DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ocrl and SYNJ1

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_003886.3	Gene:	SYNJ1 / 8867	HGNCID:	11503	Length:	1612	Species:	Homo sapiens

Alignment Length:	786	Identity:	196/786 - (24%)
Similarity:	295/786 - (37%)	Gaps:	247/786 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RFKEDETIEYIFEA-YQIKGPEYSNRLLALVSSQSGGTFAIIAFSYLRTPLSSANELIINKVF-- 88
            ||:|      :|.: :.:.|..        :|....||.|:...:.|:....|....|.|..|
Human   459 RFQE------VFRSMWSVNGDS--------ISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDS 509

  Fly    89 ----AID-------HNFQLRQDSKSSITTQQFDLSTAEDGPIKYYYYATESHHYEEFVAKVISFK 142
                |||       .|..|...:::.:||....:|                             :
Human   510 SKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVS-----------------------------E 545

  Fly   143 STMAQHDPETVLNFRWLNDYRQIGEVKQELKKRESEYIVYKDIIIYCATWNVNN----KTCSDSN 203
            .|: |.....||.....|.|:               |...|.|.:...|||||.    ::.:..|
Human   546 QTL-QSASSKVLKSMCENFYK---------------YSKPKKIRVCVGTWNVNGGKQFRSIAFKN 594

  Fly   204 NPLRAWLACS-------------EKPPDIYAIGLQELDTPTKAMLNSTQVQAI----EKQWIDKM 251
            ..|..||..:             .||.||:|||.:|:     ..||:..:.:.    :|.|..::
Human   595 QTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEM-----VELNAGNIVSASTTNQKLWAVEL 654

  Fly   252 MDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQLNE 316
            ..::..|.:|.:|.|.:||...|.|.:|.|....|......:|..|:....||||.|||.:..:.
Human   655 QKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHT 719

  Fly   317 GNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRTISDHDHIFWVGDLNYRIQEPPGQQRPG 381
            .::|||.||.||....|:|||:|:..|...:.|..||.:..||::||.||.||||..|  .:...
Human   720 TSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLP--NEEVK 782

  Fly   382 PLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRV 446
            .|...|.::.|:..|||..:...|:.|.|:.||::.|.||||||..:|:||:|||.|.||:.|||
Human   783 ELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRV 847

  Fly   447 LWK--------------------------------GTRIEQLAYNSIMEIRQSDHKPVYA----- 474
            ||:                                ||    |.:....|::.|||:||.|
Human   848 LWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGT----LLHYGRAELKTSDHRPVVALIDID 908

  Fly   475 VFQVKVKTRDEVKYKRVQEEVLKAVDKRENDNQPQINVEKTVIDFGTVRFNEPSTRDFNVYNNCP 539
            :|:|:.:.|..: ||    ||:..      ...|.          |||..:..|:
Human   909 IFEVEAEERQNI-YK----EVIAV------QGPPD----------GTVLVSIKSS---------- 942

  Fly   540 LPVDFSFKEKDIHAICEPWLHVDPRQDSLLIDSARSIRLKMNANVRTIAGLLRKIRASDNFDILI 604
            ||.:..|                   |..|||.                 ||::. ||....|||
Human   943 LPENNFF-------------------DDALIDE-----------------LLQQF-ASFGEVILI 970

  Fly   605 LHVENGRDIFIT-VTGDYQPSCFGLSMETMCRTDRPLSEYSQDQIKQLMNDESPEYRVTMPREFF 668
            ..||:  .:::| :.|....:...|:.:.:......::..|.|.||.|..:.|.| ::::
Human   971 RFVED--KMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNLEEEMSLE-KISI----- 1027

  Fly   669 LLIDYLYRQGSKQVGAFPSYDSRLSLGAQFNSVRDWLDTWSD-DPFPANAETAAQALLLLLDLPE 732
                           |.||..|...||.......|: |...| |.:.|..|..         ||:
Human  1028 ---------------ALPSSTSSTLLGEDAEVAADF-DMEGDVDDYSAEVEEL---------LPQ 1067

  Fly   733 HALLEP 738
            |  |:|
Human  1068 H--LQP 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	27/149 (18%)
		INPP5c_INPP5B	185..478	CDD:197327	112/350 (32%)
		RhoGAP_OCRL1	614..823	CDD:239845	27/127 (21%)
SYNJ1	NP_003886.3	Syja_N	99..379	CDD:280532
		INPP5c_Synj1	572..907	CDD:197332	111/345 (32%)
		DUF1866	906..1047	CDD:286093	44/231 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810