DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment usp and Hnf4

DIOPT Version :9

Sequence 1:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	147/544 - (27%)
Similarity:	235/544 - (43%)	Gaps:	158/544 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DSNNSSFSPKAESPVPFMQAMSMVHVLP------------------------GSNSASSN----- 63
            ||:.|..:...||....|.|.::....|                        .||.:|.|
  Fly    50 DSSASRTASSDESESHIMHADALASAYPAASQPHSPIGLALSPNGGGLGLSNSSNQSSENFALCN 114

  Fly    64 -NNSAGDAQMAQAPNSAGGSAAAAV---QQQYPPNHPLSG-------------------SKHLCS 105
             |.:||.|        .||||::..   ...:.||:.|||                   |..:|:
  Fly   115 GNGNAGSA--------GGGSASSGSNNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCA 171

  Fly   106 ICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMK 170
            ||||||:|||||..||:||||||:|:|||:..|.||..|||::||.:||:|:|||.:||...|||
  Fly   172 ICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMK 236

  Fly   171 REAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVS 235
            :||||.||.        |:|.....:..|                     ..|||
  Fly   237 KEAVQNERD--------RISCRRTSNDDP---------------------DPGNG---------- 262

  Fly   236 RDFSIERIIEAEQRA-ETQCGDRALTFLRVGPYSTVQPDYK--------GAVSALCQVVNKQLFQ 291
              .|:..:::||..: :::.|            :.::|:..        .:::.:|:.:.:||..
  Fly   263 --LSVISLVKAENESRQSKAG------------AAMEPNINEDLSNKQFASINDVCESMKQQLLT 313

  Fly   292 MVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRS 356
            :||:|:.:|.|.::.|||||.||:|...|.|:..::                          |||
  Fly   314 LVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLS--------------------------RRS 352

  Fly   357 PGLQPQQLFLNQS-FSYHRNSAI---KAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYN 417
            ..|:...|..|.. .:.|....:   ...:|.|..||:.||...||.:.:|..|.:|:||::.::
  Fly   353 MHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFD 417

  Fly   418 PDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRIT 482
            |:.:|:.....|:..|.::...|:::.........|||.::||.||.|:||:.:..:.:...:|.
  Fly   418 PNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIF 482

  Fly   483 S----DRPLEELFL--EQLEAPPP 500
            .    |..|:|:.|  |..:.|.|
  Fly   483 GVAHIDSLLQEMLLGGELADNPLP 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	47/75 (63%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	58/255 (23%)
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	48/74 (65%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	61/267 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444773
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D389616at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950