DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment usp and rxrba

DIOPT Version :9

Sequence 1:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_009292297.1	Gene:	rxrba / 30530	ZFINID:	ZDB-GENE-980526-436	Length:	480	Species:	Danio rerio

Alignment Length:	540	Identity:	206/540 - (38%)
Similarity:	280/540 - (51%)	Gaps:	135/540 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SQLNDSNNSSFSPKAESPVPFMQAMSMVHVLPGSNSASSN------------NNSAGDAQMAQAP 76
            |:..||::.|..|..:...|...:.:.:..||...||.::            ::|.|...:...|
Zfish     7 SRSPDSSSVSSPPSGQRSPPLAPSAAAMTSLPPITSAVNSPISSMGSPFSVISSSLGSPCLPGTP 71

  Fly    77 NSAGGSAAAAVQQQYPPN------------HPLSGS-----------------------KHLCSI 106
            :...|..::.....:|.|            |.:|.|                       |.||:|
Zfish    72 SVGYGPISSPQMNMFPRNAEINSTVSMSGLHAVSSSDDVKPPFGLKPLSSHSPGPMVSQKRLCAI 136

  Fly   107 CGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKR 171
            ||||:|||||||||||||||||||||||||:|.||:|::|::|||||||||||||||||..||||
Zfish   137 CGDRSSGKHYGVYSCEGCKGFFKRTVRKDLSYTCRDNKDCLVDKRQRNRCQYCRYQKCLAMGMKR 201

  Fly   172 EAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSR 236
            |.||:||||..:....|      .....|.|..||                          :.:.
Zfish   202 EVVQDERQRSVQEERQR------NKERDGEVESSS--------------------------AANE 234

  Fly   237 DFSIERIIEAEQRAETQCGDRALTFLRV----GPYSTVQPDYKGAVSALCQVVNKQLFQMVEYAR 297
            :..:|:|:|||...|.:      |.|..    |..|...|     |:.:||..:||||.:||:|:
Zfish   235 EMPVEKILEAEMAVEQK------TELHADGSSGGSSPNDP-----VTNICQAADKQLFTLVEWAK 288

  Fly   298 MMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQ 362
            .:|||:::.||||||||:|.|.|||||:.:..|| ::.||
Zfish   289 RIPHFSELSLDDQVILLRAGWNELLIASFSHRSI-TVKDG------------------------- 327

  Fly   363 QLFLNQSFSYHRNSAIKAG--------------VSAIFDRILSELSVKMKRLNLDRRELSCLKAI 413
             :.|......|||||..||              |.|||||:|:||..||:.:.:|:.||.||:||
Zfish   328 -ILLATGLHVHRNSAHSAGVGAIFDRESAHNAEVGAIFDRVLTELVSKMRDMQMDKTELGCLRAI 391

  Fly   414 ILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFL 478
            ||:|||.:|:.|.:|:|:.||||||.|:.:|:..:|...||||:|||||||||||.|||.:|||.
Zfish   392 ILFNPDAKGLSSPSEVELLREKVYASLEAYCKQRYPDQQGRFAKLLLRLPALRSIGLKCLEHLFF 456

  Fly   479 FRITSDRPLEELFLEQLEAP 498
            |::..|.|::...:|.||||
Zfish   457 FKLIGDTPIDTFLMEMLEAP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	61/75 (81%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	108/260 (42%)
rxrba	XP_009292297.1	Nuc_recep-AF1	21..126	CDD:288658	14/104 (13%)
		NR_DBD_RXR	133..208	CDD:143514	61/74 (82%)
		NR_LBD_RXR_like	235..458	CDD:132741	108/260 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577459
Domainoid	1	1.000	188	1.000	Domainoid score	I3237
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	365	1.000	Inparanoid score	I2124
OMA	1	1.010	-	-		QHG45637
OrthoDB	1	1.010	-	-		D389616at33208
OrthoFinder	1	1.000	-	-		FOG0001500
OrthoInspector	1	1.000	-	-		otm25754
orthoMCL	1	0.900	-	-		OOG6_103349
Panther	1	1.100	-	-	O	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4818
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940