DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment usp and svp

DIOPT Version :9

Sequence 1:NP_001259168.1 Gene:usp / 31165 FlyBaseID:FBgn0003964 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_001369011.1 Gene:svp / 41491 FlyBaseID:FBgn0003651 Length:826 Species:Drosophila melanogaster


Alignment Length:520 Identity:155/520 - (29%)
Similarity:235/520 - (45%) Gaps:103/520 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 ASFRLSHIKEEVK-PDISQLNDSNNSSFSPKAESPVPFMQAMSM--VHVLPGSNSASSNNNSAGD 69
            ||.:.:.||:::. |.::|....::........|.:|.....|.  .|...||.|.|..|...|.
  Fly    81 ASQQSAVIKQDLSCPSLNQAGSGHHPGIKEDLSSSLPSANGGSAGGHHSGSGSGSGSGVNPGHGS 145

  Fly    70 --------------AQMAQAPNSAGGSAAAAVQQQYPPNHPLSGSK------HLCSICGDRASGK 114
                          ..:...|...|.:..::...........|||:      ..|.:|||::|||
  Fly   146 DMLPLIKGHGQDMLTSIKGQPTGCGSTTPSSQANSSHSQSSNSGSQIDSKQNIECVVCGDKSSGK 210

  Fly   115 HYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQ 179
            |||.::|||||.||||:||::|||:||.:|||.||:..||:|||||.:|||..||:|||||.   
  Fly   211 HYGQFTCEGCKSFFKRSVRRNLTYSCRGSRNCPIDQHHRNQCQYCRLKKCLKMGMRREAVQR--- 272

  Fly   180 RGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERII 244
                   ||:..:..|.:|   :.|......|...|::|..|     ..::::.:|         
  Fly   273 -------GRVPPTQPGLAG---MHGQYQIANGDPMGIAGFNG-----HSYLSSYIS--------- 313

  Fly   245 EAEQRAETQCGDRALTFLRVGPYST------VQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFA 303
                           ..||..||.|      :||:....:..:|::..:.||..||:|:.:|.|.
  Fly   314 ---------------LLLRAEPYPTSRYGQCMQPNNIMGIDNICELAARLLFSAVEWAKNIPFFP 363

  Fly   304 QVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLF-LN 367
            ::.:.|||.||:..|.||.:.|.:.||:                             |..:. |.
  Fly   364 ELQVTDQVALLRLVWSELFVLNASQCSM-----------------------------PLHVAPLL 399

  Fly   368 QSFSYHRNSAIKAGVSAIFD--RILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIE 430
            .:...|.:......|.|..|  ||..|...|:|.|::|..|.||||||:|:..|..|:.....||
  Fly   400 AAAGLHASPMAADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTTDACGLSDVTHIE 464

  Fly   431 MCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQL 495
            ..:||....|:|:||.::|....||.:||||||:||::|.:..:.||..|:....|:|.|..:.|
  Fly   465 SLQEKSQCALEEYCRTQYPNQPTRFGKLLLRLPSLRTVSSQVIEQLFFVRLVGKTPIETLIRDML 529

  Fly   496  495
              Fly   530  529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uspNP_001259168.1 NR_DBD_RXR 102..178 CDD:143514 48/75 (64%)
NR_LBD_RXR_like 237..480 CDD:132741 71/251 (28%)
svpNP_001369011.1 NR_DBD_COUP_TF 200..272 CDD:143516 47/71 (66%)
NR_LBD_COUP-TF 307..542 CDD:132746 77/276 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24083
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X118
33.010

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