DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and INP52

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_014293.1	Gene:	INP52 / 855618	SGDID:	S000005050	Length:	1183	Species:	Saccharomyces cerevisiae

Alignment Length:	565	Identity:	163/565 - (28%)
Similarity:	255/565 - (45%)	Gaps:	97/565 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ATRTTKDIVKERFKED----------------------ETIEYIFEAYQIKGPEYSNRLL----- 53
            :|::::..:..|:||.                      ||.:..|.|.....|:..|.:|
Yeast   361 STKSSEIQLSRRYKEQLKNSEKMKIGRDVFLTSFDFHRETSQDGFAAASRIIPKIRNTILDAGYF 425

  Fly    54 -------ALVSSQSGGTFAIIAFSYL-RTPL-SSANELIINKVFAIDHNFQLRQDSKSSITTQQF 109
                   .|:|.|. |.|.......| ||.| .....|.:.|:|..|  |:|.:.| |.|...:|
Yeast   426 SYDVKEGRLISEQD-GVFRTNCLDCLDRTNLIQQTISLAVFKLFLED--FRLVKPS-SFIDDNEF 486

  Fly   110 ----DLSTAEDG-PIKYYYYATESHHYEEFVAKVISFKSTMAQHDPETVLNFRWLNDY------- 162
                :...|::| .|...|..|.:..........:||...::  |....::..::|::
Yeast   487 VQKVNALWADNGDQISQIYTGTNALKSSYSRKGKMSFSGALS--DATKSVSRMYINNFVDKGKQQ 549

  Fly   163 -----------RQIGE--------VKQELKKRESEYIVYKDIIIYCATWNVN-NKTCSDSNNPLR 207
                       :|:.|        |.:.|.:.|.::..:.:|.::..|:||| |...:|    |.
Yeast   550 NIDTLLGKLPHQQVVELYDPICEYVNERLLESEEKFTTHSNINLFVGTFNVNGNSRRAD----LS 610

  Fly   208 AWL-ACSEK-PPDIYAIGLQE-LDTPTKAMLNSTQVQAIEKQWIDKMMDSVHP-DVEYEILMSHR 268
            .|| ...:| .||:..:|||| ::....::||:...::  ..|...:.|.::. :.:|.:|...:
Yeast   611 KWLFPIGDKFKPDVVVLGLQEVIELTAGSILNADYTKS--SFWETMVTDCLNQYEEKYLLLRVEQ 673

  Fly   269 LVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYV 333
            :.:.::....|.....:|......:...|.....||||.|||.......:.||||:||:|....:
Yeast   674 MSSLLILFFARSDRAYNIKEVGGSTKKTGFGGITGNKGAVAIRFDYGATSFCFVNTHLSAGASNI 738

  Fly   334 EERNQDYNAIVEGIRFDDGRTISDHDHIFWVGDLNYRIQEPPGQQRPGPLSDAQTY-ELLLQYDQ 397
            :||..|||.|...|.|...:||..||.:||:|||||||.....:.|....:....| :.||||||
Yeast   739 DERRNDYNNIYRNITFPRSKTIPHHDSLFWLGDLNYRITLTNDEVRRELRAQKDGYIDRLLQYDQ 803

  Fly   398 LRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRVLWKGTRIEQLAYNSIM 462
            |.||:..|..|:|:.|..::||||||||.||||||:|||.|.|::.||:::||..:..||| |..
Yeast   804 LTQEINEGVVFQGFKEPTLQFRPTYKYDYGTDNYDTSEKARTPSWTDRIIYKGENLHPLAY-SDA 867

  Fly   463 EIRQSDHKPVYAVFQVKVKTRDE-----------VKYKRVQEEVL 496
            .::.||||||||.::..||..||           .:||....|.|
Yeast   868 PLKISDHKPVYAAYRANVKFVDEKEKLNLVEKLYAEYKNTHPEAL 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	38/198 (19%)
		INPP5c_INPP5B	185..478	CDD:197327	111/298 (37%)
		RhoGAP_OCRL1	614..823	CDD:239845
INP52	NP_014293.1	COG5329	1..628	CDD:227637	57/276 (21%)
		COG5411	564..1052	CDD:227698	123/356 (35%)
		Aim21	<978..1166	CDD:371558
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810