DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and 5PTase12

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001323432.1	Gene:	5PTase12 / 818994	AraportID:	AT2G43900	Length:	1348	Species:	Arabidopsis thaliana

Alignment Length:	607	Identity:	148/607 - (24%)
Similarity:	250/607 - (41%)	Gaps:	141/607 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 GEVKQELKKRESEYIVYKDIIIYCATWNVNNKTCSDSNNPLRAWLACSEKPPDIYAIGLQELD-- 228
            |.::.||.::|..|.....:.|...:|||.....  |::.|.:||........|..:||||::
plant   557 GIIRSELAEKERTYAQTDSVRILTGSWNVGQGKA--SHDALMSWLGSVASDVGILVVGLQEVEMG 619

  Fly   229 ------TPTKAMLNSTQVQAIEKQWIDKMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHII 287
                  :..|..:...:...|.:.|||.:..::.....:|.:.|.:|...::::.|||.||.|:.
plant   620 AGFLAMSAAKESVGGNEGSTIGQYWIDTIGKTLDEKAVFERMGSRQLAGLLISLWVRKNLRTHVG 684

  Fly   288 RCRPKSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRF--- 349
            .....:|..|....:||||||.:.:::.:..:||:|.|||||:..|..||.|::.|.:.:.|
plant   685 DIDVAAVPCGFGRAIGNKGGVGLRIRVFDRIMCFINCHLAAHLEAVNRRNADFDHIYKTMSFTRS 749

  Fly   350 -----------------------------DDGRTISDHDHIFWVGDLNYRIQEPPGQQRPGPLSD 385
                                         :..:.:::.|.:.:.||.|||:......:....:|.
plant   750 SNAHNAPAAGVSTGSHTTKSANNANVNTEETKQDLAEADMVVFFGDFNYRLFGISYDEARDFVSQ 814

  Fly   386 AQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYD---PGTDNYDSSEKQRAPAYCDRVL 447
             ::::.|.:.||||.||:.|:.|:|..|..|.|.||||::   ||...|||.||:|.||:||||:
plant   815 -RSFDWLREKDQLRAEMKAGRVFQGMREAIITFPPTYKFERHRPGLGGYDSGEKKRIPAWCDRVI 878

  Fly   448 WKGTRIEQ--------------LAYNSIMEIRQSDHKPVYAVFQVKVKTRDEVKYKRVQEEVLKA 498
            ::.||...              :.|::.|::.:||||||...|.||::..|....::....::|.
plant   879 FRDTRTSPESECSLDCPVVASIMLYDACMDVTESDHKPVRCKFHVKIEHVDRSVRRQEFGRIIKT 943

  Fly   499 VDKRE---NDNQPQINVEKTVIDFGTVRFNEPSTRDFNVYNNCPLPVDFSFKEKDIHAI-CE--- 556
            .:|..   ||.:   .|.:|::...::......|....:.|.|       .||..:..| ||
plant   944 NEKVRALLNDLR---YVPETIVSSNSIVLQNQDTFVLRITNKC-------VKENAVFRILCEGQS 998

  Fly   557 --------------------PWLHVDPRQDSLLIDSARSIRLKMNA---------NVRTIAGLLR 592
                                .||.|...:.|:|..::...||.|..         .|...||
plant   999 TVREDEDTLELHPLGSFGFPRWLEVSKLKRSILSHNSLKTRLVMMTRSSSFFLFFQVMPAAG--- 1060

  Fly   593 KIRASDNFDILILH------------------VENGRD----IFITVTGDYQPSCFGLSMETMCR 635
            .|:...:.::.:.|                  .|:.||    :.:.|.|       |.|.||:|.
plant  1061 TIKPDSSVEVSVHHEEFHTLEEFVDGIPQNWWCEDTRDKEAILVVNVQG-------GCSTETVCH 1118

  Fly   636 TDRPLSEYSQDQIKQLMNDESP 657
            .......:|   .|.|..|.:|
plant  1119 RVHVRHCFS---AKNLRIDSNP 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622
		INPP5c_INPP5B	185..478	CDD:197327	98/349 (28%)
		RhoGAP_OCRL1	614..823	CDD:239845	12/44 (27%)
5PTase12	NP_001323432.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101357
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.670