGFHYGVHAC 136

  Fly   122 EGCKGFFKRTVRKDLTY-ACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAV------QEERQ 179
            |||||||:|::::::.| .|.:|.||:|.:..|||||:||::|||:.||.|:||      :.|:|
Zfish   137 EGCKGFFRRSIQQNIHYKMCVKNENCLIMRMNRNRCQHCRFKKCLSVGMSRDAVRFGRIPKREKQ 201

  Fly   180 R------GARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGG-GV--------------------- 216
            |      ...|:....::...|.:.|.....|...|..... ||
Zfish   202 RLLDEMQSYMNSLNESASMDIGCTTPTETPSSPEDGQSEESIGVISQAYRNIFVNGEKLQVKVDQ 266

  Fly   217 SGGMGSGNGSDDFMTNSVSRDFSIER----IIEAEQR---------AETQC-------------- 254
            ...:.:.|....|..:.:.....::.    .|.|::.         |:::|
Zfish   267 ENNVNNNNNPSSFRHHPMQESGYVQSHPQPNISAQEHSVHSTTSCLAQSRCPVANQNNKPTSQVL 331

  Fly   255 -------------------------------------------GDRALTF-LRVGPYSTVQPDYK 275
                                                       |.:.|.. |...|.|:.....:
Zfish   332 DNGHYNFPQSSSPSQGTTPTQSYPTKHNSYSTQTQSCPWRLSPGAKVLACPLNACPVSSASHSSQ 396

  Fly   276 GAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAG 340
            ....:..|.....:.::||:|:.:|.|..:...|||:||||...::|:  |.:||:.:..:...
Zfish   397 QVWESFSQCFTPAVKEVVEFAKSIPGFQALSQHDQVMLLKAGTFQVLM--VRFCSLFNAKERTV- 458

  Fly   341 GGGGGLGHDGSFERRSPGLQPQQLFLN-QSF--SYHRNSAIKAGVSAIFDRILSELSVKMKRLNL 402
                                   .||| |::  ||.|    ..|:..:.|.:. |.|.|:..:.|
Zfish   459 -----------------------TFLNGQTYPLSYLR----VLGMGNLLDAMF-EFSEKLGSMGL 495

  Fly   403 DRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRS 467
            :..|::...|::|.:.|..||.....:|..:|.:...|........|.|...|.:|.||||.||:
Zfish   496 EADEMALFMAVVLVSADRSGISDMGAVEQLQEDLIGALRALITRRKPEDSSLFPKLPLRLPDLRT 560

  Fly   468 ISLKCQDHLFLFRI 481
            ::.:..:.|..|.|
Zfish   561 LNNQHSEKLLAFHI 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	42/97 (43%)
		NR_LBD_RXR_like	237..480	CDD:132741	59/316 (19%)
nr1d4b	NP_001272462.1	NR_DBD_REV_ERB	115..202	CDD:143540	43/86 (50%)
		NR_LBD	386..574	CDD:472173	53/218 (24%)