Protein Alignment Hr4 and Nr6a1

DIOPT Version :10

• Sequence 1: NP_001259161.1
• Gene: Hr4 / 31162
• FlyBaseID: FBgn0264562
• Length: 2123
• Species: Drosophila melanogaster
• Sequence 2: XP_038962169.2
• Gene: Nr6a1 / 362125
• RGDID: 1564740
• Length: 571
• Species: Rattus norvegicus
• Alignment Length: 879
• Identity: 192/879 - (21%)
• Similarity: 306/879 - (34%)
• Gaps: 345/879 - (39%)

  Fly   647 VCFSNARINGVKPEVIGGPLGNLRPVGVGGGNGSGSVQCPSPHPSSSSSSSQLSPQTPSQTPPRG 711
            :|.:.||      :|.||....||..| ..|.|:|.::    .|..|::.|..:|.:|  .||.|
  Rat     1 MCVAAAR------DVRGGSWPVLRGRG-AEGRGAGWLR----GPECSAAESLPAPDSP--LPPGG 52

  Fly   712 TPTVIMGESC-GVRTMVWGYEPPPPSAGQSHGQHPQQQQQSPHHQPQQQQQQQQQQSQQQQQQQQ 775
            .|    |... |.|:  |               ...:..:.|.|:..::.::
  Rat    53 RP----GRRLRGRRS--W---------------RNIEASEGPEHRRMERDER------------- 83

  Fly   776 QQSLGQQQHCLSSPSAGSLTPSSSSGGGSVSGGGVGGPLTPSSVAPQNNEEAAQLLLSLGQTRIQ 840
                                |.|..||    |||..|.|.|.:..|
  Rat    84 --------------------PPSGGGG----GGGSAGFLEPPAALP------------------- 105

  Fly   841 DMRSRPHPFRTPHALNMERLWAGDYSQLPPGQLQALNLSAQQQQWGSSNSTGLGGVGGGMGGRNL 905
                 |.|        .......:.::|.|                        |..|...|..|
  Rat   106 -----PPP--------RNGFCQDELAELDP------------------------GTNGETDGLTL 133

  Fly   906 EAPHEPT---DEDEQPLVCMICEDKATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGTCEITK 967
            ...|.|.   |:..:...|:||.|:|||||||||:||||||||||::.|:|||.|..|..|.:::
  Rat   134 GQGHIPVSVPDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSR 198

  Fly   968 AQRNRCQYCRFKKCIEQGMVLQAVREDRMPGGRNS--GAVYNLYKVKYKKHKKTNQKQQQQAAQQ 1030
            .|||||||||..||::.||..:|:|||.||||||.  |.|                    |.:::
  Rat   199 KQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPV--------------------QISEE 243

  Fly  1031 QQQQAAAQQQHQQQQQHQQHQQHQQQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLSPQQQQ 1095
            :.::..:.|:.:::..|..              :|....|.|...:.....|.||...||.:..:
  Rat   244 EIERIMSGQEFEEEANHWS--------------NHGDSDHSSPGNRVSESNQPSPGSTLSSRSVE 294

  Fly  1096 LAAAVAAAAQHQQQQQQQQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAPPMHSPAQQQQQQQQ 1160
            |                           .|.:..:..::|       :..||.:
  Rat   295 L---------------------------NGFMTFRDQYMG-------MSVPPHY----------- 314

  Fly  1161 QQQQQQASPHLSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTALTNPS 1225
                 |..|||...|.|                          ...|||.
  Rat   315 -----QYIPHLFSYSGH--------------------------SPLLPPQ--------------- 333

  Fly  1226 EIVHLRHRLDSAVSSSKDRQISYEHALGMIQTLIDCDAMEDIATLPHFSE--FLEDKSEISEKLC 1288
                         :.|.|.| ||    .:|..|:..:.:|.:.| |...|  :...::|:...||
  Rat   334 -------------ARSLDPQ-SY----SLIHQLMSAEDLEPLGT-PMLIEDGYAVTQAELFALLC 379

  Fly  1289 NIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAYQALHGKRRGEGGGSRHGS 1353
            .:.|.::.:.::|.|||||:.|:.::.:|.||:..|.|:::|::.   .::.|:       ..|.
  Rat   380 RLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSL---TVYSKQ-------IFGE 434

  Fly  1354 PASTPLSTPTGTPLSTPIPSPA-QPLHKDDPEFVSEVNSHLSTLQTCLTTLMGQPIAMEQLKLDV 1417
            .|..           |...||: :.||:...|                        .||
  Rat   435 LADV-----------TAKYSPSDEELHRFSDE------------------------GME------ 458

  Fly  1418 GHMVDKMTQITIMFRRIKLKMEEYVCLKVYILLNK------AEVELESIQERYVQVLRSYLQNSS 1476
              :::::..:...|.::|:..|||.|:|....||:      :..:||.:.:||..:.:.:.:...
  Rat   459 --VIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLSSASQLEQLNKRYWYICQDFTEYKY 521

  Fly  1477 PQNPQARLSELLSHIPEIQAAASLLLESKMFYVP 1510
            ...|. |..:|:..:|||:..|     .||..||
  Rat   522 THQPN-RFPDLMMCLPEIRYIA-----GKMVNVP 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr4	NP_001259161.1	NR_DBD_DHR4_like	913..1002	CDD:143542	53/88 (60%)
		NR_LBD_DHR4_like	1256..1515	CDD:132751	57/264 (22%)
Nr6a1	XP_038962169.2	None