DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and SYNJ2

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_003889.1	Gene:	SYNJ2 / 8871	HGNCID:	11504	Length:	1496	Species:	Homo sapiens

Alignment Length:	638	Identity:	169/638 - (26%)
Similarity:	258/638 - (40%)	Gaps:	177/638 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 VKQELKKRESEYIVYKDIIIYCATWNVNNKTCSDSN----NPLRAWLACS------------EKP 216
            :.:.:.:|:||:..:|.|.|...|||||......||    ..|..||..|            ..|
Human   513 ILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSP 577

  Fly   217 PDIYAIGLQEL-DTPTKAMLNSTQVQAIEKQWIDKMMDSVHPDVEYEILMSHRLVATMLTVIVRK 280
            .||:|:|.:|: :.....::|::...  :|.|.:::..::.....|.:|.|.:||...|.:.||.
Human   578 ADIFAVGFEEMVELSAGNIVNASTTN--KKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRP 640

  Fly   281 QLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVE 345
            .....|......:|..|:....||||.|.|..|.:..:.||:.|||.|....|:|||:||..|.:
Human   641 YHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQ 705

  Fly   346 GIRFDDGRTISDHDHIFWVGDLNYRIQEPPGQQRPGPLSDAQTYE------------LLLQYDQL 398
            .:.|..||.:..||::||.||.||||.              .|||            .||::|||
Human   706 KLCFPMGRNVFSHDYVFWCGDFNYRID--------------LTYEEVFYFVKRQDWKKLLEFDQL 756

  Fly   399 RQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRVLW--------------- 448
            :.:...||.|:.:.||.|.|.||||||.|:..||:|:|.|.||:.|||||
Human   757 QLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELN 821

  Fly   449 -------KGTRIEQ------LAYNSIMEIRQSDHKPVYAVFQVKVKTRDEVKYKRVQEEV----- 495
                   ..|::..      |.|....|::.|||:||.|:.:|:|:..|....:||.:||
Human   822 LLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQG 886

  Fly   496 -LKAV-----------DKRENDNQPQINVEKTVIDFGT---VRFNE--------PSTRDFNVYNN 537
             |.|.           :|.|.....:..:.:|:..:||   ||.|:        .|....:|
Human   887 PLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSV--- 948

  Fly   538 CPLPVDFSFKEK----DIHAICEPWL-----HVDPRQDSL--LIDSARSIRLKMNANVRTIAGLL 591
              |.|| ..|.|    .|....:.||     .:..::||:  :..:|.|..|:
Human   949 --LDVD-GMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLE------------ 998

  Fly   592 RKIRASDNFDILILHVENGRDIFITVTGDY------QPSCFGLSMETMCRTDRPLSEYSQDQIKQ 650
                  :|||...|..|:..|| :....||      ||   |:|.          ||...|.:..
Human   999 ------ENFDFTSLDYESEGDI-LEDDEDYLVDEFNQP---GVSD----------SELGGDDLSD 1043

  Fly   651 L----------------MNDESPEYR-----VTMPREFFLLIDYLYRQGSKQV 682
            :                ...:.|.|:     |.:.||...:.::.:|..|:.:
Human  1044 VPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSL 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	110/349 (32%)
		RhoGAP_OCRL1	614..823	CDD:239845	16/96 (17%)
SYNJ2	NP_003889.1	Syja_N	61..342	CDD:280532
		EEP	530..861	CDD:294334	109/346 (32%)
		DUF1866	872..1008	CDD:286093	33/159 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1073		9/58 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1085..1166		2/12 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1405
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1427..1473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810