DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment usp and Nr2f2

DIOPT Version :9

Sequence 1:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_542956.1	Gene:	Nr2f2 / 113984	RGDID:	69305	Length:	414	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	146/482 - (30%)
Similarity:	212/482 - (43%)	Gaps:	112/482 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NDSNNSSFSPKAESPVPFMQAMSMVHV--LPGSNSASSNNNSAGDAQMAQAPNSAGGSAAAAVQQ 89
            :..:.:|.:|....|.|     ...|.  .||....:|.     .||.|.......|...:..||
  Rat    18 SQGSQASQAPPVPGPPP-----GAPHTPQTPGQGGPAST-----PAQTAAGSQGGPGGPGSDKQQ 72

  Fly    90 QYPPNHPLSGSKHL-CSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQR 153
            |         .:|: |.:|||::||||||.::|||||.||||:||::|:|.||.||||.||:..|
  Rat    73 Q---------QQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHR 128

  Fly   154 NRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSG 218
            |:|||||.:|||..||:|||||..|....:...|:.:.:.|......|
  Rat   129 NQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHS----------------- 176

  Fly   219 GMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGPYST-------VQPDYKG 276
                      :::..:|                        ..||..||.|       :||:...
  Rat   177 ----------YLSGYIS------------------------LLLRAEPYPTSRFGSQCMQPNNIM 207

  Fly   277 AVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGG 341
            .:..:|::..:.||..||:||.:|.|..:.:.|||.||:..|.||.:.|.|.||:
  Rat   208 GIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM---------- 262

  Fly   342 GGGGLGHDGSFERRSPGLQPQQLF-LNQSFSYHRNSAIKAGVSAIFD--RILSELSVKMKRLNLD 403
                               |..:. |..:...|.:......|.|..|  ||..|...|:|.|::|
  Rat   263 -------------------PLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVD 308

  Fly   404 RRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSI 468
            ..|.||||||:|:..|..|:...|.:|..:||....|:|:.|.::|....||.:||||||:||::
  Rat   309 SAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373

  Fly   469 SLKCQDHLFLFRITSDRPLEELFLEQL 495
            |....:.||..|:....|:|.|..:.|
  Rat   374 SSSVIEQLFFVRLVGKTPIETLIRDML 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	49/76 (64%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	72/252 (29%)
Nr2f2	NP_542956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72		12/63 (19%)
		NR_DBD_COUP_TF	79..151	CDD:143516	47/71 (66%)
		Interaction with ZFPM2. /evidence=ECO:0000250	117..414		105/364 (29%)
		NR_LBD_COUP-TF	177..411	CDD:132746	78/277 (28%)
		Important for dimerization	337..414		24/64 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338088
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840