DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3587 and KTI12

DIOPT Version :9

Sequence 1:	NP_569965.1	Gene:	CG3587 / 31160	FlyBaseID:	FBgn0023521	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_012812.1	Gene:	KTI12 / 853750	SGDID:	S000001593	Length:	313	Species:	Saccharomyces cerevisiae

Alignment Length:	346	Identity:	101/346 - (29%)
Similarity:	157/346 - (45%)	Gaps:	86/346 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLVVITGLPASGKSTRARQLRDHFVERGRKVHLISENEAVPK-----------AGFG-KNSHTG 53
            ||||:.||.|.|||:|.|:    |.|:.     |.|:.:|.|.           ...| |:|...
Yeast     1 MPLVLFTGYPCSGKTTLAK----HLVQL-----LQSKIDATPSLSKYSITYHSDESLGIKHSDYI 56

  Fly    54 DSQKEKVVRSDLKSEASRHLNQEDLVILDAGNYIKGYRYELYCMSKVSRTTQCTVFTCIPQEEAW 118
            .||.|:.:||::.|...|.|::..:||:|:.|||||:||:|:|..|...||.|.:.|..|.|..:
Yeast    57 TSQDERKLRSEIISAVKRDLSKNKIVIVDSLNYIKGFRYQLHCEVKNLSTTFCVIQTLCPPETIF 121

  Fly   119 TFNSQRTAPDELPGDSERVQPVDNSDVPYTRETFDALCQRYEEPQSNNRWDSPLVVVL-PKDTLD 182
            .:| :.:.|:                 |:..|..:.|.||||||.|:|||||||..:| |:|.:.
Yeast   122 EWN-KTSNPN-----------------PWEPELLNQLIQRYEEPNSSNRWDSPLFAILTPQDNIT 168

  Fly   183 --MEAIYKALYE----------SQPL-----PPNQSTYNAPLGTTNYLFELDKIVQAIIKEILGA 230
              ::.|.|.:::          :.||     .||.:|...|...:|::..||.....|||.|:..
Yeast   169 DYIDDICKVVFQTSKSAKNSGHNDPLSKGLQKPNSATVLKPASQSNFIQVLDIETSKIIKTIMNH 233

  Fly   231 VKIKAFGQLRIPGSRNPVKVATS---------------------MNALQLNRLRQKFITSTCHAS 274
            :|    ....|.|..|..:|..|                     :...||.||:::||    :.:
Yeast   234 IK----SLTSIGGVSNGTRVIVSEGITDINDDGCFFVDLPIGNVVTLAQLQRLKRQFI----NFN 290

  Fly   275 QTSPTPLEQVPHLFVQFINAN 295
            :......:::..||..::|.|
Yeast   291 KLRDIDQDRIGPLFADYLNKN 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3587	NP_569965.1	KTI12	3..293	CDD:285611	97/340 (29%)
CG3587	NP_569965.1	NK	3..263	CDD:302627	92/310 (30%)
KTI12	NP_012812.1	KTI12	3..309	CDD:400643	97/340 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346209
Domainoid	1	1.000	112	1.000	Domainoid score	I1369
eggNOG	1	0.900	-	-		E1_COG4088
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6347
Inparanoid	1	1.050	114	1.000	Inparanoid score	I1350
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55163
OrthoFinder	1	1.000	-	-		FOG0005231
OrthoInspector	1	1.000	-	-		oto98954
orthoMCL	1	0.900	-	-		OOG6_103506
Panther	1	1.100	-	-	LDO	PTHR12435
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R646
SonicParanoid	1	1.000	-	-		X3752
TreeFam	1	0.960	-	-
	15	14.790