DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11596 and CARNMT1

DIOPT Version :9

Sequence 1:	NP_726779.1	Gene:	CG11596 / 31158	FlyBaseID:	FBgn0023522	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_689633.1	Gene:	CARNMT1 / 138199	HGNCID:	23435	Length:	409	Species:	Homo sapiens

Alignment Length:	373	Identity:	162/373 - (43%)
Similarity:	228/373 - (61%)	Gaps:	23/373 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EEEEEK----HIQKVQNAFLYYGPYACQRLKRSMDYLNSLSGEDQIMLAKYRGHLECVRTCIDRN 87
            |||||:    |..|:.|||.|||....:|:.|:.....||....|.:|.::..||:.:|.|||.|
Human    55 EEEEERLEREHFWKIINAFRYYGTSMHERVNRTERQFRSLPANQQKLLPQFLLHLDKIRKCIDHN 119

  Fly    88 QAVIREILRGRVLYPTDEATGDPSEFDEPPPNVRHGDMDQIDIPFDEADVEPLKILKAQSTLKLI 152
            |.::..|:...:....::..|:..          :|.:    :|....|::.||     ||||..
Human   120 QEILLTIVNDCIHMFENKEYGEDG----------NGKI----MPASTFDMDKLK-----STLKQF 165

  Fly   153 ARDWSTEGALEREQSYKPIIDSIVAYFKHSDFELKDIKILVPGAGLGRLTYELACLGYSCEGNEF 217
            .||||..|..||:..|:|||..|:..|....::...:.|||||||||||.:|:|.|||:|:|||:
Human   166 VRDWSETGKAERDACYQPIIKEILKNFPKERWDPSKVNILVPGAGLGRLAWEIAMLGYACQGNEW 230

  Fly   218 SYFMLIASNFVLNLCDNENKYVLYPWVHQYVNNLRREDQVAPVRFPDVCPLKNPPKGHFEIAAGD 282
            |:|||.:||||||.|...|||.||||:||:.||.|..||:.|:.||||.|...||..:|.:.|||
Human   231 SFFMLFSSNFVLNRCSEINKYKLYPWIHQFSNNRRSADQIRPIFFPDVDPHSLPPGSNFSMTAGD 295

  Fly   283 FLEVYKTPNAYNCVATCFFIDCANNVIDFIRTIYKILVPGGIWVNLGPLLYHFSDVSGQNSIEPA 347
            |.|:|...|.::|:|||||||.|:||||:|.||:|||.|||||:|||||||||.:::.:.|||.:
Human   296 FQEIYSECNTWDCIATCFFIDTAHNVIDYIDTIWKILKPGGIWINLGPLLYHFENLANELSIELS 360

  Fly   348 FEDLCIIMESVGFVIEKSRTGIRTKYAQNPSSMKQSEYQSLFWVCRKP 395
            :||:..::...||.:|..:..:.:.|..|..||.:..|:.:.:|.|||
Human   361 YEDIKNVVLQYGFKVEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKP 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11596	NP_726779.1	N2227	114..396	CDD:285218	133/282 (47%)
CARNMT1	NP_689633.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		N2227	144..409	CDD:285218	133/274 (49%)
		GXGXG motif (S-adenosyl-L-methionine-binding). /evidence=ECO:0000269\|PubMed:29463897	208..212		3/3 (100%)
		Carnosine-binding. /evidence=ECO:0000269\|PubMed:29463897	313..398		41/84 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147701
Domainoid	1	1.000	283	1.000	Domainoid score	I1652
eggNOG	1	0.900	-	-		E1_KOG2798
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6806
Inparanoid	1	1.050	322	1.000	Inparanoid score	I2516
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55992
OrthoDB	1	1.010	-	-		D1437030at2759
OrthoFinder	1	1.000	-	-		FOG0004251
OrthoInspector	1	1.000	-	-		oto90950
orthoMCL	1	0.900	-	-		OOG6_102486
Panther	1	1.100	-	-	LDO	PTHR12303
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1981
SonicParanoid	1	1.000	-	-		X2988
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800