Protein Alignment usp and Nr2c1

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_665723.1
• Gene: Nr2c1 / 252924
• RGDID: 3200
• Length: 590
• Species: Rattus norvegicus
• Alignment Length: 525
• Identity: 138/525 - (26%)
• Similarity: 214/525 - (40%)
• Gaps: 153/525 - (29%)

  Fly    94 NHPLSGSK---HLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNR 155
            |.|..|..   .||.:|||:|||:|||..:||||||||||::||:|.|:||.:::|||:|..|||
  Rat    88 NSPDQGPNKVFDLCVVCGDKASGRHYGAITCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNR 152

  Fly   156 CQYCRYQKCLTCGMKREAVQEERQ--RGARNAAGRLSAS-------------------------- 192
            |||||.|:|:..|||:::||.||:  ..:|..:...:||
  Rat   153 CQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATPTFVTDSET 217

  Fly   193 ----GGGSSG------PGSV-----------GGSSSQGGGG---------------------GGG 215
                |...||      |..:           ...|.||..|                     ||.
  Rat   218 ARSTGLLDSGMFVNIHPSGIKTEPALLMTPDKAESCQGDLGTLASVVTSLANLGKAKDLSHCGGD 282

  Fly   216 V-------SGGMGSGNGSDDFMTN-SVSRDF--------------------SIE---RIIEAE-- 247
            :       :|....|....|..|| .|||.|                    |:|   .:|..|
  Rat   283 LPVVQSLRNGDTSFGAFHQDIQTNGDVSRAFDNLAKALTPGENPACQSPGESMEGSTHLIAGEPS 347

  Fly   248 --QRAETQCGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQ 310
              :|......|..:.|....|  :..|:|.. |..:.:..::.||..:.:|..:|.|..:..::.
  Rat   348 CMEREGPLLSDSHVVFRLTMP--SPMPEYLN-VHYIGESASRLLFLSMHWALSIPSFQALGQENS 409

  Fly   311 VILLKAAWIELLIANVAWC-----------SIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQL 364
            :.|:||.|.||....:|.|           :.|:.           |.:....::.||  :.::|
  Rat   410 ISLVKAYWNELFTLGLAQCWQVMNVATILATFVNC-----------LHNSLQQDKMSP--ERRKL 461

  Fly   365 FLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEI 429
            .:...|.                  |.|....|.:|.:|..|.:.||||:|::||..|:::...|
  Rat   462 LMEHIFK------------------LQEFCNSMVKLCIDGHEYAYLKAIVLFSPDHPGLENMELI 508

  Fly   430 EMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQ 494
            |..:||.|....::....:|.|..|.::|||||||||.::....:.||...:..:..::.:....
  Rat   509 EKFQEKAYVEFQDYITRTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRIDSVIPHI 573

  Fly   495 LEAPP 499
            |:..|
  Rat   574 LKMEP 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	46/75 (61%)
		NR_LBD_RXR_like	237..480	CDD:132741	64/280 (23%)
Nr2c1	NP_665723.1	Required for interaction with KAT2B. /evidence=ECO:0000250	1..166		44/77 (57%)
		NR_DBD_TR2_like	96..182	CDD:143525	48/85 (56%)
		NR_LBD_TR2_like	355..576	CDD:132750	59/254 (23%)
		Required for interaction with NRIP1. /evidence=ECO:0000250	571..590		2/8 (25%)