DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment usp and Rxra

DIOPT Version :9

Sequence 1:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_038960270.1	Gene:	Rxra / 25271	RGDID:	3610	Length:	507	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	209/487 - (42%)
Similarity:	277/487 - (56%)	Gaps:	90/487 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ISQLNDSNNSSFSPKA--ESPV-PFMQAMSMVHVL---PGSNSASSNNNSAGDAQMAQAPNSAGG 81
            ||.|:...|....|.:  .||: |...::.....|   .||...:|..|....::..:.|....|
  Rat    96 ISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFGTGSPQLNSPMNPVSSSEDIKPPLGLNG 160

  Fly    82 SAAAAVQQQYPPNHPLSG-----SKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACR 141
            ....       |.|| ||     :||:|:|||||:|||||||||||||||||||||||||||.||
  Rat   161 VLKV-------PAHP-SGNMSSFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCR 217

  Fly   142 ENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSS 206
            :|::|:||||||||||||||||||..||||||||||||||.
  Rat   218 DNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGK------------------------ 258

  Fly   207 SQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGPYSTVQ 271
                           ..|.::...|:|.:.|..:|:|:|||...|.:........:.:.|.|...
  Rat   259 ---------------DRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMGLNPSSPND 308

  Fly   272 PDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDD 336
            |     |:.:||..:||||.:||:|:.:|||:::|||||||||:|.|.|||||:.:..|| ::.|
  Rat   309 P-----VTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI-AVKD 367

  Fly   337 GGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLN 401
            |                          :.|......|||||..|||.|||||:|:||..||:.:.
  Rat   368 G--------------------------ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQ 406

  Fly   402 LDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALR 466
            :|:.||.||:||:|:|||.:|:.:.||:|..||||||.|:.:|:.::|...||||:|||||||||
  Rat   407 MDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALR 471

  Fly   467 SISLKCQDHLFLFRITSDRPLEELFLEQLEAP 498
            ||.|||.:|||.|::..|.|::...:|.||||
  Rat   472 SIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	65/75 (87%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	107/242 (44%)
Rxra	XP_038960270.1	Nuc_recep-AF1	58..171	CDD:403126	19/82 (23%)
		NR_DBD_RXR	178..254	CDD:143514	65/75 (87%)
		NR_LBD_RXR_like	274..485	CDD:132741	107/242 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338090
Domainoid	1	1.000	189	1.000	Domainoid score	I3200
eggNOG	1	0.900	-	-		E33208_3BA8J
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2220
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2108
OMA	1	1.010	-	-		QHG45637
OrthoDB	1	1.010	-	-		D389616at33208
OrthoFinder	1	1.000	-	-		FOG0001500
OrthoInspector	1	1.000	-	-		otm46466
orthoMCL	1	0.900	-	-		OOG6_103349
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770