DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and BST1

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001318880.1	Gene:	BST1 / 836633	AraportID:	AT5G65090	Length:	529	Species:	Arabidopsis thaliana

Alignment Length:	528	Identity:	137/528 - (25%)
Similarity:	216/528 - (40%)	Gaps:	165/528 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 HHY---EEFVAKVISFKSTMAQHDPETVLNFRWLNDYRQIGEVK----------QELKKRESEYI 180
            |||   .:|..::.|.|.::..:....:        ::.:.|.|          ....:..:...
plant    12 HHYGVFNDFERRMTSRKKSVLDNTSPMI--------WKTVSERKSSPGIEGLNLSSFDRPMAPTT 68

  Fly   181 VYKDIIIYCATWNVNNKT---------------------CS---------------DSNNPLRAW 209
            ..:::.::.|||||..:|                     |.               :.|.|...|
plant    69 EIRELRVFLATWNVGGRTPNNDLNLEDFLLVEGTADLYICGFQEIVPLSAGNVLVVEDNEPAAKW 133

  Fly   210 LAC------SEKPPDIY----------------AIGLQELDTPT--------------------K 232
            ||.      ..|...:|                :.|.:|...|:                    .
plant   134 LALISQALNKPKQESVYSNAAYSASRTTTCSSSSCGSEESRAPSSLSFFQRPNLKVLSRNYRVDS 198

  Fly   233 AMLNSTQVQAIE----------KQWIDKMMDS---VHPD----------------------VEYE 262
            ::|.:.....|:          |::.|...||   |.|:                      :.|.
plant   199 SLLKTCNCPVIDTSVGWEARRSKRFSDPSTDSSNNVEPENFRVHENFLFDDVPATTKMPGQMSYR 263

  Fly   263 ILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLA 327
            ::.|.::|...|:|..|::|..||...|..||.|||...|||||.:|||:.|::.:.|||.||||
plant   264 LIASKQMVGLFLSVWARRELIPHISHLRLDSVGRGIMGRLGNKGCIAISMSLHQTSFCFVCSHLA 328

  Fly   328 AHMGYVEE--RNQDYNAIVEGIRFDD---------GRTISDHDHIFWVGDLNYRIQEPPGQQRPG 381
            :.....:|  ||.|...|::..:|..         ...|.|||.:.|:||||||:.....:.|
plant   329 SGEKEGDELRRNADVAEILKHTQFPKLTKNPNCHAPERIIDHDRVLWLGDLNYRVALTYEETR-- 391

  Fly   382 PLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNY-----DSSEKQRAPA 441
            .|.:...::.||:.|||..|...|:.|.|:.||:|.|.|||||...:|.|     .|.:|:|.||
plant   392 VLLEDNDWDTLLERDQLNMERGAGRVFSGFQEGQIFFAPTYKYSQNSDAYAGEMTKSKKKRRTPA 456

  Fly   442 YCDRVLWKGTRIEQLAYNSIMEIRQSDHKPVYAVF--QVKVKTRDEVKYK--------RVQEEVL 496
            :|||:||||..||||:|.. .|.|.|||:||.|:|  :|.||:.::.:::        |:.|:|
plant   457 WCDRILWKGEGIEQLSYIR-GESRFSDHRPVCAIFAVEVDVKSLNKGRFRKGYSCAAVRLVEDV- 519

  Fly   497 KAVDKREN 504
             |:.:|.:
plant   520 -AIPQRHS 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	6/36 (17%)
		INPP5c_INPP5B	185..478	CDD:197327	121/423 (29%)
		RhoGAP_OCRL1	614..823	CDD:239845
BST1	NP_001318880.1	EEP	71..496	CDD:382041	122/427 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1399831at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2994
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820