Protein Alignment usp and nhr-19

DIOPT Version :10

• Sequence 1: NP_476781.1
• Gene: usp / 31165
• FlyBaseID: FBgn0003964
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_496066.2
• Gene: nhr-19 / 174512
• WormBaseID: WBGene00003618
• Length: 477
• Species: Caenorhabditis elegans
• Alignment Length: 554
• Identity: 127/554 - (22%)
• Similarity: 200/554 - (36%)
• Gaps: 175/554 - (31%)

  Fly    23 ISQLNDSN----NSSFSPKAESPVPFMQAMSMVHVLPGSNSASSNNNSAGDAQMAQAPNSAGGSA 83
            ::.||.:|    .|.| ||.||.:                :|...:.|....:|....:.....:
 Worm    12 LAGLNIANFGAATSQF-PKLESEI----------------TAPRQSMSTAFQKMPTFTSVISVPS 59

  Fly    84 AAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCII 148
            .||:..|.|...|..|....|.|||:.::|||||:.:|.|||.||:|.|.:.....|:..:.|.:
 Worm    60 IAAIAPQMPSVKPEKGVIGQCLICGEPSTGKHYGIVACLGCKTFFRRAVVQRQDTECKREKPCDV 124

  Fly   149 DKRQRNRCQYCRYQKCLTCGMKREAVQEERQR-GARNAAGRLSASGGGSSGP------------- 199
            ....|..|:.|||:|||..||.:||:|..|.. |.|....|.|.|....:.|
 Worm   125 TTMARKACRACRYRKCLESGMSKEALQPRRDLIGCRRIRSRPSCSTSTPTPPRPQVEDKSQYLTL 189

  Fly   200 ----------------------------------GSVGGSSSQGGGGGGGVSGGMGSGNGSDDFM 230
                                              |.:..:.:.|......|.||. |.||.|..|
 Worm   190 LENLTTIDDRLRKKKLEVVASRQAAVDLAVLAKQGCMSITDTSGPSTSRYVPGGT-SPNGGDHKM 253

  Fly   231 TNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNKQLFQMVEY 295
            ...:..|.|:          .||                                 .:|..|:|:
 Worm   254 MVMLGTDISV----------STQ---------------------------------SELLMMLEW 275

  Fly   296 ARMMPHFAQVPLDDQVILLKAAWIELLI---------ANV--AW------C---SIVSLDDGGAG 340
            .|.:|.||.:|:.|:.::||...:..||         ||:  .|      |   ::..|::
 Worm   276 TRTLPVFASLPVQDRSVILKRFAVHCLILEHGYYTAQANIDDVWLITNGTCMPRNVEKLEE---- 336

  Fly   341 GGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNLDRR 405
                |.....|.:||   .:.::|:...:                 |..:.|::..::.|.|..:
 Worm   337 ----GCKISVSADRR---WRQEKLYKQMT-----------------DCCIDEVATPLRNLKLSPQ 377

  Fly   406 ELSCLKAIILYN----PDIRGI--KSRAEIEMCREKVYACL---DEHCRLEHPGDDGRFAQLLLR 461
            |:..:|.|:|:|    .|...|  .||..:...|.||.:.|   .|...|::..:  ||..|:|.
 Worm   378 EIVVIKIIVLFNCGCSSDYSEITEASRRIVLTFRNKVVSALFAYYESVGLQNYAE--RFGNLVLM 440

  Fly   462 LPALRSIS---LKCQDHLFLFRITSDRPLEELFL 492
            |..:.|.:   |:....:.||:||...||.:..|
 Worm   441 LSGVSSAASSMLEAYQVMRLFKITPFDPLSQELL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_476781.1	NR_DBD_RXR	102..178	CDD:143514	32/75 (43%)
		NR_LBD_RXR_like	237..480	CDD:132741	54/274 (20%)
nhr-19	NP_496066.2	NR_DBD_HNF4A	80..155	CDD:143518	32/74 (43%)
		HOLI	268..447	CDD:214658	47/208 (23%)