DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr4 and NR6A1

DIOPT Version :9

Sequence 1:	NP_001259161.1	Gene:	Hr4 / 31162	FlyBaseID:	FBgn0264562	Length:	2123	Species:	Drosophila melanogaster
Sequence 2:	NP_201591.2	Gene:	NR6A1 / 2649	HGNCID:	7985	Length:	480	Species:	Homo sapiens

Alignment Length:	726	Identity:	159/726 - (21%)
Similarity:	262/726 - (36%)	Gaps:	284/726 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   796 PSSSSGGGSVSGGGVGGPLTPSSVAPQNNEEAAQLLLSLGQTRIQDMRSRPHPFRTPHALNMERL 860
            |..|.|||   |||..|.|.|.:..|                        |.|        ....
Human     6 PPPSGGGG---GGGSAGFLEPPAALP------------------------PPP--------RNGF 35

  Fly   861 WAGDYSQLPPGQLQALNLSAQQQQWGSSNSTGLGGVGGGMGGRNLEAPHEPTDEDEQPLVCMICE 925
            ...:.::|.||.:...:..|:|:                                    .|:||.
Human    36 CQDELAELDPGTISVSDDRAEQR------------------------------------TCLICG 64

  Fly   926 DKATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNRCQYCRFKKCIEQGMVLQA 990
            |:|||||||||:||||||||||::.|:|||.|..|..|.:::.|||||||||..||::.||..:|
Human    65 DRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKA 129

  Fly   991 VREDRMPGGRNS--GAVYNLYKVKYKKHKKTNQKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQH 1053
            :|||.||||||.  |.|                    |.::::.::..:.|:.:::
Human   130 IREDGMPGGRNKSIGPV--------------------QISEEEIERIMSGQEFEEE--------- 165

  Fly  1054 QQQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLSPQQQQLAAAVAAAAQHQQQQQQQQQQQQ 1118
                          ..|.|:|....|.   ||.:..|...|....:..::::..:
Human   166 --------------ANHWSNHGDSDHS---SPGNRASESNQPSPGSTLSSSRSVE---------- 203

  Fly  1119 QAKLMGGVVDMKPMFLGPALKPELLQAPPMHSPAQQQQQQQQQQQQQQASPHLSLSSPHQQQQQQ 1183
                :.|.:..:..::|       :..||.:                |..|||...|.|.....|
Human   204 ----LNGFMAFREQYMG-------MSVPPHY----------------QYIPHLFSYSGHSPLLPQ 241

  Fly  1184 QGQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTALTNPSEIVHLRHRLDSAVSSSKDRQISY 1248
            |.:                                                      |.|.| ||
Human   242 QAR------------------------------------------------------SLDPQ-SY 251

  Fly  1249 EHALGMIQTLIDCDAMEDIATLPHFSE--FLEDKSEISEKLCNIGDSIVHKLVSWTKKLPFYLEI 1311
                .:|..|:..:.:|.:.| |...|  :...::|:...||.:.|.::.:.::|.|||||:.|:
Human   252 ----SLIHQLLSAEDLEPLGT-PMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCEL 311

  Fly  1312 PVEIHTKLLTDKWHEILILTTAAYQALHGKRRGEGGGSRHGSPASTPLSTPTGTPLSTPIPSPA- 1375
            .::.:|.||:..|.|:::|::.   .::.|:       ..|..|..           |...||:
Human   312 SIKDYTCLLSSTWQELILLSSL---TVYSKQ-------IFGELADV-----------TAKYSPSD 355

  Fly  1376 QPLHKDDPEFVSEVNSHLSTLQTCLTTLMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKLKMEE 1440
            :.||:...|                        .||        :::::..:...|.::|:..||
Human   356 EELHRFSDE------------------------GME--------VIERLIYLYHKFHQLKVSNEE 388

  Fly  1441 YVCLKVYILLNK------AEVELESIQERYVQVLRSYLQNSSPQNPQARLSELLSHIPEIQAAAS 1499
            |.|:|....||:      :..:||.:.:||..:.:.:.:......|. |..:|:..:|||:..|
Human   389 YACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYKYTHQPN-RFPDLMMCLPEIRYIA- 451

  Fly  1500 LLLESKMFYVP 1510
                .||..||
Human   452 ----GKMVNVP 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr4	NP_001259161.1	NR_DBD_DHR4_like	913..1002	CDD:143542	52/88 (59%)
Hr4	NP_001259161.1	NR_LBD_DHR4_like	1256..1515	CDD:132751	57/264 (22%)
NR6A1	NP_201591.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		14/60 (23%)
		NR_DBD_GCNF_like	52..141	CDD:143543	54/124 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..150		12/38 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..199		8/62 (13%)
		Sufficient for interaction with UIMC1. /evidence=ECO:0000250	172..253		23/179 (13%)
		NR_LBD_DHR4_like	256..467	CDD:132751	57/263 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159480
Domainoid	1	1.000	108	1.000	Domainoid score	I6472
eggNOG	1	0.900	-	-		E33208_3B99I
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5991
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108526
Panther	1	1.100	-	-	LDO	PTHR48092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4605
SonicParanoid	1	1.000	-	-		X4570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.690