Protein Alignment Hr4 and nr6a1a

DIOPT Version :9

• Sequence 1: NP_001259161.1
• Gene: Hr4 / 31162
• FlyBaseID: FBgn0264562
• Length: 2123
• Species: Drosophila melanogaster
• Sequence 2: NP_571331.2
• Gene: nr6a1a / 30506
• ZFINID: ZDB-GENE-991207-19
• Length: 477
• Species: Danio rerio
• Alignment Length: 658
• Identity: 153/658 - (23%)
• Similarity: 243/658 - (36%)
• Gaps: 222/658 - (33%)

  Fly   899 GMGGRNLEAPHEPTDEDEQPLVCMICEDKATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGTC 963
            |.||..::|......:..:...|:||.|:|||||||||:||||||||||::.|:|||.|..|..|
Zfish    21 GHGGVLIDAEENGIHDQAEQRSCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNC 85

  Fly   964 EITKAQRNRCQYCRFKKCIEQGMVLQAVREDRMPGGRNS--GAVYNLYKVKYKKHKKTNQKQQQQ 1026
            |:::.|||||||||..||::.||..:|:|||.||||||.  |.|                    |
Zfish    86 EMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPV--------------------Q 130

  Fly  1027 AAQQQQQQAAAQQQHQQQQQHQQHQQHQQQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLSP 1091
            .:.::.::..:.|:.             :.:.:.|.|...:.|...|.         ||.:.:|.
Zfish   131 ISDEEIERIMSGQEF-------------KDEANMPEHTWGNNGDSDHS---------SPGNGVSD 173

  Fly  1092 QQQQLAAAVAAAAQHQQQQQQQQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAPPMHSPAQQQQ 1156
            ..|....:..::             .:..:|.|....::..::|.|:
Zfish   174 GNQPSPVSTLSS-------------NRSVELNGYTTALREQYIGNAM------------------ 207

  Fly  1157 QQQQQQQQQQASPHLSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTAL 1221
                 .|..|..|||.                              |.|..|..|
Zfish   208 -----AQHYQFLPHLF------------------------------GYAAQPRSL---------- 227

  Fly  1222 TNPSEIVHLRHRLDSAVSSSKDRQISYEHALGMIQTLIDCDAMEDIATL--PHFSE--FLEDKSE 1282
                                      |..:..:|..|:   |.||:|.|  |...|  :...:.|
Zfish   228 --------------------------YPQSHTLIGQLV---AAEDLAPLGTPMLIEDGYRVTQVE 263

  Fly  1283 ISEKLCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILI---LTTAAYQALHGKRRG 1344
            :...||.:.|.::.:.:||.|||||:.::.:|.:|:||:..|.|:::   ||..:.|.|
Zfish   264 LFALLCRLADELLFRQISWIKKLPFFCDLSIEDYTRLLSATWQELILLACLTVYSAQVL------ 322

  Fly  1345 EGGGSRHGSPASTPLSTPTGTPLSTPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCLTTLMGQPIA 1409
                   |..|:.       |...||.........:|..|
Zfish   323 -------GDLANV-------THKYTPSDDELHSFSEDGME------------------------- 348

  Fly  1410 MEQLKLDVGHMVDKMTQITIMFRRIKLKMEEYVCLKVYILLNK------AEVELESIQERYVQVL 1468
                      :::|:..:...|.::|:..|||.|:|....||:      ...:||.:.:||..|.
Zfish   349 ----------VMEKLIYLFRKFHQLKVSNEEYACMKAINFLNQDIRGLTNVTQLEQLNKRYWYVC 403

  Fly  1469 RSYLQNSSPQNPQARLSELLSHIPEIQAAASLLLESKMFYVPF----VLNSASIRXQMLEHGLLP 1529
            :.|.:...|..|: |..|::..:|||:..|..|:...:..:|.    ||:|.............|
Zfish   404 QDYTEYKYPHQPK-RFPEIMMCLPEIRCIAGKLVNIPLEQLPLLFKAVLHSCKSSLSSYRTSSSP 467

  Fly  1530 TANHQSAP 1537
            .....:||
Zfish   468 CVTKGTAP 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr4	NP_001259161.1	NR_DBD_DHR4_like	913..1002	CDD:143542	53/88 (60%)
		NR_LBD_DHR4_like	1256..1515	CDD:132751	64/275 (23%)
nr6a1a	NP_571331.2	NR_DBD_GCNF_like	36..124	CDD:143543	53/87 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..187		8/61 (13%)
		NR_LBD_DHR4_like	237..449	CDD:132751	62/270 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595658
Domainoid	1	1.000	111	1.000	Domainoid score	I6197
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto39210
orthoMCL	1	0.900	-	-		OOG6_108526
Panther	1	1.100	-	-	LDO	PTHR48092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4605
SonicParanoid	1	1.000	-	-		X4570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880