DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and CVL1

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001189654.1	Gene:	CVL1 / 817761	AraportID:	AT2G32010	Length:	594	Species:	Arabidopsis thaliana

Alignment Length:	609	Identity:	143/609 - (23%)
Similarity:	229/609 - (37%)	Gaps:	230/609 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LRQDSKSSITTQQFDLSTAEDGPIKYYYYATESHHYEEFVAKV-------ISFKSTMAQHDPETV 153
            :|.|.     |::..||.::....|::...:::   |:|.|.|       :..:::.::.:|.|:
plant     1 MRDDK-----TKKSKLSWSKKMVRKWFNIKSKT---EKFQADVSLPQGVEVEHRNSFSEREPCTI 57

  Fly   154 -------LNFRWLNDYRQIGEVKQELKKRESEY-----IVYKDIIIYCATWNVNNKTCSDSNNPL 206
                   ||..|          :|:.::|:..|     |..::..|:.|||||..::..:..| |
plant    58 KKSKTEKLNKNW----------EQQARQRKMNYENPRIIDVQNHSIFVATWNVAGRSPPEDLN-L 111

  Fly   207 RAWLACSEKPPDIYAIGLQELDTPTKAMLNSTQVQAIE-----KQW------------------- 247
            ..||. |..|.|||.:|.||:     ..||:..|...|     |:|
plant   112 DEWLH-SSAPADIYVLGFQEI-----VPLNAGNVLGAEDNGPAKKWHSLIRKTLNNLPGASSACH 170

  Fly   248 -----------------------------------------------------------IDKMMD 253
                                                                       .|::..
plant   171 TPSPIPVPIAEIDADFSGSSRQKNETFFNRRSFQTPSVWSMEENDPSISQPRLDRRFSVCDRVFF 235

  Fly   254 SVHP----------------------------------------DV------------------- 259
            |..|                                        ||
plant   236 SHRPSDFDPSFRCGHRPSDYSRRPSDYSRPSDYYSRPSNYSRPSDVSRWGSSDDDNGPGDSPSTF 300

  Fly   260 ------------------------EYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFN 300
                                    :|.::.|.::|...||:.|:.:||:|:...:...|.||:..
plant   301 LNSPGSFLGSAANENGYRTPWNSSQYCLVASKQMVGIFLTIWVKSELREHVKNMKVSCVGRGLMG 365

  Fly   301 TLGNKGGVAISLQLNEGNICFVNSHLAAHMGYVEE--RNQDYNAIVEGIRFDDGRTISD------ 357
            .|||||.::||:.|::.:.|||.:||.:.....:|  ||.|...|::..||...::.:|
plant   366 YLGNKGSISISMLLHQTSFCFVCTHLTSGQKEGDELRRNSDVMEILKKTRFPRVQSSADEKSPEN 430

  Fly   358 ---HDHIFWVGDLNYRIQEPPGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFR 419
               ||.:.|:|||||||  ....:....|.:.|.:..||:.||||.|.:||..|:|:.||:|.|.
plant   431 ILQHDRVIWLGDLNYRI--ALSYRSAKALVEMQNWRALLENDQLRIEQKRGHVFKGWNEGKIYFP 493

  Fly   420 PTYKYDPGTDNY-----DSSEKQRAPAYCDRVLWKGTRIEQLAYNSIMEIRQSDHKPVYAVFQVK 479
            |||||...:|.|     ...||:|.||:|||:||.|..:.||:|.. .|.|.|||:|||.:|..:
plant   494 PTYKYSNNSDRYAGGDLHPKEKRRTPAWCDRILWHGEGLHQLSYVR-GESRFSDHRPVYGIFSAE 557

  Fly   480 VKTRDEVKYKRVQEEVLKAVDKRE 503
            |::..: :.||........|:..|
plant   558 VESNHK-RSKRTNSHSTARVEAEE 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	15/80 (19%)
		INPP5c_INPP5B	185..478	CDD:197327	119/474 (25%)
		RhoGAP_OCRL1	614..823	CDD:239845
CVL1	NP_001189654.1	EEP	17..582	CDD:412407	138/588 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1399831at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2994
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820