DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr4 and Eip75B

DIOPT Version :9

Sequence 1:	NP_001259161.1	Gene:	Hr4 / 31162	FlyBaseID:	FBgn0264562	Length:	2123	Species:	Drosophila melanogaster
Sequence 2:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster

Alignment Length:	1942	Identity:	400/1942 - (20%)
Similarity:	625/1942 - (32%)	Gaps:	714/1942 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 KAVAAAAAAAAAGHVTVLVTPSRIKSEPPPPASPSSTSSTQRERERERDRERDRERERERDRDRE 424
            :||.|||||.::|           .|....|.|.|.::|...:.| ..|.|.....|.||.:|.|
  Fly     2 EAVQAAAAATSSG-----------GSSGSVPGSGSGSASKLIKTE-PIDFEMLHLEENERQQDIE 54

  Fly   425 REREQSISSSQQHLSRVSASPPTQLSHGSLGPNIVQTHHLHQQ--LTQPLTLRK--SSPPTEHLL 485
            ||...|.|:|..     ::..|.:.:|..     |||....|.  ||.|...:|  .:|..|::
  Fly    55 REPSSSNSNSNS-----NSLTPQRYTHVQ-----VQTVPPRQPTGLTTPGGTQKVILTPRVEYV- 108

  Fly   486 SQSMQHLTQQQAIHLHHLLGQQQ--QQQQASHPQQQQQQQHSPHSLVRVKKEPNV-------GQR 541
               .|..|......:.|:..|||  ...:::.|:       :...|......|.:       ..:
  Fly   109 ---QQRATSSTGGGMKHVYSQQQGTAASRSAPPE-------TTALLTTTSGTPQIIITRTLPSNQ 163

  Fly   542 HLSPHHQQQSPLLQHHQQQQQQQQQQQQHLHQQQQQQQHHQQQPQALALMHPASLALRNSNRDAA 606
            |||..|......|.|:||||.|:||....||.||||||.|.:..:...|...|::.
  Fly   164 HLSRRHSASPSALHHYQQQQPQRQQSPPPLHHQQQQQQQHVRVIRDGRLYDEATVV--------- 219

  Fly   607 ILFRVKSEVHQQVAAGLPHLMQSA---------GGAAAAAAAAVAAQRMVCFSNARINGVKPEVI 662
                |.:..|......|.|..:||         |||||
  Fly   220 ----VAARRHSVSPPPLHHHSRSAPVSPVIARRGGAAA--------------------------- 253

  Fly   663 GGPLGNLRPVGVGGGNGSGSVQCPSPHPSSSSSSSQLSPQTPSQTPPRGTPTVIMGESCGVRTMV 727
                                      :........|..|..|...||...|
  Fly   254 --------------------------YMDQQYQQRQTPPLAPPPPPPPPPP-------------- 278

  Fly   728 WGYEPPPPSAGQSHGQHPQQQQQ-----------------------------SPHHQPQQQQQQQ 763
                ||||         ||||||                             :.:|..|||||.|
  Fly   279 ----PPPP---------PQQQQQQYISTGVPPPTAAARKFVVSTSTRHVNVIASNHFQQQQQQHQ 330

  Fly   764 QQQSQQQQQQQQQQSLGQQQHCLSSPSAGSLTPSSSSGGGSVSGGGVGGPLTPSSVAP--QNNEE 826
            .||.|||.||.||    .|||.::|.|:.| :.|:...|||.|......|:..||.:.  .:.::
  Fly   331 AQQHQQQHQQHQQ----HQQHVIASVSSSS-SSSAIGSGGSSSSHIFRTPVVSSSSSSNMHHQQQ 390

  Fly   827 AAQLLLSLGQTRIQDMRSRPHPFRTPHALNMERLWAGDYSQLPPGQLQALNLSAQQQQWGSSNST 891
            ..|...|||.:   .||..|.|                    ||.:::..:.|:.    |:|:|:
  Fly   391 QQQQQSSLGNS---VMRPPPPP--------------------PPPKVKHASSSSS----GNSSSS 428

