DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ocrl and ocrl

DIOPT Version :9

Sequence 1:	NP_001259153.1	Gene:	Ocrl / 31157	FlyBaseID:	FBgn0023508	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	XP_009289414.1	Gene:	ocrl / 777716	ZFINID:	ZDB-GENE-061110-61	Length:	961	Species:	Danio rerio

Alignment Length:	839	Identity:	258/839 - (30%)
Similarity:	416/839 - (49%)	Gaps:	117/839 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SEAVANGTATAATRTTKDIVKERFKEDETIEYIFEAYQIKGPEYSNRLLAL----------VSSQ 59
            :..:||.:.|.:||:    :...|..:|...::.:..:.|..:  |||:|.          :..:
Zfish   164 NSTLANPSNTDSTRS----LATDFGFEENFNHVLKVEEKKNKQ--NRLVAQREPPPPPIPPLPPR 222

  Fly    60 SGGTFAIIAFSYLRTPLSSANELIINKVF-AIDHNFQLRQDSKSSITTQQFDLST---AEDGPIK 120
            .|...::...:....|.|..|...:...| ::|.:... .:|.|:.|.:|..:|:   :.:|.:|
Zfish   223 KGTNTSLTGPATKERPPSVQNATPVRNEFQSVDRSVSW-SESPSNSTIRQAMMSSHAGSREGLLK 286

  Fly   121 YYYYATESHHYEEFVAKVISFKSTMAQHDPETVLNFRWLNDYRQIGEVKQELKKRESEYIVYKDI 185
            |                                                 .|.|:|.||:..|:.
Zfish   287 Y-------------------------------------------------RLSKKEKEYVDIKNF 302

  Fly   186 IIYCATWNVNNKTCSDSNNPLRAWLACSEKPPDIYAIGLQELDTPTKAM--LNSTQVQAIEKQWI 248
            ..:..|||||.::...|..|   ||:....|||:||:|.||||..|:|.  ::|::    |:.|:
Zfish   303 KFFVGTWNVNGQSPDSSLGP---WLSSDPDPPDVYALGFQELDLSTEAFFYMDSSK----EQLWV 360

  Fly   249 DKMMDSVHPDVEYEILMSHRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQ 313
            |.:...:|....|..:...|||..||.|.::|:.:..|.....:||..|:.|.:|||||||:...
Zfish   361 DAVERGLHQKARYIQVRIIRLVGMMLVVYIKKEHKDQIREIASESVGTGLMNKMGNKGGVAVRFV 425

  Fly   314 LNEGNICFVNSHLAAHMGYVEERNQDYNAIVEGIRFD----DGRTISDHDHIFWVGDLNYRIQEP 374
            .:..:.||||||||||:...|.|||||..|...:.|.    ...:|..||.:.|:||||||:..|
Zfish   426 FHNTSFCFVNSHLAAHVDDFERRNQDYKDICARMSFHLLEYPPVSIVKHDVVIWLGDLNYRLCLP 490

  Fly   375 PGQQRPGPLSDAQTYELLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRA 439
            ...:....:::.: ...|.:||||..:.:..:.|..:.||||.|.||||||..:|.:|||.|.|.
Zfish   491 DAGEVKRLIAEKE-LRRLQEYDQLNLQRKTKRVFTDFMEGEINFIPTYKYDAKSDRWDSSGKCRI 554

  Fly   440 PAYCDRVLWKGTRIEQLAYNSIMEIRQSDHKPVYAVFQVKVKTRDEVKYKRVQEEVLKAVDKREN 504
            ||:|||:||:|:.::||.|.|.||::.||||||.:||.:.||...|.:||::.||:::.:|:.||
Zfish   555 PAWCDRILWRGSNVKQLHYRSHMELKTSDHKPVSSVFSIGVKMVIEQRYKKIFEEIVRDMDRMEN 619

  Fly   505 DNQPQINVEKTVIDFGTVRFNEPSTRDFNVYNNCPLPVDFSFKEK-DIHAICEPWLHVDPRQDSL 568
            |..|.:::.:....|..|:|.:...:.|.:.|:..:...|:|..| :....|:|||..:|.:.
Zfish   620 DFLPSLSLTRREFTFENVKFRQLQRQSFLITNDGQVACTFAFIPKLNDSQYCKPWLRAEPCEG-- 682

  Fly   569 LIDSARSIRLKMNANV-RTIAGLLRKIRASDNF-DILILHVENGRDIFITVTGDYQPSCFGLSME 631
            ::|....|.:.:...| :....||..  ..||. |||:||::.|:|.||||:|:|.|||||.|:|
Zfish   683 VLDPNEKIEIFLEVYVSKDSVTLLNS--GEDNIEDILVLHLDRGKDYFITVSGNYLPSCFGTSLE 745

  Fly   632 TMCRTDRPLSEYSQDQIKQLMND---ESPEYRVT--------------MPREFFLLIDYLYRQGS 679
            |:||..:|:.|....::..|..|   |..:.|:|              :|:|.:||:::||.:..
Zfish   746 TLCRMKKPIREIPITKLIDLGEDSCMEKEKARMTFLLDSAGTEDKPLKIPKEVWLLVNHLYTKAC 810

  Fly   680 KQVGAFPSYDSRLSLGAQFNSVRDWLDTWSDDPFPANAETAAQALLLLLD-LPEHALLEPVVENL 743
            :|...|.:    ..|..:..|:.|.|||...|..|....:.|:|||:.|: |||..|...:.:..
Zfish   811 QQEDLFQT----PGLQDELQSIIDCLDTSIPDSIPGCNHSVAEALLIFLEALPEPVLCYELFQRC 871

  Fly   744 LECTNKSQ-AMDYISLLSPPKRNVFMHLCMFLRAGIESQF---YDLHQVASTFGRILLR 798
            |||::.|: ....||.|....||||.:|..|||..::...   .:.:.:|:.|..:|:|
Zfish   872 LECSHDSRLCKQLISQLPRAHRNVFRYLMAFLRELLKHSIDNNLNANLLATLFASLLIR 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ocrl	NP_001259153.1	PH-like	23..163	CDD:302622	21/153 (14%)
		INPP5c_INPP5B	185..478	CDD:197327	120/298 (40%)
		RhoGAP_OCRL1	614..823	CDD:239845	67/207 (32%)
ocrl	XP_009289414.1	PH_OCRL1	13..122	CDD:270182
		INPP5c_INPP5B	302..593	CDD:197327	120/298 (40%)
		RhoGAP_OCRL1	728..956	CDD:239845	67/207 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2506
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H233
Inparanoid	1	1.050	436	1.000	Inparanoid score	I1656
OMA	1	1.010	-	-		QHG54104
OrthoDB	1	1.010	-	-		D129921at33208
OrthoFinder	1	1.000	-	-		FOG0002633
OrthoInspector	1	1.000	-	-		otm25123
orthoMCL	1	0.900	-	-		OOG6_101357
Panther	1	1.100	-	-	LDO	PTHR11200
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X494
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.840