Protein Alignment PIG-K and PIGK

DIOPT Version :10

• Sequence 1: NP_569968.2
• Gene: PIG-K / 31163
• FlyBaseID: FBgn0023545
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_005473.1
• Gene: PIGK / 10026
• HGNCID: 8965
• Length: 395
• Species: Homo sapiens
• Alignment Length: 347
• Identity: 204/347 - (58%)
• Similarity: 257/347 - (74%)
• Gaps: 15/347 - (4%)

  Fly    10 VVIFALILASCRVEADNTSVLPEGFVDAAQRSTHTNNWAVLVDASRFWFNYRHVANVLSIYRSVK 74
            |:...|:|:...|.|.:.....|.|.    ||.|||||||||..||||||||||||.||:|||||
Human    13 VLATVLLLSFGSVAASHIEDQAEQFF----RSGHTNNWAVLVCTSRFWFNYRHVANTLSVYRSVK 73

  Fly    75 RLGIPDSQIILMIADDMACNARNPRPGQVYNNANQHINVYGDDVEVDYRGYEVTVENFVRLLTGR 139
            |||||||.|:||:|||||||.|||:|..|:::.|..:||||||||||||.||||||||:|:||||
Human    74 RLGIPDSHIVLMLADDMACNPRNPKPATVFSHKNMELNVYGDDVEVDYRSYEVTVENFLRVLTGR 138

  Fly   140 TQNGTARSKKLLSDAGSNVLIYLTGHGGDGFLKFQDSEEITSQELADGIQQMWEKKRYNELFFMV 204
            ....|.|||:||||..||:|||:|||||:||||||||||||:.||||..:|||:|:|||||.|::
Human   139 IPPSTPRSKRLLSDDRSNILIYMTGHGGNGFLKFQDSEEITNIELADAFEQMWQKRRYNELLFII 203

  Fly   205 DTCQAASLYEKFTSPNVLAVASSLVGEDSLSHHVDPSIGVYMIDRYTYYALEFLEKVQPFSKRTI 269
            ||||.||:||:|.|||::|:|||.||||||||..||:|||:::||||:|.|||||::.|.|:..:
Human   204 DTCQGASMYERFYSPNIMALASSQVGEDSLSHQPDPAIGVHLMDRYTFYVLEFLEEINPASQTNM 268

  Fly   270 GEFLQVCPKRVCISTVGVRKDLYPRDPHKVPITDFFGAIRPTRVSTDRINVTLANEDDFI----F 330
            .:..|||||.:|:||.|.|.||:.|||..|.||||||::|...::|:.|.:   .:|..|    :
Human   269 NDLFQVCPKSLCVSTPGHRTDLFQRDPKNVLITDFFGSVRKVEITTETIKL---QQDSEIMESSY 330

  Fly   331 DKDKMVTK--KPFKIVMESQFP 350
            .:|:|..|  :|.|..  .|.|
Human   331 KEDQMDEKLMEPLKYA--EQLP 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIG-K	NP_569968.2	Peptidase_C13	46..271	CDD:396290	158/224 (71%)
PIGK	NP_005473.1	CASc	45..273	CDD:444667	158/227 (70%)
		Autoinhibitory loop. /evidence=ECO:0000269|PubMed:37684232	231..236		4/4 (100%)