DRSC/TRiP Functional Genomics Resources

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Protein Alignment usp and HNF4A

DIOPT Version :10

Sequence 1:NP_476781.1 Gene:usp / 31165 FlyBaseID:FBgn0003964 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_000448.3 Gene:HNF4A / 3172 HGNCID:5024 Length:474 Species:Homo sapiens


Alignment Length:442 Identity:134/442 - (30%)
Similarity:203/442 - (45%) Gaps:104/442 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 NNNSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGF 127
            |:.|..:.....||||.|.||                   ||:||||||:|||||..||:|||||
Human    38 NDTSPSEGTNLNAPNSLGVSA-------------------LCAICGDRATGKHYGASSCDGCKGF 83

  Fly   128 FKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSAS 192
            |:|:|||:..|:||.:|.|::||.:||:|:|||.:||...|||:||||.||.|     .....:|
Human    84 FRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDR-----ISTRRSS 143

  Fly   193 GGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDR 257
            ...||.|                                       ||..:::||..:      |
Human   144 YEDSSLP---------------------------------------SINALLQAEVLS------R 163

  Fly   258 ALTFLRVGPYSTVQPDYK----GAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAW 318
            .:|    .|.|.:..|.:    .:::.:|:.:.:||..:||:|:.:|.|.::||||||.||:|..
Human   164 QIT----SPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHA 224

  Fly   319 IELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVS 383
            .|.|:......|:|..|                           .|.|...:...|:....|.:|
Human   225 GEHLLLGATKRSMVFKD---------------------------VLLLGNDYIVPRHCPELAEMS 262

  Fly   384 AIFDRILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEH 448
            .:..|||.||.:..:.|.:|..|.:.|||||.::||.:|:....:|:..|.:|...|:::.....
Human   263 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQ 327

  Fly   449 PGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQLEAPPP 500
            ....|||.:|||.||.|:||:.:..:.:...::.....::.|..|.|....|
Human   328 YDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSP 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uspNP_476781.1 NR_DBD_RXR 102..178 CDD:143514 47/75 (63%)
NR_LBD_RXR_like 237..480 CDD:132741 67/246 (27%)
HNF4ANP_000448.3 NR_DBD_HNF4A 60..135 CDD:143518 47/74 (64%)
NR_LBD_HNF4_like 151..373 CDD:132729 68/258 (26%)
9aaTAD. /evidence=ECO:0000269|PubMed:30468856 368..376 3/7 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..447
Blue background indicates that the domain is not in the aligned region.

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