DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment usp and Hnf4a

DIOPT Version :9

Sequence 1:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_032287.2	Gene:	Hnf4a / 15378	MGIID:	109128	Length:	474	Species:	Mus musculus

Alignment Length:	446	Identity:	132/446 - (29%)
Similarity:	201/446 - (45%)	Gaps:	110/446 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 NNNSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGF 127
            |:.|..:.....:.||.|.||                   ||:||||||:|||||..||:|||||
Mouse    38 NDTSPSEGANLNSSNSLGVSA-------------------LCAICGDRATGKHYGASSCDGCKGF 83

  Fly   128 FKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSAS 192
            |:|:|||:..|:||.:|.|::||.:||:|:|||.:||...|||:||||.||.|     .....:|
Mouse    84 FRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDR-----ISTRRSS 143

  Fly   193 GGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDR 257
            ...||.|                                       ||..:::||
Mouse   144 YEDSSLP---------------------------------------SINALLQAE---------- 159

  Fly   258 ALTFLRVGPYSTVQPDYKGA----VSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAW 318
            .|:.....|.|.:..|.:..    ::.:|:.:.:||..:||:|:.:|.|.::.|||||.||:|..
Mouse   160 VLSQQITSPISGINGDIRAKKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHA 224

  Fly   319 IELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVS 383
            .|.|:......|:|..|                           .|.|...:...|:....|.:|
Mouse   225 GEHLLLGATKRSMVFKD---------------------------VLLLGNDYIVPRHCPELAEMS 262

  Fly   384 AIFDRILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEH 448
            .:..|||.||.:..:.|.:|..|.:||||||.::||.:|:....:|:..|.:|...|:::.....
Mouse   263 RVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQ 327

  Fly   449 PGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQL------EAP 498
            ....|||.:|||.||.|:||:.:..:.:...::.....::.|..|.|      :||
Mouse   328 YDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAP 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	47/75 (63%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	66/246 (27%)
Hnf4a	NP_032287.2	NR_DBD_HNF4A	60..135	CDD:143518	47/74 (64%)
		NR_LBD_HNF4_like	151..373	CDD:132729	67/258 (26%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P41235	368..376		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840