DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and INP51

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_012264.3	Gene:	INP51 / 854815	SGDID:	S000001264	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	543	Identity:	153/543 - (28%)
Similarity:	247/543 - (45%)	Gaps:	94/543 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DIVKERFKEDETIEYIF------EAYQIKGPEYS--------NRLLALVS--------------- 57
            :|:|.:.:..|.:...:      :..:|...|||        ::||.|:.
Yeast   345 NIIKPKSESQEKLALTYKDCAESKGIKITNIEYSSSVLTKSPHKLLYLLKQDIYEFGAFAYDISR 409

  Fly    58 ----SQSGGTFAIIAFSYLRTPLSSANELIINKVFAIDHN----FQLRQ---DSKSSITTQQFDL 111
                ::..|...|.||..:..| ::...|:..:|..:..|    |:|..   |:...:.::.:
Yeast   410 GIYFAKQTGVLRISAFDSIEKP-NTVERLVSKEVLELTTNEIDVFELTSPFLDAHDKLWSENY-- 471

  Fly   112 STAEDGPIKYYYYATESHH------YEEFVAKVISFKSTMAQHDPETVLNFRWLNDYRQIGEVKQ 170
                     |:...|.:.|      |.:..:|:  |.|.:..:||        |:.|     :.|
Yeast   472 ---------YWLDRTYTKHTKNSGKYTKVYSKL--FGSRVRLYDP--------LHIY-----ISQ 512

  Fly   171 ELKKRESEYIVYKDIIIYCATWNVNNKTCSDSNNPLRAW-----LACSEKPPDIYAIGLQELD-- 228
            .||:..|:|...|||.|:..|:|::.|...|.   ::.|     ::..::..|:|.|||:|:.
Yeast   513 YLKQLRSKYTFEKDISIFAGTFNISGKIPKDD---IKDWIFPKSMSKEDEMADLYVIGLEEVVEL 574

  Fly   229 TPTKAMLNSTQVQAIEKQWIDKMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKS 293
            ||...:.....|:...::.|..:::......:|..|.|.:|...:|.:.:.:.....:.......
Yeast   575 TPGHMLATDPYVRQFWEKKILTLLNGPGRKKKYIRLWSTQLGGILLLLFMNETEYSKVKHIEGDV 639

  Fly   294 VARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRTISDH 358
            ...|......|||.||:|.:.:....|.:.|||||.:..||:|:.||..|.:.|||..|..|.||
Yeast   640 KKTGFGGMASNKGAVAVSFKYSATRFCVLVSHLAAGLENVEQRHNDYKTIAKSIRFSKGLRIKDH 704

  Fly   359 DHIFWVGDLNYRIQEPPGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYK 423
            |.|.|:||.||||.......|...:|  :.|..|.:.|||.|:|..|:.|..:.|..|.|.||||
Yeast   705 DAIIWMGDFNYRILMSNEDVRRKIVS--KEYASLFEKDQLNQQMIAGESFPYFHEMAIDFPPTYK 767

  Fly   424 YDPGTDNYDSSEKQRAPAYCDRVLWKGTRIEQLAYNSIMEIRQSDHKPVYAVFQVKVKTRDEVK- 487
            :||||.|||:|||.|.||:.||:|.:|..:|||.|....:|..|||:||||:|:.:|...||.|
Yeast   768 FDPGTKNYDTSEKMRIPAWTDRILSRGEVLEQLEYKCCEDILFSDHRPVYAIFRARVTVVDEQKK 832

  Fly   488 -------YKRVQEEVLKAVDKRE 503
                   |:::.|. |:.:|..|
Yeast   833 TTLGTQIYEKIMER-LEGLDDDE 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	31/185 (17%)
		INPP5c_INPP5B	185..478	CDD:197327	105/299 (35%)
		RhoGAP_OCRL1	614..823	CDD:239845
INP51	NP_012264.3	COG5329	1..501	CDD:227637	28/169 (17%)
INP51	NP_012264.3	COG5411	498..946	CDD:227698	126/376 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3488
SonicParanoid	1	1.000	-	-		X494
TreeFam	0	0.000	Not matched by this tool.
	4	3.840