DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ocrl and 5PTASE13

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_172054.3	Gene:	5PTASE13 / 837069	AraportID:	AT1G05630	Length:	1170	Species:	Arabidopsis thaliana

Alignment Length:	538	Identity:	129/538 - (23%)
Similarity:	219/538 - (40%)	Gaps:	146/538 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 VKQELKKRESEYIVYKDIIIYCATWNVNNKTCSDSNNPLRAWLACSEKPPDIYAIGLQELDTPTK 232
            ::.||.::|:.|....::.|...||||.....  |::.|.:||........|.|:||||::....
plant   554 IRTELSQKETLYARQDNVRILIGTWNVGQGRA--SHDALMSWLGSVTSDVGIVAVGLQEVEMGAG 616

  Fly   233 AMLNST-------QVQAIEKQWIDKMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCR 290
            .:..|.       :..|:.:.|||.:..::.....:|.:.|.:|...::::..||.:|.|:....
plant   617 FLAMSAAKETVGLEGSAVGQWWIDAIGKALDEKNTFERMGSRQLAGLLISLWARKDIRTHVGDLD 681

  Fly   291 PKSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFDDGRTI 355
            ..:|..|....:||||||.:.:::.:..:||||.|||||:..|..||.|:|.|...:.|..|:.:
plant   682 VAAVPCGFGRAIGNKGGVGLRIRVYDRIMCFVNCHLAAHLEAVNRRNADFNHIFRLMVFSRGQNL 746

  Fly   356 SD-----------------HDHIFWV--------------------------------------- 364
            |:                 ..::||:
plant   747 SNAAAGMVPYLFLSCSLGFSTYLFWLLYSSGLPWALSLAAGVSTSAYTTKSNTIPSTGAEEIKSD 811

  Fly   365 ----------GDLNYRIQEPPGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFR 419
                      ||.|||:......:....:|. ::::.|.:.||||.||:.||.|:|..|..|.|.
plant   812 LAAADMVAFFGDFNYRLFGITYDEARDFISQ-RSFDWLRERDQLRAEMKVGKVFQGMREALITFP 875

  Fly   420 PTYKYD---PGTDNYDSSEKQRAPAYCDRVLWKGTRIEQ--------------LAYNSIMEIRQS 467
            ||||::   .|...|||.||:|.||:||||:::.|:...              :.|.:.|::.:|
plant   876 PTYKFERNRSGLGGYDSGEKKRIPAWCDRVIYRDTQSSPFSESNLQCPVVSSVIMYEACMDVTES 940

  Fly   468 DHKPVYAVFQV-------KVKTRDEVKYKRVQEEVLKAVDKRE-------NDNQPQINVEKTVID 518
            |||||...|..       .|:.::..|..|..|::|...:...       :.|...:..:.|||
plant   941 DHKPVRCKFHATIAHVDKSVRRQELGKIIRSNEKILSIFEDLRFVPETSVSTNNIVLQSQDTVI- 1004

  Fly   519 FGTVRFNEPSTR--------------------DFNVYNNCPLPVDFSFKEKDIHAICEPWLHVDP 563
             .|:..|.|:::                    |:|...:..||               .||.|.|
plant  1005 -LTITNNSPTSQAIFNILCGGQAVVKDDGEDADYNPRGSFGLP---------------RWLEVSP 1053

  Fly   564 RQDSLLIDSARSIRLKMN 581
            ...  :|:...|:.:|::
plant  1054 AAG--IINPEGSVDVKVH 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	102/382 (27%)
		RhoGAP_OCRL1	614..823	CDD:239845
5PTASE13	NP_172054.3	WD40	<164..374	CDD:225201
		WD40	207..>294	CDD:295369
		WD40 repeat	446..474	CDD:293791
		WD40 repeat	481..514	CDD:293791
		RAB3GAP2_N	491..>523	CDD:291327
		WD40 repeat	520..556	CDD:293791	0/1 (0%)
		INPP5c	571..951	CDD:197308	102/382 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101357
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.670