Protein Alignment usp and NR2F6

DIOPT Version :9

• Sequence 1: NP_001259168.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_005225.2
• Gene: NR2F6 / 2063
• HGNCID: 7977
• Length: 404
• Species: Homo sapiens
• Alignment Length: 460
• Identity: 152/460 - (33%)
• Similarity: 212/460 - (46%)
• Gaps: 82/460 - (17%)

  Fly    48 MSMVHVLPGSNSASSNN-NSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHPLSGSKHLCSICGDRA 111
            |:||....|.....:|. :.||....|...:||....||:..:  |.:....|.:..|.:|||::
Human     1 MAMVTGGWGGPGGDTNGVDKAGGYPRAAEDDSASPPGAASDAE--PGDEERPGLQVDCVVCGDKS 63

  Fly   112 SGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQE 176
            |||||||::|||||.||||::|::|:|.||.||:|.||:..||:|||||.:||...||::||||
Human    64 SGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQ- 127

  Fly   177 ERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIE 241
             |.|...:..|.::||.|  |.|||...:.:.||                |.|....||     |
Human   128 -RGRIPHSLPGAVAASSG--SPPGSALAAVASGG----------------DLFPGQPVS-----E 168

  Fly   242 RIIEAEQRAETQCGDRALTFLRVGPYSTVQPDY---KGAVSA------LCQVVNKQLFQMVEYAR 297
            .|.:               .||..||......:   .||..|      :|::..:.||..||:||
Human   169 LIAQ---------------LLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWAR 218

  Fly   298 MMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQ 362
            ..|.|.::|:.|||.||:.:|.||.:.|.|..::..                    ..:|.|...
Human   219 HAPFFPELPVADQVALLRLSWSELFVLNAAQAALPL--------------------HTAPLLAAA 263

  Fly   363 QLFLNQSFSYHRNSAIKAGVSAIFD--RILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKS 425
            .|        |..........|..|  |...|...|:.||.:|..|..|||||.|:.||..|:..
Human   264 GL--------HAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSD 320

  Fly   426 RAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEEL 490
            .|.:|..:||....|.|:.|.::|....||.:|||||||||::.......||..|:....|:|.|
Human   321 PAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETL 385

  Fly   491 FLEQL 495
            ..:.|
Human   386 IRDML 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	45/75 (60%)
		NR_LBD_RXR_like	237..480	CDD:132741	72/253 (28%)
NR2F6	NP_005225.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		13/49 (27%)
		NR_DBD_COUP_TF	56..128	CDD:143516	45/73 (62%)
		NR_LBD_COUP-TF	165..400	CDD:132746	79/274 (29%)
		Important for dimerization. /evidence=ECO:0000250	327..404		24/64 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144367
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840