Protein Alignment usp and Nr2c2

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: XP_038964194.1
• Gene: Nr2c2 / 50659
• RGDID: 3201
• Length: 629
• Species: Rattus norvegicus
• Alignment Length: 606
• Identity: 154/606 - (25%)
• Similarity: 233/606 - (38%)
• Gaps: 204/606 - (33%)

  Fly    35 SPKAESPVPFMQAMSMVHVL--PGSNSASSNNNSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHP- 96
            ||...||.|.:|.:|....:  |......::..:....|:..|.:::|.|     :||:....|
  Rat    31 SPGMTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSS-----KQQFILTSPD 90

  Fly    97 -------------LSGSKHL---------------------------------------CSICGD 109
                         .|.:|.|                                       |.:|||
  Rat    91 GAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGD 155

  Fly   110 RASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAV 174
            :|||:|||..|||||||||||:|||:|||:||.:::|||:|..|||||:||.:|||..|||.|:|
  Rat   156 KASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESV 220

  Fly   175 QEERQ-------------------------RGARNAAGRLSASGGGSSGPGSVG----------- 203
            |.||:                         |....|.....|...||...|.:.
  Rat   221 QSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGSRQTGLLDPGMLVNIQQPL 285

  Fly   204 --------------GSSSQGGGGG--------GGVSGGMGSGNGS----DDFMTNSVSRDFS--- 239
                          ..:|||..|.        ..:|..:.:|:.|    :|...:.::|.|.
  Rat   286 IREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDASEMQPEDQSASEITRAFDTLA 350

  Fly   240 ----------------------------IER-----IIEAEQRAETQCGDRALTFLRVGPYSTVQ 271
                                        |.|     |||.|   .....|..:||....|  :..
  Rat   351 KALNTTDSASPPSLADGIDASGGGSIHVISRDQSTPIIEVE---GPLLSDTHVTFKLTMP--SPM 410

  Fly   272 PDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCS-IVSLD 335
            |:|.. |..:|:..::.||..:.:||.:|.|..:..|....|::|.|.||....:|.|: ::||
  Rat   411 PEYLN-VHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSL- 473

  Fly   336 DGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRI---------LS 391
                                       ...|....::.:||..:..:|.  |||         |.
  Rat   474 ---------------------------STILAAIVNHLQNSIQEDKLSG--DRIKQVMEHIWKLQ 509

  Fly   392 ELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFA 456
            |....|.:|::|..|.:.||||:|::||..|:...::||..:||....|.::.:..:..|..|.|
  Rat   510 EFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDYVQKTYSEDTYRLA 574

  Fly   457 QLLLRLPALRSISLKCQDHLF 477
            ::|:||||||.:|....:.||
  Rat   575 RILVRLPALRLMSSNITEELF 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	50/114 (44%)
		NR_LBD_RXR_like	237..480	CDD:132741	70/287 (24%)
Nr2c2	XP_038964194.1	NR_DBD_TR2_like	145..231	CDD:143525	51/85 (60%)
		NR_LBD_TR2_like	394..615	CDD:132750	63/235 (27%)