  Fly   892 GLGGVGGGMGGRNLEAPHEPTDEDEQPLVCMICEDKATGLHYGIITCEGCKGFFKRTVQNRRVY- 955
            ..........|....:.....:.|...::|.:|.|||:|.|||:.:||||||||:|::|.:..|
  Fly   429 NTNNSSSSSNGEEPSSSIPDLEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYR 493

  Fly   956 TCVADGTCEITKAQRNRCQYCRFKKCIEQGMVLQAVREDRMPGGRNSGAVYNLYKVKYKKHKKTN 1020
            .|..:..|.|.:..||||||||.||||..||...|||..|:|                |:.|...
  Fly   494 PCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVP----------------KREKARI 542

  Fly  1021 QKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQHQQQQLHSPLHHHHHQGHQSHHAQQQHHPQLSP 1085
            ....||:.|.:.||.|...:
  Fly   543 LAAMQQSTQNRGQQRALATE--------------------------------------------- 562

  Fly  1086 HHLLSPQQQQLAAAVAAAAQH-QQQQQQQQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAPPMH 1149
               |..|.:.|||.:.|..:. :..:::....:|:|:      |.      |:.....|.|.|:
  Fly   563 ---LDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRAR------DC------PSYSMPTLLACPL- 611

  Fly  1150 SPAQQQQQQQQQQQQQQASPHLSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNG 1214
            :||                       |..|.:|:..|...|..:......|...|.||.......
  Fly   612 NPA-----------------------PELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKF 653

  Fly  1215 TILKTALTNPSEIVHLRHRLDSAVSSSKDRQISYEHALGMIQTLIDC--------DAMEDIATLP 1271
            |:||..|.: :..|.|....||:::|                  |.|        ||:::.|.
  Fly   654 TLLKAGLFD-ALFVRLICMFDSSINS------------------IICLNGQVMRRDAIQNGAN-- 697

  Fly  1272 HFSEFLEDKS-EISEKLCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAY 1335
              :.||.|.: ..:|::.::.                            |||.  ||
  Fly   698 --ARFLVDSTFNFAERMNSMN----------------------------LTDA--EI-------- 722

  Fly  1336 QALHGKRRGEGGGSRHGSPASTPLSTPTGTPLSTPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCL 1400
                            |...:..|.||                  |.|
  Fly   723 ----------------GLFCAIVLITP------------------DRP----------------- 736

  Fly  1401 TTLMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKLKMEEYVCLKVYILLNKAEVELESIQERYV 1465
                    .:..|:|     ::|      |:.|:|      .||:..:..|:
  Fly   737 --------GLRNLEL-----IEK------MYSRLK------GCLQYIVAQNR------------- 763

  Fly  1466 QVLRSYLQNSSPQNPQARLSELLSHIPEIQAAASLLLESKMFYVPFVLNSASIRXQMLEHGLLPT 1530
                       |..|:. |::||..:|:::..::|..|..:.:             ..||
  Fly   764 -----------PDQPEF-LAKLLETMPDLRTLSTLHTEKLVVF-------------RTEH----- 798

  Fly  1531 ANHQSAPPPGPDTIPERQQQQQQERRRSRQQQHQL-------LRNLPKIKIEIGSQRDPEEEESE 1588
                       ..:..:|....::...|..||::.       ..::...|..:||....|..:.:
  Fly   799 -----------KELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVSSTESADLD 852

  Fly  1589 QELEQEPEQEQDV------QSRPSAASTSILKTSLLSGAAATLATLTAAAEQIARSSASCDTARD 1647
            .. .....|.|.|      |.:|||         |.|.|....|||          |..|    .
  Fly   853 YG-SPSSSQPQGVSLPSPPQQQPSA---------LASSAPLLAATL----------SGGC----P 893

