DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr4 and Nr6a1

DIOPT Version :9

Sequence 1:	NP_001259161.1	Gene:	Hr4 / 31162	FlyBaseID:	FBgn0264562	Length:	2123	Species:	Drosophila melanogaster
Sequence 2:	XP_017447631.2	Gene:	Nr6a1 / 362125	RGDID:	1564740	Length:	495	Species:	Rattus norvegicus

Alignment Length:	725	Identity:	163/725 - (22%)
Similarity:	265/725 - (36%)	Gaps:	274/725 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   800 SGGGSVSGGGVGGPLTPSSVAPQNNEEAAQLLLSLGQTRIQDMRSRPHPFRTPHALNMERLWAGD 864
            ||||  .|||..|.|.|.:..|                        |.|        .......:
  Rat     9 SGGG--GGGGSAGFLEPPAALP------------------------PPP--------RNGFCQDE 39

  Fly   865 YSQLPPGQLQALNLSAQQQQWGSSNSTGLGGVGGGMGGRNLEAPHEPT---DEDEQPLVCMICED 926
            .::|.|                        |..|...|..|...|.|.   |:..:...|:||.|
  Rat    40 LAELDP------------------------GTNGETDGLTLGQGHIPVSVPDDRAEQRTCLICGD 80

  Fly   927 KATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNRCQYCRFKKCIEQGMVLQAV 991
            :|||||||||:||||||||||::.|:|||.|..|..|.:::.|||||||||..||::.||..:|:
  Rat    81 RATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAI 145

  Fly   992 REDRMPGGRNS--GAVYNLYKVKYKKHKKTNQKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQHQ 1054
            |||.||||||.  |.|                    |.::::.::..:.|:.:::
  Rat   146 REDGMPGGRNKSIGPV--------------------QISEEEIERIMSGQEFEEE---------- 180

  Fly  1055 QQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLSPQQQQLAAAVAAAAQHQQQQQQQQQQQQQ 1119
                         ..|.|:|....|.   ||.:.:|...|....:..::::..:
  Rat   181 -------------ANHWSNHGDSDHS---SPGNRVSESNQPSPGSTLSSSRSVE----------- 218

  Fly  1120 AKLMGGVVDMKPMFLGPALKPELLQAPPMHSPAQQQQQQQQQQQQQQASPHLSLSSPHQQQQQQQ 1184
               :.|.:..:..::|       :..||.:                |..|||...|.|
  Rat   219 ---LNGFMTFRDQYMG-------MSVPPHY----------------QYIPHLFSYSGH------- 250

  Fly  1185 GQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTALTNPSEIVHLRHRLDSAVSSSKDRQISYE 1249
                               ...|||.                            :.|.|.| ||
  Rat   251 -------------------SPLLPPQ----------------------------ARSLDPQ-SY- 266

  Fly  1250 HALGMIQTLIDCDAMEDIATLPHFSE--FLEDKSEISEKLCNIGDSIVHKLVSWTKKLPFYLEIP 1312
               .:|..|:..:.:|.:.| |...|  :...::|:...||.:.|.::.:.::|.|||||:.|:.
  Rat   267 ---SLIHQLMSAEDLEPLGT-PMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELS 327

  Fly  1313 VEIHTKLLTDKWHEILILTTAAYQALHGKRRGEGGGSRHGSPASTPLSTPTGTPLSTPIPSPA-Q 1376
            ::.:|.||:..|.|:::|::.   .::.|:       ..|..|..           |...||: :
  Rat   328 IKDYTCLLSSTWQELILLSSL---TVYSKQ-------IFGELADV-----------TAKYSPSDE 371

  Fly  1377 PLHKDDPEFVSEVNSHLSTLQTCLTTLMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKLKMEEY 1441
            .||:...|                        .||        :::::..:...|.::|:..|||
  Rat   372 ELHRFSDE------------------------GME--------VIERLIYLYHKFHQLKVSNEEY 404

  Fly  1442 VCLKVYILLNK------AEVELESIQERYVQVLRSYLQNSSPQNPQARLSELLSHIPEIQAAASL 1500
            .|:|....||:      :..:||.:.:||..:.:.:.:......|. |..:|:..:|||:..|
  Rat   405 ACMKAINFLNQDIRGLSSASQLEQLNKRYWYICQDFTEYKYTHQPN-RFPDLMMCLPEIRYIA-- 466

  Fly  1501 LLESKMFYVP 1510
               .||..||
  Rat   467 ---GKMVNVP 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr4	NP_001259161.1	NR_DBD_DHR4_like	913..1002	CDD:143542	53/88 (60%)
Hr4	NP_001259161.1	NR_LBD_DHR4_like	1256..1515	CDD:132751	57/264 (22%)
Nr6a1	XP_017447631.2	NR_DBD_GCNF_like	67..156	CDD:143543	53/88 (60%)
Nr6a1	XP_017447631.2	NR_LBD_DHR4_like	271..482	CDD:132751	57/263 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6335
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108526
Panther	1	1.100	-	-	LDO	PTHR48092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4570
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920