DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and INP53

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_014752.3	Gene:	INP53 / 854276	SGDID:	S000005635	Length:	1107	Species:	Saccharomyces cerevisiae

Alignment Length:	570	Identity:	164/570 - (28%)
Similarity:	260/570 - (45%)	Gaps:	88/570 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 IIAFSYLRT-----PLSSANELIINKVFA-------IDHNFQLRQ------DSKSSITTQ----- 107
            ||:.:..||     .|.|:|..|.:..|.       .||..|:.|      ..|||.:.:
Yeast   434 IISLAAFRTFLEDFRLISSNSFIDDDDFVSKHNTLWADHGDQISQIYTGTNALKSSFSRKGKMSL 498

  Fly   108 QFDLSTAEDGPIKYY---YYATESHHYEEFVAKVISFKSTMAQHDPETVLNFRWLNDYRQIGEVK 169
            ...||.|.....:.|   :...|.....:.:...:.::..:..:||        :|:|     |.
Yeast   499 AGALSDATKSVSRIYINNFMDKEKQQNIDTLLGRLPYQKAVQLYDP--------VNEY-----VS 550

  Fly   170 QELKKRESEYIVYKDIIIYCATWNVNNKTCSDSNNPLRAWL-ACSEK-PPDIYAIGLQE-LDTPT 231
            .:|:....::....:|.:...::|||..|   ....|..|| ...|| .|||..:|||| ::...
Yeast   551 TKLQSMSDKFTSTSNINLLIGSFNVNGAT---KKVDLSKWLFPIGEKFKPDIVVLGLQEVIELSA 612

  Fly   232 KAMLNSTQVQAIEKQWIDKMMDSVHP-DVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVA 295
            .::||:...::  ..|.:.:.|.::. |.:|.:|...::.:.::...|:....:::.:....:..
Yeast   613 GSILNADYSKS--SFWENLVGDCLNQYDDKYLLLRVEQMTSLLILFFVKADKAKYVKQVEGATKK 675

  Fly   296 RGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRTISDHDH 360
            .|.....||||.|:|..:....:.|||||||||....||||..||.:||.||.|...:.|..||.
Yeast   676 TGFRGMAGNKGAVSIRFEYGATSFCFVNSHLAAGATNVEERRSDYESIVRGITFTRTKMIPHHDS 740

  Fly   361 IFWVGDLNYRIQEPPGQQRPGPLSDAQTY-ELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKY 424
            |||:||:||||..|....|...|:..:.| :.||.:|||...:..|..|||:.|..:||||||||
Yeast   741 IFWLGDMNYRINLPNEDVRRELLNQEEGYIDKLLHFDQLTLGINSGSVFEGFKEPTLKFRPTYKY 805

  Fly   425 DPGTDNYDSSEKQRAPAYCDRVLWKGTRIEQLAYNSIMEIRQSDHKPVYAVFQVKV-----KTRD 484
            ||||..||||||:|.|::.||:::||..:..|:| |...|..|||:||||.::.|:     |.|.
Yeast   806 DPGTGTYDSSEKERTPSWTDRIIYKGENLLPLSY-SDAPIMISDHRPVYAAYRAKITFVDDKERL 869

  Fly   485 EVKYKRVQEEVLKAVDKRENDNQPQINVEKTVIDFGTVRFNEPSTRDFNVYNNCPLPVDFSFKEK 549
            .:| ||:..|.     |:|:..:|    ...:.|..::..:..||..|.           |..|.
Yeast   870 SLK-KRLFTEY-----KQEHPEEP----GSLISDLLSLDLDNKSTDGFK-----------SSSES 913

  Fly   550 DIHAICEPWLHVDPRQDSLLIDSARSIRLKMNANVRTIAGLLRKIRASDN 599
            .:       |.:||........|..|     ::.|.:.:..|:.:|..::
Yeast   914 SL-------LDIDPIMAQPTASSVAS-----SSPVSSASASLQPVRTQNS 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	24/122 (20%)
		INPP5c_INPP5B	185..478	CDD:197327	113/297 (38%)
		RhoGAP_OCRL1	614..823	CDD:239845
INP53	NP_014752.3	COG5329	1..603	CDD:227637	40/184 (22%)
INP53	NP_014752.3	INPP5c_ScInp51p-like	566..858	CDD:197324	113/297 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810