Protein Alignment Ocrl and INP53

DIOPT Version :10

• Sequence 1: NP_569962.2
• Gene: Ocrl / 31157
• FlyBaseID: FBgn0023508
• Length: 850
• Species: Drosophila melanogaster
• Sequence 2: NP_014752.3
• Gene: INP53 / 854276
• SGDID: S000005635
• Length: 1107
• Species: Saccharomyces cerevisiae
• Alignment Length: 570
• Identity: 164/570 - (28%)
• Similarity: 260/570 - (45%)
• Gaps: 88/570 - (15%)

  Fly    66 IIAFSYLRT-----PLSSANELIINKVFA-------IDHNFQLRQ------DSKSSITTQ----- 107
            ||:.:..||     .|.|:|..|.:..|.       .||..|:.|      ..|||.:.:
Yeast   434 IISLAAFRTFLEDFRLISSNSFIDDDDFVSKHNTLWADHGDQISQIYTGTNALKSSFSRKGKMSL 498

  Fly   108 QFDLSTAEDGPIKYY---YYATESHHYEEFVAKVISFKSTMAQHDPETVLNFRWLNDYRQIGEVK 169
            ...||.|.....:.|   :...|.....:.:...:.::..:..:||        :|:|     |.
Yeast   499 AGALSDATKSVSRIYINNFMDKEKQQNIDTLLGRLPYQKAVQLYDP--------VNEY-----VS 550

  Fly   170 QELKKRESEYIVYKDIIIYCATWNVNNKTCSDSNNPLRAWL-ACSEK-PPDIYAIGLQE-LDTPT 231
            .:|:....::....:|.:...::|||..|   ....|..|| ...|| .|||..:|||| ::...
Yeast   551 TKLQSMSDKFTSTSNINLLIGSFNVNGAT---KKVDLSKWLFPIGEKFKPDIVVLGLQEVIELSA 612

  Fly   232 KAMLNSTQVQAIEKQWIDKMMDSVHP-DVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVA 295
            .::||:...::  ..|.:.:.|.::. |.:|.:|...::.:.::...|:....:::.:....:..
Yeast   613 GSILNADYSKS--SFWENLVGDCLNQYDDKYLLLRVEQMTSLLILFFVKADKAKYVKQVEGATKK 675

  Fly   296 RGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRTISDHDH 360
            .|.....||||.|:|..:....:.|||||||||....||||..||.:||.||.|...:.|..||.
Yeast   676 TGFRGMAGNKGAVSIRFEYGATSFCFVNSHLAAGATNVEERRSDYESIVRGITFTRTKMIPHHDS 740

  Fly   361 IFWVGDLNYRIQEPPGQQRPGPLSDAQTY-ELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKY 424
            |||:||:||||..|....|...|:..:.| :.||.:|||...:..|..|||:.|..:||||||||
Yeast   741 IFWLGDMNYRINLPNEDVRRELLNQEEGYIDKLLHFDQLTLGINSGSVFEGFKEPTLKFRPTYKY 805

  Fly   425 DPGTDNYDSSEKQRAPAYCDRVLWKGTRIEQLAYNSIMEIRQSDHKPVYAVFQVKV-----KTRD 484
            ||||..||||||:|.|::.||:::||..:..|:| |...|..|||:||||.::.|:     |.|.
Yeast   806 DPGTGTYDSSEKERTPSWTDRIIYKGENLLPLSY-SDAPIMISDHRPVYAAYRAKITFVDDKERL 869

  Fly   485 EVKYKRVQEEVLKAVDKRENDNQPQINVEKTVIDFGTVRFNEPSTRDFNVYNNCPLPVDFSFKEK 549
            .:| ||:..|.     |:|:..:|    ...:.|..::..:..||..|.           |..|.
Yeast   870 SLK-KRLFTEY-----KQEHPEEP----GSLISDLLSLDLDNKSTDGFK-----------SSSES 913

  Fly   550 DIHAICEPWLHVDPRQDSLLIDSARSIRLKMNANVRTIAGLLRKIRASDN 599
            .:       |.:||........|..|     ::.|.:.:..|:.:|..::
Yeast   914 SL-------LDIDPIMAQPTASSVAS-----SSPVSSASASLQPVRTQNS 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_569962.2	INPP5B_PH	23..160	CDD:465268	23/119 (19%)
		INPP5c_INPP5B	185..478	CDD:197327	113/297 (38%)
		RhoGAP_OCRL1	614..823	CDD:239845
INP53	NP_014752.3	COG5329	1..603	CDD:227637	40/184 (22%)
		INPP5c_ScInp51p-like	566..858	CDD:197324	113/297 (38%)