  Fly  1648 YSQSSNSSSNSNAATGATGTMASGRTGSSNSLEESKRLEHQQQQQQQQ----------------- 1695
            ....:||.|:.::.......:.|....:.|.|..:..:.|||||||||
  Fly   894 LRNRANSGSSGDSGAAEMDIVGSHAHLTQNGLTITPIVRHQQQQQQQQQIGILNNAHSRNLNGGH 958

  Fly  1696 ---QQPQQHQQQQYTSILHTALMSQRSMPPATSATSAAAAVTSTPTTAATTSPTPAHVLKTAVTL 1757
               ||.|||.|      ||..|          :|.:|......:||.:...|....:..| ||:.
  Fly   959 AMCQQQQQHPQ------LHHHL----------TAGAARYRKLDSPTDSGIESGNEKNECK-AVSS 1006

  Fly  1758 ASLSEIATARQQQQE--------QQQQQQQQQQQQQLLAM----QQQQQQLTKLPRRIIN----- 1805
            ...|..::.|....:        ....|..|..|..::::    ..|....:.|.|:|:.
  Fly  1007 GGSSSCSSPRSSVDDALDCSDAAANHNQVVQHPQLSVVSVSPVRSPQPSTSSHLKRQIVEDMPVL 1071

  Fly  1806 ---------FGSNHTANTATK------ALGAGSEAGAGAGVGMATATATATVGRNRQLGLSQGQV 1855
                     :.:|...:.|.|      ||....         ..||.|.|:...:....||.|
  Fly  1072 KRVLQAPPLYDTNSLMDEAYKPHKKFRALRHRE---------FETAEADASSSTSGSNSLSAG-- 1125

  Fly  1856 VNVRTARLLNGNCCGRLQATAGTGASRGTNTAGSNTVNMQTQTDDELLPLLAMLPQDAPTTTGAA 1920
             :.|.:.:.|         :..|......:.|..|....|         |...|.:.:|..:.|:
  Fly  1126 -SPRQSPVPN---------SVATPPPSAASAAAGNPAQSQ---------LHMHLTRSSPKASMAS 1171

  Fly  1921 AGAAVSLSLLATATAT-----------------TTSSSSSSSSSLSSSSTISLATRAAAVMQQQQ 1968
            :.:.::.||:|....|                 .::::||:::.:.:.|..|.:|...:.:|.||
  Fly  1172 SHSVLAKSLMAEPRMTPEQMKRSDIIQNYLKRENSTAASSTTNGVGNRSPSSSSTPPPSAVQNQQ 1236

  Fly  1969 QWTAVSTTPATGVMMTTTTTQSQSQATLAPQQQQLSLPQQKQQFNTRINRKTTITTATTTAPT-- 2031
            :|         |.....|||..|.|.:::|.....|........::..:..|:...::::|.:
  Fly  1237 RW---------GSSSVITTTCQQRQQSVSPHSNGSSSSSSSSSSSSSSSSSTSSNCSSSSASSCQ 1292

  Fly  2032 ----------ATTATTTTTRNSN------------------INFNSNNNYMNNNNINAATARASA 2068
                      .|:|..:::..||                  :|.:..:.....:.::|..|.|:|
  Fly  1293 YFQSPHSTSNGTSAPASSSSGSNSATPLLELQVDIADSAQPLNLSKKSPTPPPSKLHALVAAANA 1357

  Fly  2069 F-----ASASAMATATPTGTPTATGPRQRPAPQPPPPPRTPTATSASVTVVVFKTML 2120
            .     .||....||:..|.|:|..   .|||. ..||.:..:.:..::..|.|.||
  Fly  1358 VQRYPTLSADVTVTASNGGPPSAAA---SPAPS-SSPPASVGSPNPGLSAAVHKVML 1410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr4	NP_001259161.1	NR_DBD_DHR4_like	913..1002	CDD:143542	43/89 (48%)
Hr4	NP_001259161.1	NR_LBD_DHR4_like	1256..1515	CDD:132751	37/267 (14%)
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	44/103 (43%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	58/385 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910