Protein Alignment Hr4 and Nr5a1

DIOPT Version :9

• Sequence 1: NP_001259161.1
• Gene: Hr4 / 31162
• FlyBaseID: FBgn0264562
• Length: 2123
• Species: Drosophila melanogaster
• Sequence 2: NP_001178028.1
• Gene: Nr5a1 / 83826
• RGDID: 68350
• Length: 462
• Species: Rattus norvegicus
• Alignment Length: 616
• Identity: 136/616 - (22%)
• Similarity: 209/616 - (33%)
• Gaps: 205/616 - (33%)

  Fly   913 DEDEQPLVCMICEDKATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNRCQYCR 977
            |||...| |.:|.||.:|.|||::|||.|||||||||||.:.|||....:|:|.|.||.||.:||
  Rat     6 DEDLDEL-CPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCR 69

  Fly   978 FKKCIEQGMVLQAVREDRMPGGRNSGAVYNLYKVKYKKHKKTNQKQQQQAAQQQQQQAAAQQQHQ 1042
            |:||:..||.|:|||.|||.||||.      :...||:.:...|:::.|......:.........
  Rat    70 FQKCLTVGMRLEAVRADRMRGGRNK------FGPMYKRDRALKQQKKAQIRANGFKLETGPPMGV 128

  Fly  1043 QQQQHQQHQQHQQQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLS-PQQQQL------AAAV 1100
            ...............||:|                      .|..|:| |....|      :..:
  Rat   129 PPPPPPPPDYMLPPSLHAP----------------------EPKALVSGPPSGPLGDFGAPSLPM 171

  Fly  1101 AAAAQHQQQQQQQQQQQQQAKLMGGVVDMKPMFLGPALK---PELLQAPPMHSPAQQQQQQQQQQ 1162
            |....|             ..|.|   .:.|.|....:|   ||...:||
  Rat   172 AVPGPH-------------GPLAG---YLYPAFSNRTIKSEYPEPYASPP--------------- 205

  Fly  1163 QQQQASPHLSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTALTNPSEI 1227
              ||..|..|...|.                        .||..:|.     .||:.....|.|
  Rat   206 --QQPGPPYSYPEPF------------------------SGGPNVPE-----LILQLLQLEPEE- 238

  Fly  1228 VHLRHRLDSAVSSSKDRQISYEHALGMIQTLIDCDAMEDIATLPHFSEFLEDKSEISEKLCNIGD 1292
            ..:|.|:                 :|.:|        |...:.|       |:......||.:.|
  Rat   239 DQVRARI-----------------VGCLQ--------EPAKSRP-------DQPAPFSLLCRMAD 271

  Fly  1293 SIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAYQALHGKRRGEGGGSRHGSPAST 1357
            .....:|.|.::...:.|:.|.....||.:.|.|:|:|.....|..:||
  Rat   272 QTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGK---------------- 320

  Fly  1358 PLSTPTGTPLSTPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCLTTLMGQPIAMEQLKLDVGHMVD 1422
                                                   :..:..:.||.:.:..:.:..|.::.
  Rat   321 ---------------------------------------EDSILLVTGQEVELSTVAVQAGSLLH 346

  Fly  1423 KMT----QITIMFRRIKLKMEEYVCLKVYIL-------LNKAEVELESIQERYVQVLRSYLQNSS 1476
            .:.    ::.:....::|..:|:||||..||       ||...: ::..||:....|..|.....
  Rat   347 SLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSL-VKDAQEKANAALLDYTLCHY 410

  Fly  1477 PQNPQARLSELLSHIPEIQAAASLLLESKMF 1507
            |.... :..:||..:.|::|   |.:::|.:
  Rat   411 PHCGD-KFQQLLLCLVEVRA---LSMQAKEY 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr4	NP_001259161.1	NR_DBD_DHR4_like	913..1002	CDD:143542	53/88 (60%)
		NR_LBD_DHR4_like	1256..1515	CDD:132751	44/263 (17%)
Nr5a1	NP_001178028.1	NR_DBD_Lrh-1_like	13..105	CDD:143541	52/97 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..149		3/53 (6%)
		NR_LBD_SF-1	224..460	CDD:132755	52/312 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920